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The Neurogenetics group (Prof. Nothwang) at the School of Medicine and Health Sciences, University of Oldenburg, offers a

PhD position
(TV-L E13, 65%)

in Developmental Evolutionary Neurobiology. The position is funded for three years.

Deafness is the most common sensory disorder in human affecting 1 in 1000 newborns. Most of these cases can be referred to genetic causes. Analyses in mice showed that mutations in deafness-related genes often result in morphological and functional abnormalities not only in the inner ear but also in the central auditory system (Satheesh et al., 2012; Willaredt et al., 2014).
Recent studies of our group identified components of the gene regulatory network to be essential for proper development and function of the auditory hindbrain (Schlueter et al., 2018; Ebbers et al., 2016). However, a comprehensive analysis of the genetic program underlying its formation is currently missing. To this end, we seek to apply state-of-the-art techniques such as single cell transcriptome analysis of fluorescent labeled cells to determine the gene regulatory network underlying the development of excitatory auditory neurons in the hindbrain. These neurons play a crucial role in sound localization.

Task profile:

  • Isolation of fluorescent-labeled cells from brain tissue
  • RNA-isolation for RNAseq analysis and RT-qPCR
  • Bioinformatic analysis of RNAseq data
  • Immunohistological analysis, RNA in situ hybridization
  • Mouse breeding and genotyping

We seek a highly motivated PhD student with:

  • Academic university degree (Master or Diploma) in biology or related fields
  • Hands-on experiences in cellular neurobiology or genetics (RNA isolation, PCR, immunohistochemistry)
  • Experience in statistical analysis and microscopy
  • Basic knowledge of gene regulatory networks or bioinformatics (Linux environment, R) are of advantage
  • Experience with single cell isolation (FACS, patch-clamp, Laser microdissection) are of advantage
  • Ability to work independently, thoroughly and as a team player in a young and dynamic group

We offer an attractive work environment with excellent facilities (STED and confocal microscopy, Axioscan microscope, patch-clamp set-up, real time PCR, animal facility), and training. The project is embedded into several national and international collaborations with the possibility of a research stay abroad.

The Carl von Ossietzky University of Oldenburg is an equal opportunity employer aiming to increase the proportion of female academic staff members. Therefore, we especially encourage women to apply. Applicants with disabilities will be given preference if equally qualified.

Please submit your motivation letter, CV, certificates and name of two references (by E-Mail as a single PDF-file) until 31st January 2019 to:

Dr. Lena Ebbers
Abt. Neurogenetik
Carl von Ossietzky Universität Oldenburg
Carl von Ossietzky Str. 9-11
D-26129 Oldenburg

Chr9lqvisti5ksna Osw0faldu5o (ch2sxgristina.oswvykppald@uweolnex.devk) (Stand: 22.01.2019)