Research assistants
Research assistants
Short biography
Current position
Since 2017 research associate in the Department of Anatomy in the Department of Human Medicine at the Carl von Ossietzky University Oldenburg
Academic training and scientific career
Since 2017 Research associate in the Department of Anatomy in the Department of Human Medicine at Carl von Ossietzky University Oldenburg
2012 - 2017 Research assistant for the teaching coordination of anatomy at the Faculty of Medicine and Health Sciences at Carl von Ossietzky University Oldenburg
Dec. 2010 Obtained specialist qualification in anatomy
2001 - 2012 Research assistant at the Institute of Anatomy at the University of Leipzig
2001 doctorate with the topic: "The changes of the oxygen partial pressure in the M. tibialis anterior of humans before, during and after tourniquet induced ischaemia".
Evaluation: magna cum laude
1998 - 2001 Research assistant in the Department of Anatomy and Cell Biology at Ulm University
1999 Licence to practise medicine
1997 - 1998 Internship in the Department of General Surgery at the University Hospital Regensburg
1989 - 1996 Medical studies at the University of Ulm and Regensburg
Memberships in scientific societies
- Neuroscience Society
- German Anatomical Society
Publications
Uslar V-N; Strotmann C; Ödemis V; Tabriz N; Salzmann D; Weyhe DA (2023): Anwendung von Augmented-Reality-Devices in der anatomischen Lehre in Abhängigkeit vom räumlichen Vorstellungsvermögen in der medizinischen Lehre zur Leber. In: Zeitschrift für Gastroenterologie Stuttgart [u.a.] : Thieme, 1997 Band 61 (2023), Nummer 8, Seite e609, insgesamt 1 Seite Online-Ressource. Online verfügbar unter www.thieme-connect.de/products/ejournals/conferencepdf/126907/10.1055/s-00000094.pdf.
Yahya I, Boeing M, Pu Q, Puchert M, Ödemis V, Engele J, Brand-Saberi B, Morosan-Puopolo G. CXCR4 and SDF-1 are critically involved in the formation of facial and non-somitic neck muscles. Scientific reports. 2020 10(1): 1-14.
Masyuk M, Abduelmula A, Morosan-Puopolo G, Ödemis V, Rehimi R, Khalida N, Yusuf F, Engele J, Tamamura H, Theiss C, Brand-Saberi B.: Retrograde migration of pectoral girdle muscle precursors depends on CXCR4/SDF-1 signaling. Histochem Cell Biol. 2014;142(5):473-88
Lipfert J., Ödemis V., Wagner DC., Boltze J., Engele J.: CXCR4 and CXCR7 form a functional receptor unit for SDF-1/CXCL12 in primary rodent microglia. Neuropathol Appl Neurobiol. 2013; 39(6): 667-80
Lipfert J., Ödemis V., Engele J.: Grk2 is an Essential Regulator of CXCR7 Signalling in Astrocytes. Cell Mol Neurobiol 2013; 33(1): 111-8
Hunger C., Ödemis V., Engele J.: Expression and function of the SDF-1 chemokine receptors CXCR4 and CXCR7 during limb muscle development and regeneration. Exp. Cell Res. 2012; 318: 2178–2190
Glisic D., Lehmann C., Figiel F., Ödemis V., Lindner R., Engele J.: A novel cross-talk between endothelin and ErbB receptors controlling glutamate uptake into astrocytes. J Neurochem. 2012; 122(4): 844-55
Ödemis V., Lipfert J., Kraft R., Hajek P., Abraham G., Hattermann K., Mentlein R., Engele J.: The presumed atypical chemokine receptor CXCR7 signals through Gi/o proteins in primary rodent astrocytes and human glioma cells. Glia 2012; 60 (3): 372–381
Ödemis V., Boosmann K., Küry P., Engele J.: CXCR7 is an active component of SDF-1 signalling in astrocytes and Schwann cells. J. Cell. Sci. 2010; 123(Pt 7): 1081-8
Göttle P., Kremer D., Jander S., Ödemis V., Engele J., Hartung HP, Küry P.: Activation of CXCR7 receptor promotes oligodendroglial cell maturation. Ann Neurol. 2010 Dec; 68(6): 915-24
Kolodziej A., Schulz S., Guyon, A., Wu D.F., Pfeiffer M., Ödemis V., Hollt V., Stumm R.:Tonic Activation of CXC Chemokine Receptor 4 in Immature Granule Cells Supports Neurogenesis in the Adult Dentate Gyrus. J. Neuroscience. 2008; 28 (17): 4488-4500
Ödemis V., Boosmann K., Dieterlen MT, Engele J.: The chemokine SDF-1 controls multiple steps of myogenesis through atypical PKCzeta.. J. Cell. Sci. 2007; 120(Pt 22): 4050-9
Ödemis V., Lamp E., Pezeshki G., Moepps B., Schilling K., Gierschik P., Littman DR, Engele J.: Mice deficient in the chemokine receptor CXCR4 exhibit impaired limb innervation and myogenesis. Mol. Cell. Neurosci. 2005; 30(4): 494-505
Ödemis V., Moepps B., Gierschik P., Engele J.: Interleukin-6 and cAMP induce stromal cell-derived factor-1 chemotaxis in astroglia by up-regulating CXCR4 cell surface expression. Implications for brain inflammation. J. Biol. Chem. 2002; 277(42): 39801-8
Ruf S., Ödemis V., Thasler W., Babl-Weisbarth M., Rose C.: Therapie der Pyoderma fistulans sinifica., Zbl Chir 1998;123:601
Evers B., Gerngroß H., Ödemis V.: Tourniquetischämie und intramuskulärer Sauerstoffpartialdruck bei Kniegelenksarthroskopien. In: Hartel W. (eds) Klinik und Forschung in der Chirurgie unter dem Aspekt von Effizienz und Ökonomie. Langenbecks Archiv für Chirurgie, vol 1997. Springer, Berlin, Heidelberg
Evers B., Ödemis V., Gerngross H.: Intramuscular oxygen partial pressure in patients with chronic exertional compartment syndrome (CECS). Adv. Exp. Med. Biol. 1997; 428: 311-316
Evers B., Ödemis V., Gerngross H.: Oxygen partial pressure in the anterior tibial muscle during and after knee surgery with tourniquet control. Adv. Exp. Med. Biol. 1997; 428: 317-325
Short biography
Current position
Since 2017 Research assistant in the Department of Anatomy in the Department of Human Medicine at Carl von Ossietzky University Oldenburg
Academic training and scientific career
Since 2017 Research assistant in the Department of Anatomy in the Department of Human Medicine at the Carl von Ossietzky University Oldenburg
2010 - 2016 Research associate at the Institute of Neuroanatomy, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf
2004 - 2009 Research Assistant at the Institute of Cell and Neurobiology, Center for Anatomy, Charité - Universitätsmedizin Berlin
Doctoral thesis: "The importance of CALEB/NGC for the differentiation of dendrite trees" Rating: summa cum laude
2003 - 2004 Research assistant in the Department of Cell Biology at the Zoological Institute, Technical University Carolo-Wilhelmina zu Braunschweig
1998 - 2003 Studies of Biology at the Technical University Carolo-Wilhelmina zu Braunschweig; Diploma thesis in the Department of Cell Biology at the Zoological Institute, Technical University Carolo-Wilhelmina zu Braunschweig
Diploma thesis: "Influence of phosphorylation of the microfilament protein profilin on its interaction with different ligands".
Memberships in scientific societies
- Neuroscience Society
- German Anatomical Society
Publications 2024
Brandt N, Köper F, Hausmann J, Bräuer AU. Spotlight on plasticity-related genes: Current insights in health and disease. Pharmacol Ther. 2024 Aug;260:108687. doi: 10.1016/j.pharmthera.2024.108687 . Epub 2024 Jul 3. PMID: 38969308 .
Publications 2022
Gray N, Limberg MM, Wiebe D, Weihrauch T, Langner A, Brandt N, Bräuer AU, Raap U. (2022) Differential Upregulation and Functional Activity of S1PR1 in Human Peripheral Blood Basophils of Atopic Patients. Int. J. Mol. Sci. 2022, 23(24), 16117; https://doi.org/10.3390/ijms232416117 (registering DOI).
