Prof. Dr. Karl-Wilhelm Koch
Tel.: +49-(0)441-798-3640
Office: W4 1-137

2006 - 2010

Publikationen 2006

Komolov  K. E., Senin, I.,  Philippov, P.P. and Koch, K.-W. (2006) Surface Plasmon Resonance study of G protein/receptor coupling in a lipid bilayer-free system. Anal. Chem. 78, 1228-1234

Weiergräber O., Senin, I.I., Zernii, E. Y., Churumova, V.A., Kovaleva, N.A., Nazipova, A. A., Permyakov, S.E., Permyakov, E.A., Philippov, P.P., Granzin, J., and Koch, K.-W. (2006) Tuning of a neuronal calcium sensor. J. Biol.Chem. 281, 37594-37602

Koch, K.-W. (2006) GCAPs, the classical neuronal calcium sensors in the retina – a Ca2+-relay model of guanylate cyclase activation. Calcium Binding Proteins 1, 3-6

Koch, K.-W. (2006) Surface Plasmon Resonance. Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine (D.Ganten & K.Ruckpaul Ed. Springer), 1832-1835

Philippov, P.P., Senin, I.I. and Koch, K.-W. (2006) Recoverin: a calcium-dependent regulator of the vusiual transduction. Neuronal Calcium Sensor Proteins (Philippov, P.P. and Koch, K.-W. Eds.) Nova Publishers, pp139-151

Koch, K.-W. (2006) Different biochemical properties of guanylate cyclase-activating proteins allow fine tuning of phototransduction. Neuronal Calcium Sensor Proteins (Philippov, P.P. and Koch, K.-W. Eds.) Nova Publishers, pp229-241

Nguyen-Duong,M., Koch K.-W., Merkel R. The Effect of Tethering on the
Chemical Kinetics of Single Bonds, in Dynamics in Small Confining Systems VIII, edited by John T. Fourkas, Pierre Levitz, René Overney, Michael Urbakh (Mater. Res. Soc. Symp. Proc. 899E, Warrendale ,PA , 2006), 0899-N03-01.

Neuronal Calcium Sensor Proteins (2006) Philippov, P.P. and Koch, K.-W. (Editors) Nova Publishers, Hauppauge, NY

Publikationen 2007

Gensch, T., Komolov, K.E., Senin, I.I., Philippov, P.P. and Koch, K.-W. (2007) Ca2+-dependent conformational changes in the neuronal Ca2+-sensor recoverin probed by the fluorescent dye Alexa647. PROTEINS: Structure, Function and Bioinformatics 65, 492-499

Helten, A. and Koch, K.-W. (2007) Calcium-dependent conformational changes in guanylate cyclase-activating protein 2 monitored by cysteine accessibility. Biochem. Biophys. Res. Commun. 356, 687-692

Helten, A., Säftel W. and K.-W. Koch (2007) Expression level and activity profile of membrane bound guanylate cyclase type 2 in rod outer segments. J. Neurochem.103, 1439-1446

Senin, I.S., Churumova, V.A., Philippov, P.P. and K.-W. Koch (2007) Membrane binding of the neuronal calcium sensor recoverin - modulatory role of the charged carboxyterminus. BMC Biochemistry 8: 24

Publikationen 2008

Koch, K.-W. and A. Helten (2008) Guanylate cyclase-based signaling in photoreceprors and retina. In: Signal Transduction in the Retina, Steven J. Flieser and Oleg G. Kisselev eds., CRC Press Taylor & Francis, chapter 6, 121-143 

Rätscho N., Scholten A. & Koch K.-W. (2008) Expression of Zebrafish Specific Neuronal Calcium Sensor Proteins Coincides with the Onset of Visual Function in the Larval Retina. Poster, Poster Prize at the 10th European Calcium Society Meeting Leuven, 2008

