Francis, B., Gozashti, L., Costello, K., Kasahara, T., Harringmeyer, O. S., Lilue, J., Helmy, M., Kato, T., Czechanski, A., Quail, M. A., Bonner, I., Dawson, E., Ferguson-Smith, A., Reinholdt, L., Adams, D. J., and Keane, T. M. The structural diversity of telomeres and centromeres across mouse subspecies revealed by complete assemblies. bioRxiv (2024) DOI: 10.1101/2024.10.24.619615
Nakamura, T., Yoshihara, T., Tanegashima, C., Kadota, M., Kobayashi, Y., Honda, K., Ishiwata, M., Ueda, J., Hara, T., Nakanishi, M., Takumi, T., Itohara, S., Kuraku, S., Asano, M., Kasahara, T., Nakajima, K., Tsuboi, T., Takata, A., and Kato, T. Transcriptomic dysregulation and autistic-like behaviors in Kmt2c haploinsufficient mice rescued by an LSD1 inhibitor. Mol. Psychiatry 29, 2888–2904 (2024) DOI: 10.1038/s41380-024-02479-8
Hagihara ,H., Shoji, H., Hattori, S., ... Kasahara, T., ... and Miyakawa, T. Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment. eLife 12, RP89376 (2024) DOI: 10.7554/eLife.89376
Yamamoto, H., Lee-Okada, H.C., Ikeda, M., Nakamura, T., Saito, T., Takata, A., Yokomizo, T., Iwata, N., Kato, T., and Kasahara, T. (Co-Corresponding author) GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice. Mol. Psychiatry 28, 2848–2856 (2023) DOI: 10.1038/s41380-023-01988-2
Kasahara, T. (Corresponding author), Mekada, K., Abe, K., Ashworth, A. and Kato, T. Complete sequencing of the mouse pseudoautosomal region, the most rapidly evolving ‘chromosome’ bioRxiv (2022) DOI: 10.1101/2022.03.26.485930
Sugawara, H., Bundo, N., Kasahara, T., Nakachi, Y., Ueda, J., Kubota-Sakashita, M., Iwamoto, K., and Kato, T. Cell-type-specific DNA methylation analysis of the frontal cortices of mutant Polg1 transgenic mice with neuronal accumulation of deleted mitochondrial DNA. Mol. Brain 15, 9 (2022).
Obata, Y., Kubota-Sakashita, M., Kasahara, T. (Co-Corresponding author), Mizuno, M., Nemoto, T., and Kato, T. Phenethylamine is a substrate of monoamine oxidase B in the paraventricular thalamic nucleus. Sci. Rep. 2, 17 (2021).
Kageyama, Y., Deguchi, Y., Kasahara, T., Tani, M., Kuroda, K., Inoue, K., and Kato, T. Intra-individual state-dependent comparison of plasma mitochondrial DNA copy number and IL-6 levels in patients with bipolar disorder. J. Affect. Disord. 299, 644–651 (2021).
Nakamura, T., Nakajima, K., Kobayashi, Y., Itohara, S., Kasahara, T., Tsuboi, T., and Kato, T. Functional and behavioral effects of de novo mutations in calcium-related genes in patients with bipolar disorder. Hum. Mol. Genet. 30, 1851–1862 (2021).
Zhang, C., Clough, S.J., Adamah-Biassi, E.B., Sveinsson, M.H., Hutchinson, A.J., Miura, I., Furuse, T., Wakana, S., Matsumoto, Y.K., Okanoya, K., Hudson, R.L., Kato, T., Dubocovich, M.L., and Kasahara, T. (Co-Corresponding author) Impact of endogenous melatonin on rhythmic behaviors, reproduction, and survival revealed in melatonin-proficient C57BL/6J congenic mice. J. Pineal Res. 71, e12748 (2021).
