Prof. Dr. Christiane Richter-Landsberg




Short-term incubation of gabapentin or pregabalin does not affect chemically induced injury in neuronal cell models in vitro.
Baldewig M, Goldbaum O, Richter-Landsberg C, Weyland A, Bantel C.
J Pain Res. 2018 Jun 20;11:1181-1190. doi: 10.2147/JPR.S162322. eCollection 2018. PMID: 29950890


HDAC6 inhibition by tubastatin A is protective against oxidative stress in a photoreceptor cell line and restores visual function in a zebrafish model of inherited blindness.
Leyk J, Daly C, Janssen-Bienhold U, Kennedy BN, Richter-Landsberg C.
Cell Death Dis. 2017 Aug 31;8(8):e3028. doi: 10.1038/cddis.2017.415. PMID: 29048427

Higher levels of myelin phospholipids in brains of neuronal α-Synuclein transgenic mice precede myelin loss.
Grigoletto J, Pukaß K, Gamliel A, Davidi D, Katz-Brull R, Richter-Landsberg C, Sharon R.
Acta Neuropathol Commun. 2017 May 8;5(1):37. doi: 10.1186/s40478-017-0439-3. PMID: 28482862

2015 / 2016

Dimethylsulfoniopropionate Promotes Process Outgrowth in Neural Cells and Exerts Protective Effects against Tropodithietic Acid.

Wichmann H, Brinkhoff T, Simon M, Richter-Landsberg C. Mar Drugs. 2016 May 6;14(5). pii: E89. doi: 10.3390/md14050089.

International Meeting Molecular Neurodegeneration: News and Views in Molecular Neuroscience in Health and Disease. Delmenhorst, Germany, July 20-22, 2015.

Gozes I, Baas PW, Richter-Landsberg C. J Mol Neurosci. 2015 Oct;57(2):153-9. doi: 10.1007/s12031-015-0637-z.

Cytotoxic Effects of Tropodithietic Acid on Mammalian Clonal Cell Lines of Neuronal and Glial Origin.

Wichmann H, Vocke F, Brinkhoff T, Simon M, Richter-Landsberg C. Mar Drugs. 2015 Nov 27;13(12):7113-23. doi: 10.3390/md13127058.

ADNP/ADNP2 expression in oligodendrocytes: implication for myelin-related neurodevelopment

Malishkevich A, Leyk J, Goldbaum O, Richter-Landsberg C, Gozes I. J Mol Neurosci. 2015 Aug 28. [Epub ahead of print]

Mitochondrial impairment and oxidative stress compromise autophagosomal degradation of alpha-synuclein in oligodendroglial cells

Pukaß K, Goldbaum O, Richter-Landsberg C. J Neurochem. 2015 Jul 24. doi: 10.1111/jnc.13256.[Epub ahead of print]

Protein Aggregate Formation in Oligodendrocytes: Tau and the Cytoskeleton at the intersection of neuroprotection and Neurodegeneration

Richter-Landsberg C. Biol Chem. 2015 Jun 17. doi: 10.1515/hsz-2015-0157.[Epub ahead of print]

Inhibition of UCH-L1 in oligodendroGlial cells results in microtubule stabilization and prevents alpha-synuclein aggregate formation by activating the autophagic pathway: implications for multiple system athrophy

Pukaß K and Richter-Landsberg C. Front Cell Neurosci. 2015 May 5. doi: 10.3389/fncel.2015.00163

Downregulation of the microtubule associated protein Tau impairs process outgrowth and myelin basic protein mRNA transport in oligodendrocytes.

Seiberlich V, Bauer NG, Schwarz L, Ffrench-Constant C, Goldbaum O, Richter-Landsberg C. Glia. 2015 Apr 4. doi:10.1002/glia.22832.[Epub ahead of print]

Inhibition of HDAC6 Modifies Tau Inclusion Body Formation and Impairs Autophagic Clearance

Leyk J, Goldbaum O, Noack M, Richter-Landsberg C. J Mol Neurosci. 2015; 55(4):1031-1046

Activation of Autophagy by Rapamycin Does Not Protect Oligodendrocytes Against Protein Aggregate Formation and Cell Death Induced by Proteasomal Inhibition

Noack M, Richter-Landsberg C. J Mol Neurosci. 2015; 55(1):99-108


HDAC6 Inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes

Noack M, Leyk J, Richter-Landsberg C. Glia. 2014; 62(4):535-547

Oxidative Stress promotes uptake, accumulation, and oligomerization of extracellular alpha-Synuclein in oligodendrocytes

