Division of Experimental Allergy and Immunodermatology
Division of Experimental Allergy and Immunodermatology
The Division of Experimental Allergy and Immunodermatology has several research laboratories covering more than 130 square meters on the Wechloy campus, which were completed in 2017. Our research focus is on autoimmune diseases such as bullous pemphigoid, allergies, cancer and inflammatory skin conditions such as atopic dermatitis, contact dermatitis and psoriasis.
We are particularly interested in the role of basophil and eosinophilic granulocytes and mast cells in these diseases, whose released inflammatory mediators play a crucial role in the severity of the symptoms of these diseases and also affect other immune cells that control these diseases. Our research is funded, inter alia, by the DFG. Methodologically, we cover the entire spectrum of cellular inflammatory research with target cell isolation, cell culture, Western blotting, PCR, immunohistochemistry, histamine release assays, ELISA, cytation imaging, and FACS.
Our teaching focuses on the entire spectrum of dermatology and allergy, the basics of immunology and biochemistry.
Univ-Prof. Dr. Ulrike Raap
Department of Dermatology and Allergy
Department of Experimental Allergy and Immunodermatology
The focus of our research group is on autoimmune diseases, such as bullous pemphigoid, allergies, cancer and inflammatory skin diseases including atopic dermatitis, contact eczema and psoriasis. We are particularly interested in the role of basophils, eosinophils and mast cells in these diseases since the inflammatory mediators released from these cells play a crucial role in the severity of symptoms and also impact on other immune cells that govern these diseases. Our group has many years of experience in isolating and purifying human allergic effector cells in order to study their functional responses and shed light on the intracellular signaling mechanisms that control their reactivity. Our main goal is to understand the different roles these cells play in autoimmunity and allergies and in developing new therapeutic strategies.
Ongoing international research collaborations include the University of Groningen (NL), where we are researching the causes of skin blistering in bullous pemphigoid, Imperial College London (UK) and the University Clinic of Pulmonary and Allergic Diseases Golnik (SLO), where we are investigating the cellular causes for severe allergic reactions, and the University of Kent, where we are studying fundamental mechanisms responsible for autoimmune diseases and cancer.
Duderstadt S, Raap U, Patsinakidis N (2021) Rapid therapeutic response of palmoplantar pustulosis under biologic treatment with guselkumab. Dermatol Ther. 2021 Jan 21;e14792. doi: 10.1111/dth.14792. Online ahead of print.
Kleiner S, Rüdrich U, Gehring M, Loser K, Eiz-Vesper B, Noubissi Nzeteu G, Patsinakidis N, Meyer NH, Gibbs BF, Raap U (2021) Human basophils release the anti-inflammatory cytokine IL-10 following stimulation with α-melanocyte-stimulating hormone. J Allergy Clin Immunol. 2021 Jan 15;S0091-6749(21)00009-9.doi: 10.1016/j.jaci.2020.12.645. Online ahead of print.
Yasinska IM, Meyer NH, Schlichtner S, Hussain R, Siligardi G, Casely-Hayford M, Fiedler W, Wellbrock J, Desmet C, Calzolai L, Varani L, Berger SM, Raap U, Gibbs BF, Fasler-Kann E, Sumbayev VV. (2020) Ligand-Receptor Interactions of Galectin-9 and VISTA Suppress Human T Lymphocyte Cytotoxic Activity. Front. Immunol., 20 November 2020 | doi.org/10.3389/fimmu.2020.580557.
Patsinakidis N, Meyer NH, Raap U. (2020) [Psoriasis] MMW Fortschr Med. Nov;162(Suppl 3):43-50. doi: 10.1007/s15006-020-1458-8.
Lamberts A, Kotnik N, Diercks GFH, Meijer JM, Di Zenzo G, Pas HH, Jonkman MF, Gibbs BF, Raap U, Horváth B. (2020) IgE autoantibodies in serum and skin of nonbullous and bullous pemphigoid patients. J Eur Acad Dermatol Venereol 2020 Oct 15. doi: 10.1111/jdv.16996. Online ahead of print.
Köthe A, Patsinakidis N, Raap U. Fixes bullöses Arzneimittelexanthem. Akt Dermatol 2020; 46:344-350.
Kotnik N, El-Sourani N, Raap U, Raab HR, Bockhorn M, Meyer H, Troja A. (2020) Expression of MicroRNA in Locoregional Recurrent Rectal Cancer. Anticancer Res. 2020 May;40(5):2947-2953. doi: 10.21873/anticanres.14273.PMID: 32366447
Guseva D, Rüdrich U, Kotnik N, Gehring M, Patsinakidis N, Agelopoulos K, Ständer S, Homey B, Kapp A, Gibbs BF, Ponimaskin E, Raap U (2020). Neuronal branching of sensory neurons is associated with BDNF-positive eosinophils in atopic dermatitis. Clin Exp Allergy. 2020 Jan 10. doi: 10.1111/cea.13560. [Epub ahead of print]
Papakonstantinou E, Raap U (2020). Herpes Zoster Schwere Komplikationen verhindern. Der Deutsche Dermatologe 2020; 68 (2): 114-122.
Schnuch A, Schubert S, Lessmann H, Geier J; IVDK. (2020). The methylisothiazolinone epidemic goes along with changing patients' characteristics - After cosmetics, industrial applications are the focus. Contact Dermatitis. 2020 Feb;82(2):87-93. doi: 10.1111/cod.13414. Epub 2019 Nov 17.
Meyer NH, Dellago H, Tam-Amersdorfer C, Merle DA, Parlato R, Gesslbauer B, Almer J, Gschwandtner M, Leon A, Franzmann TM, Grillari J, Kungl AJ, Zangger K, Falsone SF (2019) Structural Fuzziness of the RNA-Organizing Protein SERF Determines a Toxic Gain-of-interaction. J Mol Biol. 2019 Nov 30. pii: S0022-2836(19)30679-5. doi: 10.1016/j.jmb.2019.11.014. [Epub ahead of print].
Dermatology - Prof. Dr. med. Ulrike Raap
Immunodermatology and Allergy - Prof. Dr. med. Ulrike Raap
Foundations of Immunology - Prof. Dr. rer. nat. Bernhard Gibbs
Problem-based learning - Prof. Dr. rer. nat. Bernhard Gibbs
Biochemistry - Dr. rer. nat. Helge Meyer
Dermatology - Dr. med. Occo Kautz