Local healthcare challenges in border regions force healthcare stakeholders to jointly think outside of the box in order to identify quick and efficient solutions in the region. Cross-border health cooperation creates the opportunity to solve problems smarter and opens the door to transform practices and healthcare structures, so that citizens living in border regions receive high quality and timely care. The CBI aims to facilitate the connection between the different heatlhcare stakeholders in both sides of the border in order to develop new cross-border healthcare initiatives and innovations.