Pukaß K, Richter-Landsberg.  J Mol Neurosci. 2014; 52(3):339-352


Inclusion body formation, macroautophagy, and the role of HDAC6 in neurodegeneration

Richter-Landsberg C, Leyk J. Acta Neuropathol. 2013; 126(6):793-807


Inhibition of protein deubiquitination by pr-619 activates the autophagic pathway in oln-t40 oligodendroglial cells

Seiberlich V, Borchert J, Zhukareva V, Richter-Landsberg C. Cell Biochem Biophys. 2013; 67(1):149-160


FAS-Dependent cell death in alpha-Synuclein transgenic Oligodendrocyte models of multiple system athrophy

Kragh CL, Fillon G, Gysbers A, Hansen HD, Neumann M, Richter-Landsberg C, Haass C, Zalc B, Lubetzki C, Gai WP, Halliday GM, Kahle PJ, Jensen PH. PLoS One. 2013;8(1):e55243. doi: 10.1371/journal.pone.0055243. Epub 2013 Jan 25.


SUMO-1 is associated with a subset of lysosomes in glial protein Aggregate diseases

Wong MB, Goodwin J, Norazit A, Meedeniya AC, Richter-Landsberg C, Gai WP, Pountney DL. Neurotox Res. 2013 Jan;23(1):1-21. doi: 10.1007/s12640-012-9358-z. Epub 2012 Nov 15.


Increased Neuronal alpha-Synuclein Pathology Associates with Its Accumulation in Oligodendrocytes in Mice Modeling alpha-Synucleinopathies

Kisos H, Pukaß K, Ben-Hur T, Richter-Landsberg C, Sharon R. PLoS One. 2012; 7(10): e46817
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The small molecule inhibitor PR-619 of deubiquitinating enzymes affects the microtubule network and causes protein aggregate formation in neural cells: Implications for neurodegenerative diseases.

Seiberlich V, Goldbaum O, Zhukareva V, Richter-Landsberg C. Biochim Biophys Acta. 2012; 1823(11):2057-2068

Involvement of Macroautophagy in Multiple System Atrophy and Protein Aggregate Formation in Oligodendrocytes.

Schwarz L, Goldbaum O, Bergmann M, Probst-Cousin S, Richter-Landsberg C. J Mol Neurosci. 2012; 47(2):256-266


Membrane Lipid Modification by Docosahexaenoic Acid (DHA) Promotes the Formation of alpha-Synuclein Inclusion Bodies Immunopositive for SUMO-1 in Oligodendroglial Cells After Oxidative Stress.

Riedel M, Goldbaum O, Wille M, Richter-Landsberg C. J Mol Neurosci. 2011 43(3):290-302


Autophagy is activated by proteasomal inhibition and involved in aggresome clearance in cultured astrocytes.

Jänen SB, Chaachouay H, Richter-Landsberg C. Glia. 2010 1;58(14):1766-1774.

17-AAG induces cytoplasmic alpha-synuclein aggregate clearance by induction of autophagy. 

Riedel M, Goldbaum O, Schwarz L, Schmitt S, Richter-Landsberg C. PLoS One. 2010; 5(1):e8753. PMID: 20090920
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Membrane lipid modification by polyunsaturated fatty acids sensitizes oligodendroglial OLN-93 cells against oxidative stress and promotes up-regulation of heme oxygenase-1 (HSP32). 

Brand A, Bauer NG, Hallott A, Goldbaum O, Ghebremeskel K, Reifen R, Richter-Landsberg C. J Neurochem. 2010; 113(2):465-476.

The Small Heat Shock Protein HSP25/27 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration. 

Schwarz L, Vollmer G, Richter-Landsberg C. Int J Cell Biol. 2010; 2010:717520.

Role of the oligodendroglial cytoskeleton in differentiation and myelination.

Bauer NG, Richter-Landsberg C, Ffrench-Constant C; Glia. 2009 Dec; 57(16):1691-705

The small heat shock protein HSP25 protects astrocytes against stress induced by proteasomal inhibition.

Goldbaum O,Riedel M, Stahnke T, Richter-Landsberg C; Glia. 2009 Nov 1;57(14):1566-77

alpha-Synuclein Promotes the Recruitment of Tau to Protein Inclusions in Oligodendroglial Cells: Effects of Oxidative and Proteolytic Stress.

