Contact

Prof. Dr. Anja U. Bräuer

Postal address

Faculty VI
Medicine and Health Sciences
Carl von Ossietzky University Oldenburg
Carl-von-Ossietzky Str. 9-11
26129 Oldenburg

Site plan

Insight into the anatomy

Scientific staff

PD Dr. med. Veysel Ödemis

+49 (0)441 798 3797

W34-0-009

Short biography

Current position

Since 2017
scientific assistant in the Department of Anatomy in the Department of Human Medicine at the Carl von Ossietzky University Oldenburg

Academic training and scientific career

Since 2017
Research associate in the Department of Anatomy in the Department of Human Medicine at Carl von Ossietzky University Oldenburg

2012 - 2017
Research assistant for the teaching coordination of anatomy at the Faculty of Medicine and Health Sciences at Carl von Ossietzky University Oldenburg

Dec. 2010
Obtained specialist qualification in anatomy

2001 - 2012
Research assistant at the Institute of Anatomy at the University of Leipzig

2001
doctorate with the topic: "The changes of the oxygen partial pressure in the M. tibialis anterior of humans before, during and after tourniquet induced ischaemia".

Evaluation: magna cum laude

1998 - 2001
Research assistant in the Department of Anatomy and Cell Biology at the University of Ulm

1999
Licence to practise medicine

1997 - 1998
Internship in the Department of General Surgery at the University Hospital Regensburg

1989 - 1996
Medical studies at the University of Ulm and Regensburg

Memberships in scientific societies

  • Neuroscience Society
  • German Anatomical Society

Publications

1. Yahya I, Boeing M, Pu Q, Puchert M, Ödemis V, Engele J, Brand-Saberi B, Morosan-Puopolo G. CXCR4 and SDF-1 are critically involved in the formation of facial and non-somitic neck muscles. Scientific reports. 2020 10(1): 1-14.

2. Masyuk M, Abduelmula A, Morosan-Puopolo G, Ödemis V, Rehimi R, Khalida N, Yusuf F, Engele J, Tamamura H, Theiss C, Brand-Saberi B.: Retrograde migration of pectoral girdle muscle precursors depends on CXCR4/SDF-1 signalling. Histochem Cell Biol. 2014;142(5):473-88

3. Lipfert J., Ödemis V., Wagner DC., Boltze J., Engele J.: CXCR4 and CXCR7 form a functional receptor unit for SDF-1/CXCL12 in primary rodent microglia. Neuropathol Appl Neurobiol. 2013; 39(6): 667-80

4. Lipfert J., Ödemis V., Engele J.: Grk2 is an Essential Regulator of CXCR7 Signalling in Astrocytes. Cell Mol Neurobiol 2013; 33(1): 111-8

5. Hunger C., Ödemis V., Engele J.: Expression and function of the SDF-1 chemokine receptors CXCR4 and CXCR7 during limb muscle development and regeneration. Exp. Cell Res. 2012; 318: 2178-2190

6. Glisic D., Lehmann C., Figiel F., Ödemis V., Lindner R., Engele J.: A novel cross-talk between endothelin and ErbB receptors controlling glutamate uptake into astrocytes. J Neurochem. 2012; 122(4): 844-55

7. Ödemis V., Lipfert J., Kraft R., Hajek P., Abraham G., Hattermann K., Mentlein R., Engele J.: The presumed atypical chemokine receptor CXCR7 signals through Gi/o proteins in primary rodent astrocytes and human glioma cells. Glia 2012; 60 (3): 372-381

8. Ödemis V., Boosmann K., Küry P., Engele J.: CXCR7 is an active component of SDF-1 signalling in astrocytes and Schwann cells. J. Cell. Sci. 2010; 123(Pt 7): 1081-8

9. Göttle P., Kremer D., Jander S., Ödemis V., Engele J., Hartung HP, Küry P.: Activation of CXCR7 receptor promotes oligodendroglial cell maturation. Ann Neurol. 2010 Dec; 68(6): 915-24

10. Kolodziej A., Schulz S., Guyon, A., Wu D.F., Pfeiffer M., Ödemis V., Hollt V., Stumm R.:Tonic Activation of CXC Chemokine Receptor 4 in Immature Granule Cells Supports Neurogenesis in the Adult Dentate Gyrus. J. Neuroscience. 2008; 28 (17): 4488-4500

11. Ödemis V., Boosmann K., Dieterlen MT, Engele J.: The chemokine SDF-1 controls multiple steps of myogenesis through atypical PKCzeta. J. Cell. Sci. 2007; 120(Pt 22): 4050-9.

12. Ödemis V., Lamp E., Pezeshki G., Moepps B., Schilling K., Gierschik P., Littman DR, Engele J.: Mice deficient in the chemokine receptor CXCR4 exhibit impaired limb innervation and myogenesis. Mol. Cell. Neurosci. 2005; 30(4): 494-505

13. Ödemis V., Moepps B., Gierschik P., Engele J.: Interleukin-6 and cAMP induce stromal cell-derived factor-1 chemotaxis in astroglia by up-regulating CXCR4 cell surface expression. Implications for brain inflammation. J. Biol. Chem. 2002; 277(42): 39801-8.

14. Ruf S., Ödemis V., