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Gap junctions as mediators of health signals in the diseased retina

The Neurosensorics Group at the Carl von Ossietzky University of Oldenburg invites applications for

a PhD student position (m,f,d) (65% E13 TV-L, 3 years).

This position is available immediately and is part of the ERA-Net Neuron grant (https://www.neuron-eranet.eu/_media/Rethealthsi.pdf). You will be supervised by apl. Prof. Dr. Karin Dedek (https://uol.de/karin-dedek/).

The selected candidate will apply single cell dye injections, immunohistochemistry and recordings to study gap junctions in cell culture and mouse models for photoreceptor degeneration. The aim of the project is to study how intracellular messengers, epigenetic factors and pharmacologically active substances spread through gap junctions to assess their therapeutic potential for retina degeneration diseases. The project is carried in collaboration with Prof. Bela Völgyi (University of Pecs, Hungary), Prof. Stanislao Rizzo (Policlinico Universitario Agostino Gemelli IRCCS, Italy), and Prof. Enrica Strettoi (CNR, Pisa, Italy).

About the Dedek lab:

Our research focuses on the neural processing of signals in the retina of mice and birds. We have made significant contributions to gap junctional networks in the mouse retina (1,2) and the functional role of horizontal cells (3,4). Ongoing work includes gap junctions in the mouse retina, and retinal circuitry and magnetoreception in birds.

Profile:

We seek for a highly motivated individual with strong quantitative and technical skills and great team spirit to work in an international environment.

Requirements:

  • diploma or master’s (M.Sc.) degree in neuroscience, biology or a related discipline
  • experience in single-electrode electrophysiology is highly desirable
  • experience in cell culture, cellular imaging, confocal microscopy or/and quantitative immunohistochemistry is advantageous
  • good command of the English language (written and spoken) is a must.

We offer:

  • Opportunity to do cutting edge science in a supportive and collaborative team.
  • State-of-the-art tools and facilities: The laboratory is equipped with a patch-clamp rig and has access to a modern microscopy facility (confocal, STED microscopy).
  • Enrolment in the local graduate school with a large offer of soft and scientific skills courses, providing ample possibilities for career development.

The University of Oldenburg is aware of the power of diversity. In order to increase the percentage of female faculty and staff members, female candidates with equal qualification will be given preference. Applicants with disabilities will be preferentially considered in case of equal qualification.

How to apply:

The application consists of a CV, a short statement of research motivation and experience (max. 2 pages), and the names and phone numbers of at least two references. Please compile your application in one single PDF-file and email it to .

Submissions will only be accepted if they are received no later than May 18, 2021. We will start looking at the applications as soon as they are submitted and will consider further applications until the positions are filled.

References:

1. Tetenborg et al. (2020) Sci Rep 10(1):18378. 3. Ströh S et al. (2018) J Neurosci 38(8):2015-2028.

2. Meyer A et al. (2014) J Cell Sci 127:1190-1202. 4. Sonntag S et al. (2012) J Neurosci 32(31):10713-24 

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(Stand: 30.04.2021)