Brandt N, Willmer JP,. Ayon-Olivas MS, Banicka V, Witt M, Wree A, Groß I, Gläser A, Hausmann J, Bräuer AU. (2022) PRG3 and PRG5 C-Termini: Important Players in Early Neuronal Differentiation. Int. J. Mol. Sci. 2022, 23, 13007.
Gross I, Brandt N, Vonk D, Köper F, Wöhlbrand L, Rabus R, Witt M, Heep A, Plösch T, Hipp MS, Bräuer AU. (2022) Plasticity-Related Gene 5 Is Expressed in a Late Phase of Neurodifferentiation After Neuronal Cell-Fate Determination. Front Cell Neurosci. 2022 Apr 15;16:797588. doi: 10.3389/fncel.2022.797588.
Van Bulck M, Brandt N, Claus RA, Graeler M, Braeuer AU (2022). Aβ-Induced Alterations in Membrane Lipids Occur before Synaptic Loss Appears. Int J Mol Sci. 2022 Feb 19;23(4):2300. doi: 10.3390/ijms23042300.
Publications 2020
Brandt N, Löffler T, Fester L,Rune GM (2020) Sex-specific features of spine densities in the hippocampus; Sci Rep 2020 Jul 9;10(1):11405. doi: 10.1038/s41598-020-68371
Brandt N, Fester L, Rune GM (2020) Neural sex steroids and hippocampal synaptic plasticity; Vitam Horm 2020 Jul 3 114:125-143. doi: 10.1016/bs.vh.2020.06.001.
Gläser A, Hammerl F, Gräler MH, Coldewey SM, Völkner C, Frech MJ, Yang F, Luo J, Tönnies E, von Bohlen Und Halbach O, Brandt N, Heimes D, Neßlauer AM, Korenke GC, Owczarek-Lipska M, Neidhardt J, Rolfs A, Wree A, Witt M, Bräuer AU. Identification of Brain-Specific Treatment Effects in NPC1 Disease by Focusing on Cellular and Molecular Changes of Sphingosine-1-Phosphate Metabolism. Int J Mol Sci. 2020 Jun 24;21(12):E4502. doi: 10.3390/ijms21124502.
Brandt N, Vierk R, Fester L, Anstötz M, Zhou L, Heilmann LF, Kind S, Steffen P, Rune GM (2019) Sex-specific Difference of Hippocampal Synaptic Plasticity in Response to Neurosteroids; Cereb Cortex 2020 Apr 14;30(4):2627-2641. doi: 10.1093/cercor/bhz265.
Publications 2019 and older
Brandt N, Rune GM (2019) Sex-dependency of oestrogen-induced structural synaptic plasticity: Inhibition of aromatase versus application of estradiol in rodents; Eur J Neurosci 2019 Aug 12. Doi: 10.1111/ejn.14541.
Meseke M, Pröls F, Schmahl C, Seebo K, Kruse C, Brandt N, Fester L, Zhou L, Bender R, Rune GM (2018) Reelin and aromatase cooperate in ovarian follicle development; Sci Rep 2018 Jun 7;8(1):8722. doi: 10.1038/s41598-018-26928-x.
Bender RA, Zhou L, Vierk R, Brandt N, Keller A, Gee CE, Schäfer MKE, Rune GM (2016) Sex-dependence of aromatase-mediated synaptic plasticity in the basolateral amygdala; J Neurosci, 2017;37(6):1532-1545.
Fester L, Brandt N, Windhorst S, Pröls F, Bläute C, Rune GM (2015) Control of aromatase in hippocampal neurons. J Steroid Biochem Mol Biol. 2015 Oct12. pii: S0960-0760(15)30109-6. doi: 10.1016/j.jsbmb.2015.10.009. [Epub ahead of print] Review.
Koester JD, Leggewie B, Blechner C, Brandt N, Fester L, Rune GM, Schweizer M, Kindler S, Windhorst S (2015) Inositol, 1,4,5- triphosphate-3kinase-A controls morphology of hippocampal dendritic spines. Cell Signal. 2015 Oct 28. pii: S0898-6568(15)00309-5. doi: 10.1016/j.cellsig.2015.10.016. [Epub ahead of print].
