Radulovic T, Rajaram E, Ebbers L, Pagella S, Winklhofer M, Kopp-Scheinpflug C, Nothwang HG, Milenkovic I, Hartmann AM (2023) Serine 937 phosphorylation enhances KCC2 activity and strengthens synaptic inhibition. Sci Rep doi: 10.1038/s41598-023-48884-x

Bordeynik-Cohen M, Sperber M, Ebbers L, Messika-Gold N, Krohs C, Koffler-Brill T, Noy Y, Elkon R, Nothwang HG, Avraham KB (2023) Shared and organ-specific gene-expression programs during the development of the cochlea and the superior olivary complex. RNA Biology. doi: 10.1080/15476286.2023.2247628

Pethe A, Hamze M, Giannaki M , Heimrich B, Medina I, Hartmann AM, Roussa E (2023) K⁺/Cl^- cotransporter (KCC2)/Na⁺/HCO^3- cotransporter 1 (NBCe1) interaction modulates profile of KCC2 phosphorylation, Frontiers in Cellular Neuroscience 17: doi: 10.3389/fncel.2023.1253424

Becker L, Hausmann J, and Hartmann AM (2023) Both chloride sites are important for KCC2 mediated transport, Journal of Biological Chemistry: 105190, doi.org/10.1016/j.jbc.2023.105190

Zhang J, Hartmann, AM, and Guo, J (2023) Chloride homeostasis in animal cell physiology. Frontiers in Physiology 14:1227565

Saleh AJ, Ahmed Y, Peters LO, Nothwang HG (2023) Comparative expression analysis of the Atoh7 gene regulatory network in the mouse and chicken auditory hindbrain. Cell and Tissue Research. doi: 10.1007/s00441-023-03763-9

Ebbers L, Altaf F, Nothwang HG (2022) MicroRNAs in the auditory system: tiny molecules with big impact Neuroforum. doi: 10.1515/nf-2022-0016

Hartmann AM, Nothwang HG (2022) NKCC1 and KCC2: Structural insights into phospho-regulation. Front Mol Neurosci.15:964488. doi: 10.3389/fnmol.2022.964488.

Saleeh, AJ, Nothwang HG. (2021) Differential expression of microRNAs in the developing avian auditory hindbrain. J Comp Neurol. 2021 529:3477-3496. doi: 10.1002/cne.25205

Krohs C, Körber C, Ebbers E, Altaf F, Hollje G, Hoppe S, Dörflinger Y, Prosser HM, Nothwang HG (2021) Loss of miR-183/96 alters synaptic strength via pre- and postsynaptic mechanisms at a central synapse. J. Neurosci, 41:6796-6811. doi: 10.1523/JNEUROSCI.0139-20.2021

Hartmann AM, Fu L, Ziegler C, Winklhofer M, Nothwang HG. (2021) Structural changes in the extracellular loop 2 of the murine KCC2 potassium chloride cotransporter modulate ion transport. J Biol Chem. 296:100793. doi: 10.1016/j.jbc.2021.100793

Schinzel F, Ebbers L, Nothwang HG (2021) The Lbx1 lineage differentially contributes to inhibitory cell types of the dorsal cochlear nucleus, a cerebellum like structure, and the cerebellum. J Comp Neurol, 529:3032-3045. doi: 10.1002/cne.25147

Krohs C, Bordeynik-Cohen M, Messika-Gold N, Elkon R, Avraham KB, Nothwang HG. (2021) Expression pattern of cochlear microRNAs in the mammalian auditory hindbrain. Cell Tissue Res. 383:655-666. doi: 10.1007/s00441-020-03290-x

Zhang J, Cordshagen A, Medina I, Nothwang HG, Wisniewski JR, Winklhofer M, Hartmann AM (2020) Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1. PLoS One 15:e0232967. doi: 10.1371/journal.pone.0232967

Claußen M, Schulze J, Nothwang HG. (2020) Loss of inner hair cell ribbon synapses and auditory nerve fiber regression in Cldn14 knockout mice. Hear Res. 391:107950. doi: 10.1016/j.heares.2020.107950

Schlüter T, Ebbers L, Nothwang HG (2017) Mehr als das Ohr – die Evolution des Hörsinns. BIOspektrum. 23. 638-640.

Ebbers L, Weber M, Nothwang HG (2017) Activity-dependent formation of a vesicular inhibitory amino acid transporter gradient in the superior olivary complex of NMRI mice. BMC Neurosci. 2017 18(1):75 ePub.