Enderlein, J., Dertinger, T., von der Hocht, I., Loman, A., Gregor, I.,Koch, K.-W., Komolov, K., Koberling, F., and Erdmann, R. (2008) Monitoring Of Small Conformational Changes By High-precision Measurements OfHydrodynamic Radius With 2-focus Fluorescence Correlation Spectroscopy (2ffcs). Biophys. J. 94: 183

Publikationen 2009

Behnen, P. Scholten, A. Rätscho, N. and Koch, K.-W. (2009) The cone-specific calcium sensor guanylate cyclase activating protein 4 from the zebrafish retina. J Biol Inorg Chem 14, 89-99  

Rätscho N., Scholten A. & Koch K.-W. (2009) Expression profiles of three novel sensory guanylate cyclasees and guanylate-activating proteins in the zebrafish retina. BBA- Molecular Cell Research 1793, 1110-1114

Komolov, K. E., Senin, I. I., Kovaleva, N. A., Christoph, M.P., Churumova, V.A., Grogoriev, I. I., Akhtar, M., Philippov, P. P. and Koch, K.-W. (2009) Mechanism of rhodopsin kinase regulation by recoverin. J Neurochem. 110, 72-79

Kitiratschky, V. B. D., Behnen, P., Kellner, U., Heckenlively, J. R., Zrenner, E., Jägle, H., Kohl, S., Wissinger, B. and Koch, K.-W. (2009) Mutations in the GUCA1A gene involved in hereditary cone dystrophies impair calcium-mediated regulation of guanlyate cyclase. Hum. Mutat. 30, E782-796

Koch, K.-W. (2009) Guanylate cyclase 2e. UCSD-Nature Molecule Pages. (doi:10.1038/mp.a000123.01)

Publikationen 2010

Koch, K.-W., Duda, T. and Sharma R. K. (2010) Ca2+ -modulated vision-linked ROS-GC guanylate cyclase transduction machinery. Mol Cell Biochem. 334, 105-115

Rätscho N., Scholten A., Koch, K.-W. (2010) Diversity of sensory guanylate cyclases in teleost fishes. Mol Cell Biochem. 334, 207-214

Dell'Orco, D., Behnen P., Linse, S. and Koch, K.-W. (2010) Calcium binding, structural stability and guanylate cyclase activation in GCAP1 variants associated with human cone dystrophy. Cell. Mol. Life. Sci. Mar; 67(6):973-84

Komolov, K. E. and Koch, K.-W. (2010) Application of surface plasmon resonance spectroscopy to study G-protein coupled receptor signalling. Methods Mol. Biol. 627:249-60

Fries, R., Reddy, P., P., Mikhaylova, M., Haverkamp, S., Wei, T., Müller, M., Kreutz. M. R. and Koch, K.-W. (2010) Dynamic cellular translocation of caldendrin is facilitated by the Ca2+ -myristoyl switch of recoverin. J Neurochem. 113, 1150-1162


Behnen, P., Dell'Orco, D. and Koch, K.-W. (2010) Involvement of the calcium sensor GCAP1 in hereditary cone dystrophies. Biol Chem. June, 391(6):631-637

Dell' Orco, D., Lundqvist, M.,Oslakovic, C., Cedervall, T., and S. Linse (2010) Modeling the Time Evolution of the Nanoparticle-Protein Corona in a Body Fluid. PLoS ONE Vol 5 (6), 1-8, e 10949

Dell'Orco, D., Müller, M. and Koch, K.-W. (2010) Quantitative detection of conformational transitions in a calcium sensor protein by surface plasmon resonance. ChemCommun. 46, 7316-7318 

Dell'Orco, D. and Koch, K.-W. (2010) Systems biochemistry approaches to vertebrate phototransduction: towards a molecular understanding of disease. Biochem Soc Trans. Oct. 38(5), 1275-1280 

Komolov, K. E., Aguilà, M., Toledo, D., Manyosa, J., Garriga, P. and K.-W. Koch (2010) On-chip photoactivation of heterologously expressed rhodopsin allows kinetic analysis of G-protein signaling by surface plasmon resonance spectroscopy. Anal Biochem Chem 397:2967-2976 

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