Brandt N, Vierk R, Fester L, Zhou L, Imholz P, Rune GM (2014) Gender and the effects of steroid hormones in the central nervous system. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2014 Sep;57(9):1054-60. doi: 10.1007/s00103-014-2014-4. German.
Vierk R, Brandt N, Rune GM (2014) Hippocampal estradiol synthesis and its significance for hippocampal synaptic stability in male and female animals. Neuroscience. 2014 May 15;274C:24-32. doi: 10.1016/j.neuroscience.2014.05.003. [Epub ahead of print] Review.
Zhou L, Fester L, Haghshenas S, de Vrese X, Hacht RV, Gloger S, Brandt N, Bader M, Vollmer G, Rune GM (2014) Oestradiol-induced synapse formation in the female hippocampus: roles of estrogen receptor subtypes. J Neuroendocrinol. 2014 Apr 30. doi: 10.1111/jne.12162. [Epub ahead of print].
Prange-Kiel J, Schmutterer T, Fester L, Zhou L, Imholz P, Brandt N, Vierk R, Jarry H, Rune GM (2013) Endocrine regulation of estrogen synthesis in the hippocampus? Prog Histochem Cytochem. 2013 Jul 29. doi:pii: S0079-6336(13)00013-2. 10.1016/j.proghi.2013.07.002. [Epub ahead of print].
Brandt N, Vierk R, Rune GM (2013) Sexual dimorphism in estrogen-induced synaptogenesis in the adult hippocampus. Int J Dev Biol. 2013;57(5):351-6. doi: 10.1387/ijdb.120217gr.
Vierk R, Glassmeier G, Zhou L, Brandt N, Fester L, Dudzinski D, Wilkars W, Bender RA, Lewerenz M, Gloger S, Graser L, Schwarz J, Rune GM (2012) Aromatase inhibition abolishes LTP generation in female mice by destabilizing the spine cytoskeleton. J Neurosci, 2012.
Wilkars W, Liu Z, Lewis AS, Stoub TR, Ramos EM, Brandt N, Nicholson DA, Chetkovich DM, Bender RA (2012) 1. Regulation of axonal HCN1 trafficking in perforant path involves expression of specific TRIP8b isoforms. PLoS One. 2012;7(2):e32181. Epub 2012 Feb 21.
Brandt N, Franke K, Johannes S, Buck F, Harder S, Hassel B, Nitsch R, and Schumacher S (2008) B56b, a regulatory subunit of protein phosphatase 2A, interacts with CALEB/NGC and inhibits CALEB/NGC-mediated dendritic branching. FASEB J, 2008 Jul;22(7):2521-33. Epub 2008 Apr 2.
Brandt N, Franke K, Rasin MR, Baumgart J, Vogt J, Khrulev S, Hassel B, Pohl EE, Sestan N, Nitsch R, and Schumacher S (2007) The neural EGF family member CALEB/NGC mediates dendritic tree and spine complexity. EMBO J 26, 2371-2386.
Short biography
Current position
Since 2021 Inter-faculty research assistant in anatomical teaching at the Carl von Ossietzky University Oldenburg
Academic training and scientific career
2018-2020 Research associate at the Institute of Anatomy and Cell Biology, Albert-Ludwigs-Universität Freiburg Research focus: interneuron development/epigenetics
2011- 2014 Marie Curie Fellow at the Department of Biomedical Science, Sheffield University, Sheffield, UK. research focus: inner ear development
2002-2010 PhD student/ research associate at the Umea Centre for Molecular Medicine, Umea Universitet, Umea, Sweden.
PhD 2009 PhD topic: "Early development of the olfactory placode and early rostrocaudal patterning of the caudal neural tube".
2002 Research assistant in the Department of Developmental Biology at Institute I of the Faculty of Biology, Albert-Ludwigs-University Freiburg.
1998 - 2002 Studies of Biology at the Albert-Ludwigs-University Freiburg; Diploma thesis in the Department of Developmental Biology at the Institute I of the Faculty of Biology of the Albert-Ludwigs-University Freiburg.
Diploma thesis: "Characterisation of the homeobox-encoding gene mnr2 in zebrafish".
1995-1998 Studied biology at the Friedrich Schiller University of Jena.