Wilms V, Söffgen C, Nothwang HG (2017) Differences in molecular mechanisms of K⁺ clearance in the auditory sensory epithelium of birds and mammals. J Exp Biol. 20:2701-2705.

Hartmann AM, Pisella LI, Medina I, Nothwang HG (2017) Molecular cloning and biochemical characterization of two cation chloride cotransporter subfamily members of Hydra vulgaris, PLoS ONE, 12:e0179968.

Nolte L, Tinne N, Schulze J, Heinemann D, Antonopoulos GC, Meyer H, Nothwang HG, Lenarz T, Heisterkamp A, Warnecke A, Ripken T. (2017). Scanning laser optical tomography for in toto imaging of the murine cochlea. PLoS ONE 12:e0175431

Bininda-Emonds, O.R.P., Hartmann, A.M., 2017. Mammalian Evolution: The Phylogenetics Story. In: Kaas, J (ed.), Evolution of Nervous Systems 2e. vol. 2, pp. 77–86

Ebbers L, Runge K, Nothwang HG. Differential patterns of histone methylase EHMT2 and its catalyzed histone modifications H3K9me1 and H3K9me2 during maturation of central auditory system. Cell Tissue Res. (2016) 365:247-264. 

Nothwang HG. Evolution of mammalian sound localization circuits: A developmental perspective. Prog Neurobiol. 2016 Mar 28. pii: S0301-0082(15)30020-4. doi: 10.1016/j.pneurobio.2016.02.003 .

Pawlik B, Schlüter T, Hartwich H, Breuel S, Heepmann L and Nothwang HG (2016). Comparative analysis of gene regulatory network components in the developing auditory hindbrain of mice and chicken. Brain Behav Evol 88:161-176

Wilms V, Köppl C, Söffgen C, Hartmann AM, Nothwang HG. (2016) Molecular bases of K+ secretory cells in the inner ear: shared and distinct features between birds and mammals. Sci Rep. 29;6:34203

Hartwich H, Rosengauer E, Rüttiger L, Wilms V, Waterholter SK, Nothwang HG (2016) Functional role of g-crystallin N in the auditory hindbrain. PLoS ONE 11:e0161140

Mahadevan V, Dargaei Z, Ivakine E, Hartmann AM, Ng D, Chevrier J, Ormond J, Nothwang HG, McInnes R, Woodin M. Neto2-null mice have impaired GABAergic inhibition and are susceptible to seizures. Front Cell Neurosci. 2015 Sep 23;9:368. doi: 10.3389/fncel.2015.00368. eCollection 2015.

Ebbers L, Satheesh SV, Janz K, Rüttiger L, Blosa M, Hofmann F, Morawski M, Griesemer D, Knipper M, Friauf E, Nothwang HG (2015) L-type calcium channel Cav1.2 is required for maintenance of auditory brainstem nuclei. J Biol Chem. jbc.M115.672675.

Llano O, Smirnov S, Soni S, Golubtsov A, Guillemin I, Hotulainen P, Medina I, Nothwang HG, Rivera C, Ludwig A (2015) KCC2 regulates actin dynamics in dendritic spines via interaction with β-PIX. J Cell Biol. 209: 671-86. 

Nothwang HG, Ebbers L, Schlüter T, Willaredt MA (2015) The emerging framework of mammalian auditory hindbrain development. Cell Tiss Res. 361:33-48, Erratum in 361:655 

Hartmann AM, Nothwang HG (2014) Molecular and evolutionary insights into the structural organization of cation chloride cotransporters. Front Cell Neurosci. 2015 Jan 21;8:470. doi: 10.3389/fncel.2014.00470. eCollection 2014.

Willaredt M, Schlüter T, Nothwang HG (2014) The gene regulatory networks underlying formation of the auditory hindbrain. Cell Mol Life Sci. 2015 Feb;72(3):519-35. doi: 10.1007/s00018-014-1759-0. Epub 2014 Oct 21

Weber M, Hartmann AM, Beyer T, Ripperger A, Nothwang HG. (2014)A novel regulatory locus of phosphorylation in the C-terminus of the potassium chloride cotransporter KCC2 that interferes with N-ethylmaleimide or staurosporine mediated activation. J Biol Chem. 289:18668-18679. Article of the week 

Willaredt M, Ebbers L, Nothwang HG (2014) Central auditory functions of deafness genes. Hear Res. 312C:9-20. 

Hartmann AM, Tesch D, Nothwang HG, Bininda-Emonds OR (2014) Evolution of the Cation Chloride Cotransporter Family: Ancient Origins, Gene Losses, and Subfunctionalization through Duplication. Mol Biol Evol. 31:434-447.

