Kontakt
Direktor
Universitätsklinik für Innere Medizin – Kardiologie
Sekretariat im Klinikum Oldenburg
Sekretariat Exp. Cardiology (Campus Wechloy)
Postanschrift Campus Wechloy
Besucheranschrift Campus Wechloy
Team
Principal Investigator
Short biography
Since 2020
Postdoc
Internal Medicine (Cardiology), Carl von Ossietzky University of Oldenburg, Germany
Project: Development of new material for vascular healing.
2018 – 2019
Postdoc
Laboratory of Genetics and Molecular Cardiology (LGCM – InCor/ HCFMUSP)
Project: Cardiac extracellular matrix as a target for the adipose stem cell therapy benefits post myocardial infarction.
2014 – 2018
PhD (Medical Science)
University of São Paulo (USP) – Brazil
Thesis: “Molecular mechanisms involved in endothelial phenotype in response to physical and chemical stimuli.” Supervisor: Dra Ayumi Aurea Miyakawa
2012 – 2014
Research Assistant
LGCM – InCor/ HCFMUSP
Projects: 1) Rapamycin activates TGF receptor independently of its ligand: implications for endothelial dysfunction 2) Effects of arterial level of stretch on human Saphenous Vein Endothelial Cell (hSVEC) phenotype
2007 – 2009
Master of Science
Federal University of São Paulo (UNIFESP) - Brazil
Thesis: “Stretching effects on human adipose stem cell: evaluation of phenotypic and molecular changes.” Supervisor: Dr Jose Eduardo Krieger
2004 – 2005
Scientific Internship
Physiology Department at UNIFESP
Project: Effects of leptin treatment in the central food intake regulation of rats
2002 – 2004
Scientific Internship
Biochemistry Department at UNIFESP
Project: Damages caused by alcohol in portal hypertension in rats
Publications
1. GIRÃO-SILVA, T*; FONSECA-ALANIZ, MH*; OLIVEIRA DALLAN, LA; VALADÃO, IC; OLIVEIRA DA ROCHA, GH; KRIEGER, JE; MIYAKAWA, AA. Human Saphenous Vein Endothelial Cell Isolation and Exposure to Controlled Levels of Shear Stress and Stretch. J Vis Exp. 2023 Apr 21;(194).
2. GIRÃO-SILVA, THAIS; LEE, JASON; PATIL, NIKITA P; DALLAN, LUIS A.O; BAKER, AARON B; HARMSEN, MARTIN C; KRIEGER, JOSE E; MIYAKAWA, AYUMI A. High stretch induces endothelial dysfunction accompanied by oxidative stress and actin remodeling in human saphenous vein endothelial cells. Sci Rep. 2021 Jun 29;11(1):13493.
3. MIYAKAWA AA, BORIN TF, CAMPOS LCG, GIRÃO-SILVA T, RIBEIRO-SILVA JC, DALLAN LAO, KRIEGER JE. Activation of Interleukin-1 Beta in Arterialized Vein Grafts and the Influence of the -511C/T IL-1β Gene Polymorphism. J Cardiovasc Dev Dis. 2019 Apr 30;6(2).
4. MIYAKAWA AA, BASSANEZE V, DUARTE NE, GIRÃO-SILVA T, BIZERRA MN, CAMPOS JC, KRIEGER JE. Temporal Change of Extracellular Matrix during Vein Arterialization Remodeling in Rats. J Cardiovasc Dev Dis. 2019 Feb 2;6(1).
5. MIYAKAWA AA*, GIRÃO-SILVA T*, KRIEGER JE, EDELMAN ER. Rapamycin activates TGF receptor independently of its ligand: implications for endothelial dysfunction. Clin Sci (Lond). 2018 Feb 16;132(4):437-447.
6. GIRÃO-SILVA, THAIS; BASSANEZE, VINICIUS; CAMPOS, LUCIENE CRISTINA; BARAUNA, VALERIO GARRONE; DALLAN, LUIS ALBERTO; KRIEGER, JOSE EDUARDO; MIYAKAWA, AYUMI AUREA. Short-term mechanical stretch fails to differentiate human adipose-derived stem cells into cardiovascular cell phenotypes. BiomedicalEngineering Online (Online), v. 13, p. 54, 2014.
7. TELLES, MÔNICA MARQUES; DA SILVA, THAÍS GIRÃO; WATANABE, REGINA LÚCIA HARUMI; DE ANDRADE, IRACEMA SENNA; ESTADELLA, DEBORA; NASCIMENTO, CLÁUDIA MARIA OLLER; OYAMA, LILA MISSAE; RIBEIRO, ELIANE BERALDI. Lateral hypothalamic serotonin is not stimulated during central leptinhypophagia. RegulatoryPeptides (Print), v. 184, p. 75-80, 2013.