Publications
Baxendale S, Maier EC, Obholzer ND, Burbridge S, Zinski J, Tuazon FB, van Hateren NJ, Garcia Romero MM, Marzo M, Yokoya K, Knight RD, Megason SG, Mullins MC, Whitfield TT. (2023) Bmper is required for morphogenesis of the anterior and posterior semicircular canal ducts in the developing zebrafish inner ear. bioRxiv 2021.06.27.450014; doi: https://doi.org/10.1101/2021.06.27.450014
Maier EC, Whitfield T.: RA and FGF signalling are required in the zebrafish otic vesicle to pattern and maintain ventral otic identities, PLoS Genetics 2014 Dec 4;10(12).
Maier EC, Saxena A, Alsina B, Bronner ME, Whitfield T: Sensational placodes: Neurogenesis in the otic and olfactory system, Dev Biol. 2014 May 1;389(1).
Maier E, Nord H, von Hofsten J, Gunhaga L.: A balance of BMP and Notch activity regulates neurogenesis and olfactory nerve formation, PLoS ONE, 2011 Feb 23;6(2).
Maier E, von Hofsten J, Nord H, Fernandes M, Paek H, Hébert JM, Gunhaga L.: Opposing activities of FGF and BMP specify respiratory versus sensory olfactory epithelial cell fate decisions, Development. 2010 May;137 (10). (recommended by F1000).
Maier E, Gunhaga L: Dynamic expression of neurogenic markers in the developing chick olfactory epithelium, Dev Dyn. 2009, Jun;238(6).
Nordström U, Maier E, Jessell TM, Edlund T: An early role for Wnt signalling in specifying neural patterns of Cdx and Hox gene expression and motor neuron subtype identity, PLoS Biol. 2006, Jul 18;4(8).
Wendik B, Maier E, Meyer D: Zebrafish mnx genes in endocrine and exocrine pancreas formation, Dev Biol. 2004, Apr 15;268(2).
Short biography
Current position
Since 2022 Research Associate in the Department of Anatomy in the Department of Human Medicine at the Carl-von-Ossietzky University of Oldenburg
Academic training and scientific career
2017-2020 Marie Skłodowska-Curie Actions Fellow at the European Molecular Biology Laboratory in Heidelberg and Grenoble, and at the Department of Nuclear Medicine at Münster University Hospital.
2014-2016 EMBO Long-Term Scholar in the Department of Vascular Cell Biology at the Max Planck Institute for Molecular Biomedicine in Münster, Germany
2013-2014 Research Associate in the Department of Vascular Cell Biology at the Max Planck Institute for Molecular Biomedicine in Münster, Germany
2008-2013 Research associate (PhD student) in the Department of Biochemistry at the Netherlands Cancer Research Institute in Amsterdam Subject of PhD thesis: "Structural and biochemical characterisation of autotaxin".
2002-2008 Studied biology at the Westfälische Wilhelms University Münster, University of Michigan (USA) and at the University of Utrecht (The Netherlands) Thesis topic: "Characterisation of Hsp90 by segmental isotope labelling".
Publications
1. Brandt N, Köper F, Hausmann J, Bräuer AU. Spotlight on plasticity-related genes: Current insights in health and disease. Pharmacology & Therapeutics 260:108687, 2024
2. Eymery MC, Boumendjel A, McCarthy AA§, Hausmann J§. Linking the Autotaxin-LPA Axis to Medicinal Cannabis and the Endocannabinoid System. International Journal of Molecular Sciences 25 (6):3212, 2024
3. Eymery MC, Nguyen K, Basu S, Hausmann J, Nguyen VT, Seidel HS, Gutierrez L, Boumendjel A, McCarthy AA. Discovery of potent chromone-based autotaxin inhibitors inspired by cannabinoids. European Journal of Medicinal Chemistry 263:115944, 2023
4. Becker L, Hausmann J, Hartmann AM. Both chloride binding sites are required for KCC2 mediated-transport. Journal of Biological Chemistry 299(10):105190, 2023
Linking medicinal cannabis to autotaxin-lysophosphatidic acid signaling. Life Science Alliance 9;6(2):e202201595, 2023
6. Brandt N, Willmer JP, Ayon-Olivas MS, Banicka V, Witt M, Wree A, Groß I, Gläser A, Hausmann J, Bräuer AU. PRG3 and PRG5 C-Termini: Important Players in Early Neuronal Differentiation. International Journal of Molecular Science 23(21):13007, 2022
7. Hausmann J§, Joosten R, van Zeijl L, Hipgrave Ederveen AL, Moolenaar WH, Perrakis A§. Structural Snapshots of Autotaxin/ENPP2 and their implications for the catalysis. Journal of Structural Biology 195(2):199-206, 2016.