Zuccotti A, Lee SC, Campanelli D, Singer W, Satheesh SV, Patriarchi T, Geisler HS, Köpschall I, Rohbock K, Nothwang HG, Hu J, Hell JW, Schimmang T, Rüttiger L, Knipper M. (2013) L-type CaV1.2 deletion in the cochlea but not in the brainstem reduces noise vulnerability: implication for CaV1.2-mediated control of cochlear BDNF expression. Front Mol Neurosci. 2013;6:20. 

Ehmann H, Hartwich H, Salzig C, Hartmann N, Clement-Ziza M, Ushakov K, Avraham KB, Bininda-Emonds ORP, Hartmann AK, Lange P, Friauf E, Nothwang HG (2013) Time-dependent gene expression analysis of the developing superior olivary complex. J  Biol Chem. 288:25865-25879 

Kullmann L, Schlüter T, Wagner H, Nothwang HG (2013) Evolutionary Conservation of K_v3.1 in the Barn Owl Tyto alba. Brain Behav Evol. 81:187-193.

Schindler J, Ye J, Jensen ON, Nothwang HG. (2012) Monitoring the native phosphorylation state of plasma membrane proteins from a single mouse cerebellum.J Neurosci Methods. 2012 Dec 13. doi:pii: S0165-0270(12)00413-X. 10.1016/j.jneumeth.2012.10.003. [Epub ahead of print]
Rosengauer E., Hartwich H., Hartmann AM., Rudnicki A, Satheesh SV., Avraham KB, Nothwang HG. (2012) Egr2::cre mediated conditional ablation of dicer disrupts histogenesis of Mammalian central auditory nuclei. PLoS ONE 2012

Hartwich H, Satheesh SV, Nothwang HG (2012) A pink mouse reports the switch from red to green fluorescence upon Cre-mediated recombination. BMC Res Notes. 5(1):296. Satheesh SV, Kunert K, Rüttiger L, Zuccotti A, Schönig K, Friauf E, Knipper M, Bartsch D, Nothwang HG. (2012) Retrocochlear function of the peripheral deafness gene Cacna1d. Hum Mol Genet. PMID:22678062
Hartwich H, Nothwang HG. (2012) An easy and versatile 2-step protocol for targeted modification and subcloning of DNA from bacterial artificial chromosomes using non-commercial plasmids. BMC Res Notes. 5:156. Döding A, Hartmann AM, Beyer T, Nothwang HG. (2012) KCC2 transport activity requires the highly conserved L675 in the C-terminal β1 strand. Biochem Biophys Res Commun. 420(3):492-7.

Hirtz J., Boesen M., Braun N., Deitmer J., Kramer F., Lohr C., Müller B., Nothwang H.G., Striessnig J., Löhrke S., Friauf E. (2011) Cav1.3 calcium channels are required for normal development of the auditory brainstem. J. Neurosci, 31:8280-8294.
Hartmann A., Nothwang H.G. (2011) Opposite temperature effect on transport activity of KCC2/KCC4 and N(K)CCs in HEK-293 cells. BMC Res Notes. 4:526.

Müller CS, Haupt A, Bildl W, Schindler J, Knaus HG, Meissner M, Rammner B, Striessnig J, Flockerzi V, Fakler B, Schulte U. (2010) Feature Article: Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain. Proc Natl Acad Sci USA. 107(34):14950-7
Hartmann AM, Wenz M, Mercado A, Störger C, Mount DB, Friauf E, Nothwang HG.
Differences in the large extracellular loop between the K(+)-Cl(-) cotransporters KCC2 and KCC4. J Biol Chem. 2010 Jul 30;285(31):23994-4002

Apweiler R, Aslanidis C, Deufel T, Gerstner A, Hansen J, Hochstrasser D, Kellner R, Kubicek M, Lottspeich F, Maser E, Mewes HW, Meyer HE, Müllner S, Mutter W, Neumaier M, Nollau P, Nothwang HG, Ponten F, Radbruch A, Reinert K, Rothe G, Stockinger H, Tárnok A, Taussig MJ, Thiel A, Thiery J, Ueffing M, Valet G, Vandekerckhove J, Wagener C, Wagner O, Schmitz G.
Approaching clinical proteomics: current state and future fields of application in cellular proteomics.
Cytometry A. 2009 Oct;75(10):816-32.

Schindler J, Nothwang HG.
Isolation of plasma membranes from the nervous system by countercurrent distribution in aqueous polymer two-phase systems.
Methods Mol Biol. 2009;564:335-40.

