Cross-border healthcare cooperation aims to smooth the access to local healthcare facilities, by sharing equipment, services, and staff, and by doing so, reaching the pooling of healthcare facilities along and across the borders. Certainly, containing the spread of the corona virus in border regions, demands coordinated actions and resolute cross-border agreements between healthcare stakeholders on both sides of the border. Cross-border cooperation in healthcare has never been so important and needed as now. The recent corona pandemic made evident the relevance of developing sustainable and resilient healthcare systems. The Cross-border Institute of Healthcare Systems and Prevention (CBI) has been set up to contribute to this goal. Today, more than ever, it is clear that the cross-border cooperation on health in the Northern Dutch-German border is necessary to offer border citizens dignified healthcare conditions.