8. Keune WJ, Hausmann J*, Bolier R*, Tolenaars D, Kremer A, Heidebrecht T, Joosten R, Sunkara M, Morris AJ, Matas-Rico E, Moolenaar WH, Oude Elferink R§, Perrakis A§. Steroid binding to Autotaxin links bile salts and lysophosphatidic acid signaling. Nature Communication 7:11248, 2016.
9. Houben AJ, van Wijk XM, van Meeteren LA, van Zeijl L, van de Westerlo EM, Hausmann J, Fish A, Perrakis A, van Kuppevelt TH, and Moolenaar WH. The Polybasic Insertion in Autotaxin alpha Confers Specific Binding to Heparin and Cell Surface Heparan Sulfate Proteoglycans. Journal of Biological Chemistry 288(1): 510-519, 2013.
10. Hausmann J, Perrakis A, and Moolenaar WH. Structure-function relationships of autotaxin, a secreted lysophospholipase D. Advances in Biological Regulation 53(1): 112–117, 2013.
11. Kryshtafovych A, Moult J, Bartual SG, Bazan JF, Berman H, Casteel DE, Christodoulou E, Everett JK, Hausmann J, Heidebrecht T, Hills T, Hui R, Hunt JF, Seetharaman J, Joachimiak A, Kennedy MA, Kim C, Lingel A, Michalska K, Montelione GT, Otero JM, Perrakis A, Pizarro JC, van Raaij MJ, Ramelot TA, Rousseau F, Tong L, Wernimont AK, Young J, and Schwede T. Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction. Proteins79 Suppl 10: 6-20, 2011.
12. Albers HMHG, Hendrickx LJ, van Tol RJ, Hausmann J, Perrakis A, and Ovaa H. Structure-based design of novel boronic acid-based inhibitors of autotaxin. Journal of Medicinal Chemistry 54(13): 4619-4626, 2011.
13. Hausmann J*, Kamtekar S*, Christodoulou E, Day JE, Wu T, Fulkerson Z, Albers HMHG, van Meeteren LA, Houben AJ, van Zeijl L, Jansen S, Andries M, Hall T, Pegg LE, Benson TE, Kasiem M, Harlos K, Kooi CW, Smyth SS, Ovaa H, Bollen M, Morris AJ§, Moolenaar WH§, and Perrakis A§. Structural basis of substrate discrimination and integrin binding by autotaxin. Nature Structural & Molecular Biology 18: 198-204, 2011.
14. Karagoz GE, Duarte AM, Ippel H, Uetrecht C, Sinnige T, van Rosmalen M, Hausmann J, Heck AJ, Boelens R, and Rudiger SG. N-terminal domain of human Hsp90 triggers binding to the cochaperone p23. Proceedings of the National Academy of Sciences of the United States of America 108(2): 580-585, 2011.
15. Hausmann J*, Christodoulou E*, Kasiem M, De Marco V, van Meeteren LA, Moolenaar WH, Axford D, Owen RL, Evans G, and Perrakis A. Mammalian cell expression, purification, crystallization and microcrystal data collection of autotaxin/ENPP2, a secreted mammalian glycoprotein. Acta Crystallographica Section F 66(Pt 9): 1130-1135, 2010.
16. Day JE, Hall T, Pegg LE, Benson TE, Hausmann J, and Kamtekar S. Crystallization and preliminary X-ray diffraction analysis of rat autotaxin. Acta Crystallographica Section F 66(Pt 9): 1127-1129, 2010.
17. Cremers CM, Reichmann D, Hausmann J, Ilbert M, and Jakob U. Unfolding of metastable linker region is at the core of Hsp33 activation as a redox-regulated chaperone. The Journal of Biological Chemistry 285(15): 11243-11251, 2010.
* These authors contributed equally to the work
§ Shared corresponding authors