Schindler J, Nothwang HG.
Enrichment of brain plasma membranes by affinity two-phase partitioning.
Methods Mol Biol. 2009;528: 119-26.

Nothwang HG, Schindler J.
Two-Dimensional Separation of Membrane Proteins by 16-BAC-SDS-PAGE.
Methods Mol Biol. 2009;528:269-77.

Becker, M., Nothwang, H.G. and Friauf, E.
Differential Proteomic analysis of the Inferior Colliculus and Cerebellum.
Neuroscience.2008 Jun 12;154:233-44.(pdf)

Ehmann H., Salzig C., Lang P., Friauf E. and Nothwang H.G.
Minimal sex differences in gene expression in the rat superior olivary complex.
Hearing Res. 2008 Nov;245:65-72 (pdf)

Schindler J, Lewandrowski U, Sickmann A, Friauf.
Aqueous polymer two-phase systems for the proteomic analysis of plasma membranes from minute brain samples.
J Proteome Res. 7:432-42 (link pub med)

Schindler J, Lewandrowski U., Sickmann A., Friauf E. and Nothwang H.G. (2006) Proteome Analysis of Brain Plasma Membranes Isolated by Affinity Two-Phase Partitioning. Mol Cell. Proteomics, 5:390-400. (pdf)

Nothwang, H.G., Koehl, A., and Friauf, E. (2006) Comparative gene expression profiling defines molecular requirements for the function of the superior olivary complex. Anat Rec A Discov Mol Cell Evol Biol. 288A:409-423. (pdf)

Schindler J, Jung, S, Niedner-Schatteburg G., Friauf E and Nothwang H.G. (2006) Enrichment of integral membrane proteins from small amounts of brain tissue.
J. Neural Transmission 113:995-1013. (pdf)

Wojcik SM, Katsurabayashi S, Guillemin I*, Friauf E, Rosenmund C, Brose N, Rhee JS (2006) A shared vesicular carrier allows synaptic co-release of GABA and glycine. Neuron 50:575-87. (pdf)

Becker M., Schindler J. and Nothwang H.G. (2006) Neuroproteomics - the tasks lying ahead. Electrophoresis 27:2819-2829. (pdf)

Schindler J and Nothwang H.G. (2006) Aqueous polymer two-phase systems: effective tools for plasma membrane proteomics. Proteomics 6:5409-5417. (pdf)

Blaesse P., Guillemin I., Schindler J, Schweizer M, Delpire E., Khiroug L., Friauf E. and Nothwang H.G. (2006) Oligomerization of KCC2 corrrelates with development of inhibitory neurotransmission. J.Neuroscience 26:10407-10419. (pdf)

Blaesse P., Friauf E. and Nothwang H.G. (2005) Developmental pattern of three vesicular glutamate transporters in the rat superior olivary complex. Cell Tissue Res. 320:33-50 (pdf)

Guillemin I., Becker M., Ociepka K., Friauf E. and Nothwang H.G. (2005) A subcellular prefractionation protocol for mammalian cells and tissues. Proteomics 5:35-45. (pdf)

Koehl A., Schmidt N., Rieger A., Letunic C., Pilgram S.M., Soto F., Bork P., Friauf E. and Nothwang, H.G. (2004) Transcriptome analysis of the rat superior olivary complex using SAGE. Eur. J. Neurosci. 20:3244-3258. (pdf)

Koehl A., Friauf E. and Nothwang H.G. (2003) Efficient cloning of SAGE tags by blunt-end ligation of polished concatemers. BioTechniques 34:692-694. (pdf)

Balakrishnan V., Becker M., Löhrke S., Nothwang H.G., Güresir E. and Friauf E. (2003) Expression and function of chloride transporters during the development of inhibitory neurotransmission in the rat auditory brainstem. J. Neurosci. 23:4134-4145. (pdf)

Nothwang H.G., Becker M., Ociepka K. and Friauf E. (2003) Protein analysis in the rat auditory brainstem by two-dimensional gel electrophoresis and mass spectrometry. Mol. Brain Res. 116:59-69. (pdf)

Becker M., Nothwang H.G. and Friauf E. (2003) Differential expression pattern of chloride transporters NCC, NKCC2, KCC1, KCC3, KCC4, and AE3 in the developing rat auditory brainstem. Cell Tissue Res. 312:155-165. (pdf)

Maroti Z., Kutsche K., Sutajova M., Gal A., Nothwang H.G., Czeizel A.E., Timar L. and Solyom E. (2002) Refinement and delineation of the breakpoint regions of a chromosome 1;22 translocation in a patient with Costello syndrome. Am. J. Med. Genet. 109:234-237.