Bagge, E.K., Fujimori-Tonou, N., Kubota-Sakashita, M., Kasahara, T., and Kato, T. Unbiased PCR-free spatio-temporal mapping of the mtDNA mutation spectrum reveals brain region-specific responses to replication instability. BMC Biol. 18, 150 (2020).
Kasahara, T. (Co-Corresponding author), Kubota-Sakashita, M., Nagatsuka, Y., Hirabayashi, Y., Hanasaka, T., Tohyama, K., and Kato, T. Cardiolipin is essential for early embryonic viability and mitochondrial integrity of neurons in mammals. FASEB J. 34, 1465–1480 (2020).
Kageyama, Y., Kasahara, T., Kato, M., Sakai, S., Deguchi, Y., Tani, M., Kuroda, K., Hattori, K., Yoshida, S., Goto, Y., Kinoshita, T., Inoue, K., and Kato, T. The relationship between circulating mitochondrial DNA and inflammatory cytokines in patients with major depression. J. Affect. Disord. 233, 15–20 (2018).
Kageyama, Y., Kasahara, T., Nakamura, T., Hattori, K., Deguchi, Y., Tani, M., Kuroda, K., Yoshida, S., Goto, Y., Inoue, K., and Kato, T. Plasma nervonic acid is a potential biomarker for major depressive disorder: a pilot study. Int. J. Neuropsychopharmacol.21, 207–215 (2018).
Kasahara, T., Ishiwata, M., Kakiuchi, C., Fuke, S., Iwata, N., Ozaki, N., Kunugi, H., Minabe, Y., Nakamura, K., Iwata, Y., Fujii, K., Kanba, S., Ujike, H., Kusumi, I., Kataoka, M., Matoba, N., Takata, A., Iwamoto, K., Yoshikawa, T., and Kato, T. Enrichment of deleterious variants of mitochondrial DNA polymerase gene (POLG1) in bipolar disorder. Psychiatry Clin. Neurosci. 71, 518–529 (2017).
Kageyama, Y., Kasahara, T., Morishita, H., Mataga, N., Deguchi, Y., Tani, M., Kuroda, K., Hattori, K., Yoshida, S., Inoue, K., and Kato, T. Search for plasma biomarkers in drug-free patients with bipolar disorder and schizophrenia using metabolome analysis. Psychiatry Clin. Neurosci. 71, 115–123 (2017).
Kasahara, T., Takata, A., Kato, T.M., Kubota-Sakashita, M., Sawada, T., Kakita, A., Mizukami, H., Kaneda, D., Ozawa, K., and Kato, T. Depression-like episodes in mice harboring mtDNA deletions in paraventricular thalamus. Mol. Psychiatry 21, 39–48 (2016).
Fuke, S., Kametani, M., Yamada, K., Kasahara, T., Kubota-Sakashita, M., Kujoth, G.C., Prolla, T.A., Hitoshi, S., and Kato, T. Heterozygous Polg mutation causes motor dysfunction due to mtDNA deletions. Ann. Clin. Transl. Neurol. 1, 909–920 (2014).
Fuke, S., Kubota-Sakashita, M., Kasahara, T., Shigeyoshi, Y., and Kato, T. Regional variation in mitochondrial DNA copy number in mouse brain. Biochim. Biophys. Acta 1807, 270–274 (2011).
Kubota, M., Kasahara, T., Iwamoto, K., Komori, A., Ishiwata, M., Miyauchi, T., and Kato, T. Therapeutic implications of down-regulation of cyclophilin D in bipolar disorder. Int. J. Neuropsychopharmacol. 13, 1355–1368 (2010).
Kasahara, T. (Co-corresponding author), Abe, K., Mekada, K., Yoshiki, A., and Kato, T. Genetic variation of melatonin productivity in laboratory mice under domestication. Proc. Natl. Acad. Sci. USA. 107, 6412–6417 (2010).
