Prof. Dr. Karl-Wilhelm Koch
Tel.: +49-(0)441-798-3640
Office: W4 1-137

2000 - 2005

Publications 2000

Koch, K.-W. (2000) Identification and Characterization of Calmodulin Binding Sites in the cGMP-Gated Channel Using Surface Plasmon Resonance Spectroscopy. Meth. Enzymol. 315, 785-797

Kappler, J., Franken, S., Junghans, U., Hoffmann, R., Linke, T., Müller, H. W. and Koch, K.-W. (2000) Glycosaminoglycan-binding properties and secondary structure of the C-terminus of netrin-1. Biochem. Biophys. Res. Commun. 271, 287-291

Duda, T., Venkataraman, V., Jankowska, A., Lange, C., Koch, K.-W. and Sharma, R. K. (2000) Impairmment of the Rod Outer Segment Membrane Guanylate Cyclase Dimerization in a Cone-Rod Dystrophy Results in Defective Calcium Signaling. Biochemistry 39, 12522-12533

Publications 2001

Müller, F.,Vantler, M., Weitz, D., Eismann, E., Zoche, M., Koch, K.-W. and Kaupp, U.B. (2001) Ligand sensitivity of the a2 subunit from bovine cone cGMP-gated channel is modulated by PKC but not by calmodulin J. Physiol. 532, 399-409

Fischer, T., Beyermann, M. and Koch, K.-W. (2001) Application of different  Surface Plasmon Resonance  biosensor chips to monitor the interaction of the CaM-binding site of nitric oxide synthase I and calmodulin Biochem. Biophys. Res. Commun. 285, 463-469

Hwang, J.-Y., Schlesinger, R. and Koch, K.-W. (2001) Calcium-dependent cystein reactivities in the neuronal calcium sensor guanylate cyclase-activating protein 1. FEBS Lett. 508, 355-359

Publications 2002

Duda, T., Koch, K.-W., Venkataraman, V., Lange, C., Beyermann, M. and Sharma, R. K. (2002) Ca2+-sensor S100b modulated sites of membrane guanylate cyclase in the photoreceptor-bipolar synapse. EMBO J. 21, 2547-2556 (Duda and Koch, joint first authorship)

Censarek, P., Beyermann, M. and Koch, K.-W. (2002) Target recognition of apocalmodulin by nitric oxide synthase I peptides. Biochemistry 41, 8598-8604

Hwang, J.-Y. and Koch, K.-W. (2002) Calcium- and myristoyl-dependent properties of guanylate cyclase-activating protein-1 and –2. Biochemistry 41, 13021-13028

Hwang, J.-Y. and Koch, K.-W. (2002) The myristoylation of the neuronal Ca2+-sensors guanylate cyclase-activating protein 1 and 2. Biochim. Biophys. Acta 1600, 111-117

Fischer, T., Senin, I., Philippov, P.P. and Koch, K.-W. (2002) Application of different lipid surfaces to monitor protein-membrane interactions by surface plasmon resonance spectroscopy. Spectroscopy- An International Journal- 16, 271-279

Senin, I. I., Fischer, T., Komolov, K. E., Zinchenko, D. V., Philippov, P. P. and Koch, K.-W. (2002) Ca2+-myristoyl switch in the neuronal calcium sensor recoverin requires different functions of Ca2+-binding sites. J. Biol. Chem. 277, 50365-50372

Duda, T. and Koch, K.-W. (2002) Retinal Diseases Linked with Photoreceptor Guanylate Cyclase. Mol. Cell. Biochem. 230, 129-138

Koch, K.-W., Duda, T. and Sharma, R.K. (2002) Photoreceptor Specific Guanylate Cyclases in Vertebrate Phototransduction. Mol. Cell. Biochem. 230, 97-106

Duda, T. and Koch, K.-W. (2002) Calcium-modulated membrane guanylate cyclase in synaptic transmission? Mol. Cell. Biochem. 230, 107-116