8. NEUNEUKAMM, B.; MIYAKAWA, A. A.; FUKADA, S. Y.; ANDRADE, C.R.; PACHECO, F.P.; SILVA, T. G.; RAMALHO, L. N. Z.; OLIVEIRA, A. M.; KRIEGER, J. E. Local TAT-p27kip fusion protein inhibits cell proliferation in rat carotid arteries.Therapeutic Advances in Cardiovascular Disease, v. 2, p. 129-136, 2008.
Book Chapter
2021 – “Endothelial Signaling in Vascular Dysfunction and Disease: From Bench to Bedside”. Co-authorship with Silvia Lacchini and Ayumi A Miyakawa at 18th chapter: “Experimental models for identifying target events in vascular injury”. 1st Edition – Elsevier.
PhD Student
Short biography
Since 2023
PhD Student
Internal Medicine (Cardiology), Carl von Ossietzky University of Oldenburg, Germany
Project: Development of new material for vascular healing.
2022
Consulting advisor
Faculty of Veterinary Medicine, Islamic Azad University, Babol, Iran
Project: Study of the antibacterial and hemostatic properties of chitosan/alginate hydrogel with antibiotic.
2015– 2020
Master of Science in Biomedical Engineering-Biomaterials
Faculty of Medical Technologies-Department of Biomedical Engineering, Islamic Azad University, Science and Research branch, Tehran, Iran.
Project: Fabrication of PCL/Gelatin/NAGEL/ZnO bio composite for diabetic wound healing with 3D printing.
2011 – 2015
Bachelor of Science in Biomedical Engineering- Biomaterials
Islamic Azad University, Tonekabon branch, Tonekabon, Iran
Volunteer in:
2014(3 months)
Occupational therapy clinic
Tavana Occupational therapy clinic, Qaemshahr, Iran
2013(3 months)
Dental clinic
Amol Dental clinic, Amol, Iran
2012(3 months)
Hospital
Imam Khomeini Hospital, Sari, Iran
Publications
1. Sarkari S, Khajehmohammadi M, Davari N, Li D and Yu B. The effects of process parameters on polydopamine coatings employed in tissue engineering applications. Front. Bioeng. Biotechnol. 2022, 10:1005413. doi: 10.3389/fbioe.2022.1005413
2. Sahranavard, M;. Sarkari, S;. Safavi, S;. Ghorbani, F. Three-dimensional bio-printing of decellularized extracellular matrix-based bio-inks for cartilage regeneration: a systematic review. Biomater Transl. 2022, 3(2), 105-115.
3. Davari, N.; Bakhtiary, N.; Khajehmohammadi, M.; Sarkari, S.; Tolabi, H.; Ghorbani, F.; Ghalandari, B. Protein-Based Hydrogels: Promising Materials for Tissue Engineering. Polymers 2022, 14, 986. doi.org/10.3390/polym14050986
4. Fabrication of PCL/Gelatin biocomposite with 3D printing and comparison of mechanical properties with electrospinning's sample. Poster presentation at International Congress of Biomedicine, ICB2020.
5. Fabrication of PCL/gelatin/bio-active glass/ZnO biocomposite for diabetic wound healing with 3d printing. Presentation at International Conference on Technology Development in Chemical Engineering 2019.
Dr. med. Candidate
Short biography
Since 2022
Dr. med. Candidate
Internal Medicine (Cardiology), Carl von Ossietzky University of Oldenburg, Germany
Project: The effects of a biodegradable PLGA blend on Human Coronary Smooth
Muscle Cell phenotype.
Since 2017
Medical Studies at the Rostock University Medical Center
Student Assistant
Short biography
Since 2024
M.Sc. Molecular Biomedicine
Internal Medicine (Cardiology), Carl von Ossietzky University of Oldenburg, Germany
Project: Coating commercial stents to improve endothelial and smooth muscle cell adhesion
Technical Assistant
Short biography
Since 2024
Biological Science/ Technical Assistent
Internal Medicine (Cardiology), Carl von Ossietzky University of Oldenburg, Germany
Since 2008
Biological Science/ Technical Assistent
Neurosciences (Neurogenetics), Carl von Ossietzky University of Oldenburg, Germany
2005 - 2008
Biological Science Assistant
Neuronal Plasticity, Max-Planck Institute of Psychiatrie, Munich
2004
Biological Science Assistant
Molecular Genetics of behaviour, Max-Planck Institute of Psychiatrie, Munich
2001 - 2003
Accredited education as Biology technical assistant (BTA)
Berufsfachschule Oldenburg (IFBA, Die Schule)
Team Assistant
Former employees
Elisabeth Kagelmacher (from November 2019 – May 2023)
Dr. Damian McLeod (from April 2020 - Dez 2023)