Riedel M, Goldbaum O, Richter-Landsberg C; J Mol Neurosci. 2009 Sep;39(1-2):226-34

The expression of tubulin polymerization promoting protein TPPP/p25alpha is developmentally regulated in cultured rat brain oligodendrocytes and affected by proteolytic stress.

Goldbaum O, Jensen PH, Richter-Landsberg C;  Glia 2008 Dezember, 56 (16): 1736-46.

The Cytoskeleton in Oligodendrocytes: Microtubule Dynamics in Health and Disease.

Richter-Landsberg C; J Mol Neurosci. 2008 May; 35(1): 55-63


The dynamic instability of microtubules is required for aggresome formation in oligodendroglial cells after proteolytic stress.
Bauer NG, Richter-Landsberg C; J Mol Neurosci 2006, 29(2):153-168.

Proteasome inhibition by MG-132 induces apoptotic cell death and mitochondrial dysfunction in cultured rat brain oligodendrocytes but not in astrocytes.
Goldbaum O, Vollmer G, Richter-Landsberg C; Glia 2006 June, 53:891-901.

Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies.
Uryu K, Richter-Landsberg C, Welch W, Sun E, Goldbaum O, Norris EH, Pham CT, Yazawa I, Hilburger K, Micsenyi M, Giasson BI, Bonini NM, Lee VM, Trojanowski JQ; Am J Pathol. 2006 Mar;168: 947-61.


Tau-Inclusion Body Formation in Oligodendroglia: the Role of Stress Proteins and Proteasome Inhibition

Richter-Landsberg C and Bauer NG; Int. J. Dev. Neurosci. 2004 Nov, 22(7)443-51

Proteolytic stress causes heat shock protein induction, tau ubiquitination, and the recruitment of ubiquitin to tau-positive aggregates in oligodendrocytes in culture

Goldbaum O and Richter-Landsberg C; J. Neurosci. 2004 June 23, 24(25):5748-5757.

Mitochondrial pathway is involved in hydrogen-peroxide-induced apoptotic cell death of oligodendrocytes

Mronga T, Stahnke T, Goldbaum O, Richter-Landsberg C; Glia 2004 May; 46(4):446-55.

Triethyltin-induced stress responses and apoptotic cell death in cultured oligodendrocytes.

Stahnke T, Richter-Landsberg C; Glia 2004 May; 46(3):334-44.

Proteasome inhibition stabilizes tau inclusions in oligodendroglial cells that occur after treatment with okadaic acid.

Goldbaum O, Oppermann M, Handschuh M, Dabir D, Zhang B, Forman MS, Trojanowski JQ, Lee VM, Richter-Landsberg C; J Neurosci. 2003 Oct 1;23(26):8872-80.

Stress proteins in neural cells: functional roles in health and disease.

Richter-Landsberg C, Goldbaum O; Cell Mol Life Science 2003 Feb;60(2):337-49. Review.

Activation of PP2A-like phosphatase and modulation of tau phosphorylation accompany stress-induced apoptosis in cultured oligodendrocytes.

Goldbaum O, Richter-Landsberg C; Glia 2002 Dec;40(3):271-82

Stress proteins in oligodendrocytes: differential effects of heat shock and oxidative stress.

Goldbaum O, Richter-Landsberg C; J Neurochem. 2001 Sep;78(6):1233-42.

Developmental changes of tau protein and mRNA in cultured rat brain oligodendrocytes.

Gorath M, Stahnke T, Mronga T, Goldbaum O, Richter-Landsberg C; Glia. 2001 Oct;36(1):89-101.

Organization and functional roles of the cytoskeleton in oligodendrocytes.

Richter-Landsberg C; Microsc Res Tech. 2001 Mar 15;52(6):628-36. Review.

alpha-Synuclein is developmentally expressed in cultured rat brain oligodendrocytes.

Richter-Landsberg C, Gorath M, Trojanowski JQ, Lee VM; J Neurosci Res. 2000 Oct 1;62(1):9-14. 

Glial cells as targets and producers of neurotrophins.

Althaus HH, Richter-Landsberg C; Int Rev Cytol. 2000;197:203-77. Review.

The oligodendroglia cytoskeleton in health and disease.

Richter-Landsberg C; J Neurosci Res. 2000 Jan 1;59(1):11-8. Review.

(Changed: 19 Jan 2024)  | 
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