Since 2020
Postdoc
Internal Medicine (Cardiology), Carl von Ossietzky University of Oldenburg, Germany
Project: Development of new material for vascular healing.

2018 – 2019
Postdoc
Laboratory of Genetics and Molecular Cardiology (LGCM – InCor/ HCFMUSP)
Project: Cardiac extracellular matrix as a target for the adipose stem cell therapy benefits post myocardial infarction. 

2014 – 2018
PhD (Medical Science)
University of São Paulo (USP) – Brazil
Thesis: “Molecular mechanisms involved in endothelial phenotype in response to physical and chemical stimuli.” Supervisor: Dra Ayumi Aurea Miyakawa

2012 – 2014
Research Assistant
LGCM – InCor/ HCFMUSP
Projects: 1) Rapamycin activates TGF receptor independently of its ligand: implications for endothelial dysfunction 2) Effects of arterial level of stretch on human Saphenous Vein Endothelial Cell (hSVEC) phenotype

2007 – 2009
Master of Science
Federal University of São Paulo (UNIFESP) - Brazil
Thesis: “Stretching effects on human adipose stem cell: evaluation of phenotypic and molecular changes.” Supervisor: Dr Jose Eduardo Krieger

2004 – 2005
Scientific Internship 
Physiology Department at UNIFESP
Project: Effects of leptin treatment in the central food intake regulation of rats

2002 – 2004
Scientific Internship
Biochemistry Department at UNIFESP
Project: Damages caused by alcohol in portal hypertension in rats

​​​​​​1.     GIRÃO-SILVA, T*; FONSECA-ALANIZ, MH*; OLIVEIRA DALLAN, LA; VALADÃO, IC; OLIVEIRA DA ROCHA, GH; KRIEGER, JE; MIYAKAWA, AA. Human Saphenous Vein Endothelial Cell Isolation and Exposure to Controlled Levels of Shear Stress and Stretch. J Vis Exp. 2023 Apr 21;(194).

2.    GIRÃO-SILVA, THAIS; LEE, JASON; PATIL, NIKITA P; DALLAN, LUIS A.O; BAKER, AARON B; HARMSEN, MARTIN C; KRIEGER, JOSE E; MIYAKAWA, AYUMI A. High stretch induces endothelial dysfunction accompanied by oxidative stress and actin remodeling in human saphenous vein endothelial cells. Sci Rep. 2021 Jun 29;11(1):13493.

3.    MIYAKAWA AA, BORIN TF, CAMPOS LCG, GIRÃO-SILVA T, RIBEIRO-SILVA JC, DALLAN LAO, KRIEGER JE. Activation of Interleukin-1 Beta in Arterialized Vein Grafts and the Influence of the -511C/T IL-1β Gene Polymorphism. J Cardiovasc Dev Dis. 2019 Apr 30;6(2).

4.    MIYAKAWA AA, BASSANEZE V, DUARTE NE, GIRÃO-SILVA T, BIZERRA MN, CAMPOS JC, KRIEGER JE. Temporal Change of Extracellular Matrix during Vein Arterialization Remodeling in Rats. J Cardiovasc Dev Dis. 2019 Feb 2;6(1).

5.    MIYAKAWA AA*, GIRÃO-SILVA T*, KRIEGER JE, EDELMAN ER. Rapamycin activates TGF receptor independently of its ligand: implications for endothelial dysfunction. Clin Sci (Lond). 2018 Feb 16;132(4):437-447. 

6.    GIRÃO-SILVA, THAIS; BASSANEZE, VINICIUS; CAMPOS, LUCIENE CRISTINA; BARAUNA, VALERIO GARRONE; DALLAN, LUIS ALBERTO; KRIEGER, JOSE EDUARDO; MIYAKAWA, AYUMI AUREA. Short-term mechanical stretch fails to differentiate human adipose-derived stem cells into cardiovascular cell phenotypes. BiomedicalEngineering Online (Online), v. 13, p. 54, 2014.

7.    TELLES, MÔNICA MARQUES; DA SILVA, THAÍS GIRÃO; WATANABE, REGINA LÚCIA HARUMI; DE ANDRADE, IRACEMA SENNA; ESTADELLA, DEBORA; NASCIMENTO, CLÁUDIA MARIA OLLER; OYAMA, LILA MISSAE; RIBEIRO, ELIANE BERALDI. Lateral hypothalamic serotonin is not stimulated during central leptinhypophagia. RegulatoryPeptides (Print), v. 184, p. 75-80, 2013.

8.    NEUNEUKAMM, B.; MIYAKAWA, A. A.; FUKADA, S. Y.; ANDRADE, C.R.; PACHECO, F.P.; SILVA, T. G.; RAMALHO, L. N. Z.; OLIVEIRA, A. M.; KRIEGER, J. E. Local TAT-p27kip fusion protein inhibits cell proliferation in rat carotid arteries.Therapeutic Advances in Cardiovascular Disease, v. 2, p. 129-136, 2008.

Book Chapter

2021 – “Endothelial Signaling in Vascular Dysfunction and Disease: From Bench to Bedside”. Co-authorship with Silvia Lacchini and Ayumi A Miyakawa at 18th chapter: “Experimental models for identifying target events in vascular injury”.  1st Edition – Elsevier.