by Julia Witt


Nanotoxicity is a new scientific discipline [1, 2] which requires the development of appropriate tools for the determination of nano-objects such as metallic nanoparticles (NPs). These tools should provide information about the possible interaction between nano-objects and biological systems. The main aspect of this project concerns the development of so called NIP (Nanoparticle Imprinted Polymer) concept for the selective recognition of NPs by a polymeric matrix. NPs will be used as templates to imprint organic matrices on solid supports. After releasing the NP by oxidative dissolution, the material shall be selective for a reuptake of NP with the same size and surface functionality. The imprinted matrices can be used as sensor materials for the speciation of NPs conceptionally similar to the already existing molecular-imprinted polymers (MIPs) [3, 4]. Such measurement tools have a growing importance as toxicity of NPs depends on size, surface functionality and elements/compounds forming the core [5, 6]. Recently, we published a new concept based on nanoparticle-imprinted polymers (NIPs) combined with electrochemical detection of NPs. [7] The new sensor principle was illustrated by a polyaniline film transferred simultaneously with template AuNPs by the Langmuir-Blodgett technique. After electro-oxidation of the Au NPs, open cavities were detected in the film able to re-capture analyte NPs with size-exclusion behavior. [7] Currently extended our route for NIP concept to other matrix and NP systems and follow new routes for NIP formation.

Used techniques: LB, XPS, voltammetry, SEM, SFM

[1]Colvin, V. L. Nat. Biotechnol. 200321, 1166-1170.
[2]Nel, A.; Xia, T.; Mädler, L.; Li, N. Science 2006311, 622-627.
[3]Haupt, K. Analyst 2001126, 747-756.
[4]Piletsky, S. A.; Turner, A. P. F. Electroanalysis 200214, 317-323.
[5]Leroueil, P. R.; Hong, S.; Mecke, A.; Baker, J. R.; Orr, B. G.; Banaszak Holl, M. M. Acc. Chem. Res. 200740, 335-342.
[6]Bantz, C.; Koshkina, O.; Lang, T.; Galla, H.-J.; Kirkpatrick, C. J.; Stauber, R. H.; Maskos, M. Beilstein J. Nanotechnol. 20145, 1774-1788.
[7]Kraus-Ophir, S.; Witt, J.; Wittstock, G.; Mandler, D. Angew. Chem. Int. Ed. 201453, 294-298.
(Changed: 2021-04-30)