Hayashi, A., Kasahara, T., Kametani, M., Toyota, T., Yoshikawa, T., and Kato, T. Aberrant endoplasmic reticulum stress response in lymphoblastoid cells from patients with bipolar disorder. Int. J. Neuropsychopharmacol. 4, 1–11 (2009).
Hayashi, A., Kasahara, T., Kametani, M., and Kato, T. Attenuated BDNF-induced upregulation of GABAergic markers in neurons lacking Xbp1. Biochem. Biophys. Res. Commun. 376, 758–763 (2008).
Kato, T., Ishiwata, M., Yamada, K., Kasahara, T., Kakiuchi, C., Iwamoto, K., Kawamura, K., Ishihara, H., and Oka, Y. Behavioral and gene expression analyses of Wfs1 knockout mice as a possible animal model of mood disorder. Neurosci. Res. 61, 143–153 (2008).
Kasahara, T. (Corresponding author), Kubota, M., Miyauchi, T., Ishiwata, M., and Kato, T. A marked effect of electroconvulsive stimulation on behavioral aberration of mice with neuron-specific mitochondrial DNA defects. PLoS ONE 3, e1877 (2008).
Hayashi, A., Kasahara, T., Iwamoto, K., Ishiwata, M., Kametani, M., Kakiuchi, C., Furuichi, T., and Kato, T. The role of brain-derived neurotrophic factor (BDNF)-induced XBP1 splicing during brain development. J. Biol. Chem. 282, 34525–34534 (2007).
Kubota, M., Kasahara, T., Nakmura, T., Ishiwata, M., Miyauchi, T., and Kato, T. Abnormal Ca2+ dynamics in transgenic mice with neuron-specific mitochondrial DNA defects. J. Neurosci. 26, 12314–12324 (2006).
Kasahara, T., Kubota, M., Miyauchi, T., Noda, Y., Mouri, A., Nabeshima, T., and Kato, T. Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes. Mol. Psychiatry 11, 577–593 (2006).
Kakiuchi, C., Iwamoto, K., Ishiwata, M., Bundo, M., Kasahara, T., Kusumi, I., Tsujita, T., Okazaki, Y., Nanko, S., Kunugi, H., Sasaki, T., and Kato, T. Impaired feedback regulation of XBP1 as a genetic risk factor of bipolar disorder. Nat. Genetics 35, 171–175 (2003).
Kasahara, T., and Kato, T. A new redox-cofactor vitamin for mammals. Nature 422, 832 (2003).
Kasahara, T., Okano, T., Haga, T., and Fukada, Y. Opsin–G11-mediated signaling pathway for photic entrainment of the chicken pineal circadian clock. J. Neurosci. 22, 7321–7325 (2002).
Okano, T., Yamamoto, K., Okano, K., Hirota, T., Kasahara, T., Sasaki, M., Takanaka, Y., and Fukada, Y. Chicken pineal clock genes: implication of BMAL2 as a bidirectional regulator in circadian clock oscillation. Genes Cells 6, 825–836 (2001).
Hirota, T., Kagiwada, S., Kasahara, T., Okano, T., Murata, M., and Fukada, Y. Effect of brefeldin A on melatonin secretion of chick pineal cells. J. Biochem. 129, 51–59 (2001).
Kasahara, T., Okano, T., Yoshikawa, T., Yamazaki, K., and Fukada, Y. Rod-type transducin alpha-subunit mediates a phototransduction pathway in the chicken pineal gland. J. Neurochem. 75, 217–224 (2000).
Matsushita, A., Yoshikawa, T., Okano, T., Kasahara, T., and Fukada, Y. Colocalization of pinopsin with two types of G-protein alpha-subunits in the chick pineal gland. Cell Tissue Res. 299, 245–251 (2000).
Okano, T., Yamazaki, K., Kasahara, T., and Fukada, Y. Molecular cloning of heterotrimeric G-protein alpha-subunits in chicken pineal gland. J. Mol. Evol. 44, S91–97 (1997).