Prof. Dr. Karl-Wilhelm Koch
Tel.: +49-(0)441-798-3640
Office: W4 1-137

2017 - 2018

Publications 2017

Leyk J, Daly C, Janssen-Bienhold U, Kennedy BN, Richter-Landsberg C. (2017) HDAC6 inhibition by tubastatin A is protective against oxidative stress in a photoreceptor cell line and restores visual function in a zebrafish model of inherited blindness. Cell death & disease. 8(8):e3028.
doi: 10.1038/cddis.2017.415.

Koch, K.-W. (2017) GCAP (Guanylate cyclase-activating protein). Encyclopedia of Signaling Molecules, Second Edition (Ed. Sangdun Choi). Springer pp. 2041-2045.

Koch, K.-W. (2017) Guanylate Cyclase. Encyclopedia of Signaling Molecules, Second Edition (Ed. Sangdun Choi). Springer pp. 2294-2301.

Lim, S., Scholten, A., Manchala, G., Cudia, D., Zlomke-Sell, S.K., Koch, K.-W. and Ames, J.B. (2017) Structural Characterization of Ferrous Ion Binding to Retinal Guanylate Cyclase Activator Protein-5 from Zebrafish Photoreceptors. Biochemistry 56, 6652-6661.

Marino V, Borsatto A, Vocke F, Koch KW, Dell'Orco D. (2017) CaF2 nanoparticles as surface carriers of GCAP1, a calcium sensor protein involved in retinal dystrophies. Nanoscale. 2017 Aug 8. doi: 10.1039/c7nr03288a. [Epub ahead of print]

Sulmann S, Kussrow A, Bornhop DJ, Koch KW. (2017) Label-free quantification of calcium-sensor targeting to photoreceptor guanylate cyclase and rhodopsin kinase by backscattering interferometry. Sci Rep.7:45515. doi: 10.1038/srep45515.

Vocke F, Weisschuh N, Marino V, Malfatti S, Jacobson SG, Reiff C ., Dell’Orco D, Koch KW. (2017) Dysfunction of cGMP signaling in photoreceptors by a Macular Dystrophy-related mutation in the calcium sensor GCAP1. Hum. Mol. Genet. 26(1):133-144. doi: 10.1093/hmg/ddw374

Wallisch M, Sulmann S, Koch KW, Christoffers J. (2017) Bifunctional Diaminoterephthalate Fluorescent Dye as Probe for Cross-Linking Proteins. Chemistry. 23(27):6535-6543. doi: 10.1002/chem.201700774.

Publications 2018

Brand, I. and Koch, K.-W. (2018) Impact of the protein myristoylation on the structure of a model cell membrane in a protein bound state. Bioelectrochemistry 124, 13-21.

Brand, I., Matyszewska, D., Koch, K.-W.(2018) Binding of a Myristoylated Protein to the Lipid Membrane Influenced by Interactions with the Polar Head Group Region. Langmuir 34, 14022-14032.

Elbers, D., Scholten, A. and Koch, K.-W. (2018) Zebrafish recoverin isoforms display differences in calcium switch mechanisms. Front. Mol. Neurosci. 11:355. doi 10.3389/fnmol.2018.00355

Günther, A., Einwich, A., Sjulstok, E., Feederle, R., Bolte, P., Koch, K.-W., Solov’yov, I.A. and Mouritsen, H., (2018) Double-cone localisation and seasonal expression pattern suggest a role in magnetoreception for European robin cryptochrome 4. Curr. Biol. 28, 1-13.

Sharon, D., Wimberg, H., Kinarty, Y. and Koch, K.-W. (2018) Genotype-functional-phenotype correlations in photoreceptor guanylate cyclase (GC-E) encoded by GUCY2D. Prog. Retin. Eye Res. 63, 69-91.

Vladimirova, V.I., Zernii, E.Y., Baksheeva, V.E., Wimberg, H., Kazakov, A.S., Tikhomirova, N.K., Nemashkalova, E.L., Mitkevich, V.A., Zamyatnin Jr, A.A., Lipkin, V.M., Philippov, P.P., Permyakov, S.E., Senin, I,.I., Koch, K.-W., and Zinchenko, D.V. (2018) Photoreceptor calcium sensor proteins in detergent-resistant membrane rafts are regulated via binding to caveolin-1. Cell Calcium 73, 55-69.

Wimberg, H., Janssen-Bienhold, U. and Koch, K.-W. (2018) Control of the nucleotide cycle in photoreceptor cell extracts by retinal degeneration protein 3. Front. Mol. Neurosci. Vol. 11, article 52, 1-11. doi: 10.3389/fnmol.2018.00052

Wimberg, H., Lev, D., Yosovich, K., Namburi, P., Banin, E., Sharon, D. and Koch, K.-W. (2018) Photoreceptor Guanylate Cyclase (GUCY2D) mutations cause retinal dystrophies by severe malfunction of Ca2+-dependent cyclic GMP synthesis. Front. Mol. Neurosci.Vol. 11:348. doi: 10.3389/fnmol.2018.00348.

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