Senin, I.I., Koch, K.-W., Akhtar, M. and Philippov, P.P. (2002) Ca2+-dependent control of rhodopsin phosphorylation: recoverin and rhodopsin kinase. Adv. Exp. Med. Biol. 514, 69-99

Koch, K.-W. (2002) Target recognition of guanylate cyclase by guanylate cyclase-activating proteins. Adv. Exp. Med. Biol. 514, 349-360

Publications 2003

Nguyen-Duong, M., Koch, K.-W. and Merkel, R. (2003) Surface anchoring reduces the lifetime of single specific bonds. Europhysics Letters 61, 845-851

Venkataraman, V., Duda, T., Vardi, N., Koch, K.-W. and Sharma, R.K. (2003) Calcium-modulated guanylate cyclase (ROS-GC1) transduction machinery in the photoreceptor-bipolar region. Biochemistry  42, 5640-5648

Weiergräber, O.H., Senin, I.I., Philippov, P.P., Granzin, J. and Koch, K.-W. (2003) Impact of N-terminal myristoylation on the Ca2+-dependent conformational transition in recoverin. J. Biol. Chem. 278, 22972-22979

Senin, I.I. Vaganova, S.A. Weiergräber, O.H., Ergonov, N. S., Philippov, P.P. and Koch, K.-W. (2003) Functional restoration of the Ca2+-myristoyl switch in a recoverin mutant. J. Mol. Biol. 330, 409-418

Hwang, J.-Y., Lange, C., Helten, A., Höppner-Heitmann, D., Duda, T., Sharma, R.K. and Koch, K.-W. (2003) Regulatory modes of rod outer segment membrane guanylate cyclase differ in catalytic efficiency and Ca2+-sensitivity. Eur. J. Biochem. 270, 3814-3821

Publications 2004

Hwang, J.-Y., Schlesinger, R. and Koch, K.-W. (2004) Irregular dimerization of guanylate cyclase-activating protein 1 mutants causes loss of target activation. Eur. J. Biochem. 271, 3785-3793

Senin, I.I., Hoeppner-Heitmann, D., Polkovnikova, O.O., Churumova, V.A., Tikhomirova, N.K., Philippov, P.P. and Koch, K.-W. (2004) Recoverin and rhodopsin kinase activity in detergent-resistant membrane rafts from rod outer segments. J. Biol. Chem. 279, 48647-48653

Censarek, P. Beyermann, M. and Koch, K.-W. (2004) Thermodynamics of apocalmodulin and nitric oxide synthase II peptide interaction. FEBS Lett. 577, 465-468

Sharma, R. K., Duda, T. Venkataraman, V., Koch, K.-W. (2004) Calcium-modulated Mammalian Membrane Guanylate Cyclase ROS-GC Transduction Machinery in Sensory Neurons: A Universal Concept. Current Topics in Biochemical Research Vol.6, 111-144

Publications 2005

Komolov, K. E., Zinchenko, D. V., Churumova, V. A.,  Vaganova, S. A., Weiergräber, O. H., Senin, I. I.,Philippov, P. P and Koch, K.-W. (2005) One of the Ca2+ binding sites in recoverin exclusively controls interaction with rhodopsin kinase. Biol. Chem. 386, 285-289

Duda, T., Fik-Rymarkiewicz, E., Venkataraman, V., Krishnan, R., Koch, K.-W. and Sharma, R. K. (2005) The Calcium-sensor Guanylate Cyclase Activating Protein type 2 -specific site in Rod Outer Segment Membrane Guanylate Cyclase type 1. Biochemistry 44, 7336-7345

Weiergräber, O.H. und Koch, K.-W. (2005) Myristyl-Schalter in der neuronalen Signaltransduktion. Biospektrum 2/2005; 174-175

(Changed: 19 Jan 2024)  | 
Zum Seitananfang scrollen Scroll to the top of the page