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Oldenburg

Nina Löchte, M.A.

Tel.: +49 441 798-3040

nina.loosechtsfe@uoyihl.dedmg

Groningen

Dr. Desiree Jansen

Tel.: + 31 50 361 6780

d.f.jadyumnsen@umv9pmcg.s6ufnlu0sz

Project 3: Ciliopathies and intracellular signaling – unravelling the underlying mechanisms and implications for therapeutic approaches

Prof. Dr. John Neidhardt
Faculty of Medicine and Health Sciences
Dept. of Human Medicine
Human Genetics
Carl von Ossietzky University Oldenburg

Prof. Dr. Kathrin Thedieck
Lab for Metabolic Signaling
European Medical School Oldenburg-Groningen
Lab of Pediatrics
University Medical Center Groningen (UMCG)

N.N.
PhD Student

Summary: Ciliopathies are human genetic diseases caused by mutations in genes coding for functional or structural components of the cilium. Cilia exist on virtually every cell of the human body. Consequently, genetic disturbance of ciliary functions has severe consequences, frequently leading to syndromic phenotypes including retinal dystrophy, renal dysfunction, cognitive delay, and metabolic diseases. Currently, no targeted or pathogenic mechanism-based therapy exists. Dysregulated intracellular signaling is recognized to drive many diseases, and has been linked with ciliary function. In this project, we will use patient-derived cell lines and will (1) comparatively analyze dysregulated signaling in different ciliopathies, (2) explore known and discover novel links between cilia and intracellular signaling, and (3) develop drug interventions targeting the underlying molecular mechanisms. As compounds targeting cellular signaling are in the clinics since many years, our results may open new, mechanism-based treatment avenues to patients suffering from ciliary diseases.

 

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