Nothwang H.G., Hyung-Goo K., Kübart S., Menzel C., Wegner R.D., Ashworth L.K., Tommerup N., Ropers H.H and Wirth, J. (2001) Hemizygous disruption of PAFAH1B3 and Clk2, and presence of a fusion gene PAFAH1B3ex5/Clk2ex1, associated with mental retardation, ataxia and atrophy of the brain. Hum. Mol. Genet. 10:797-806.( pdf)

Wirth J., Back, E., Hüttenhofer A., Nothwang H.G., Lich C., Groß S., Menzel C., Schinzel A., Kioschis P., Tommerup N., Ropers H.H., Horsthemke B. and Buiting K. (2001). A translocation breakpoint cluster disrupts the newly defined 3' end of the SNURF-SNRPN transcription unit on chromosome 15. Hum. Mol. Genet. 10:201-210.

Bolz H., von Brederlow B., Ramirez A., Bryda E.C., Kutsche K., Nothwang H.G., Seeliger M., del Cabrera-Salcédo M., Caballero V.M., Pelaez Molina O., Gal A., Kubisch C. (2001) Mutations in cadherin-23 (otocadherin), a novel member of the cadherin gene family, cause Usher syndrome type 1D. Nature Genet. 27:108-112.

Omran H., Häffner K., Burth S., Fernandez C., Fargier B., Villaquiran A., Nothwang H.G., Schnittger S., Lehrach H., Woo D., Brandis M., Sudbrak R. and Hildebrandt F. (2001) Human adolescent nephronophthisis: gene locus synteny with polycystic kidney disease in pcy mice. J. Am. Soc. Nephrol. 12:107-113.

Borck G., Wirth J., Hardt T., Toennies H., Brøndum-Nielsen K., Bugge M., Tommerup N., Nothwang H.G., Ropers H.H., and Haaf T. (2001) Molecular cytogenetic characterization of a complex 46,XY,t(7;8;11;13) chromosome rearrangement in a patient with Moebius syndrome. J. Med. Genet. 38:117-121.

Nothwang H.G., Schröer A., van der Maarel S., Kübart S., Schneider S., Rießelmann L., Menzel C., Hinzmann B., Vogt D., Rosenthal A., Fryns J.P., Tommerup N., Haaf T., Ropers H.H. and Wirth J. (2000) Molecular cloning of Xp11 breakpoints in two unrelated mentally retarded females with X;autosome translocations. Cytogenet. Cell Genet. 90:126-133.

Scheer M.P., van der Maarel S., Kübart S., Schulz A., Wirth J., Schweiger S., Ropers H.H. and Nothwang H.G. (2000) DXS6673E encodes a predominantly nuclear protein and its mouse ortholog DxHXS6673E is alternatively spliced in a developmental- and tissue-specific manner. Genomics 63:123-132. (pdf)

Thiesen S., Kübart S., Ropers H.H. and Nothwang H.G. (2000) Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-211 and 2q22. Biophys. Biochem. Res. Com. 273:364-369. (pdf)

Kutsche K., Yntema H., Brand A., Jantke I., Nothwang H.G., Orth U., Boavida M.G., David D., Chelly J., Fryns J.P., Moraine C., Ropers H.H., van Bockhoven H. and Gal A. (2000) Mutations in PIX, encoding a guanine nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation. Nature Genet. 26:247-250.

Schröer A., Scheer M., Zacharias S., Schneider S., Ropers H.H., Nothwang H.G*., Chelly J., Hamel B., Fryns J.P., Shaw P. and Moraine C. (2000) Cosegregation of T108A ELK-1 with mental retardation. Am. J. Med. Genet. 95:404-405. *Korrespondierender Autor

Vollmer M., Kremer M., Ruf R., Miot S., Nothwang H.G., Wirth J., Otto E., Krapf R. and Hildebrandt, F. (2000) Molecular cloning of the criticial region for Glomerulopathy with Fibronectin deposits (GFND) and evaluation of candidate genes. Genomics 68:127-135.

Kutsche K., Glauner E., Knauf S., Pomarino A., Schmidt M., Schröder B., Nothwang H.G., Schüler H.M., Goecke T.O., Kersten A.J., Althaus C. and Gal A. (2000) Cloning and characterizsation of the breakpoint regions of a chromosome 11;18 translocation in a patient with hamartoma of the retinal pigment epithelium. Cytogenet. Cell Genet. 91:141-147.


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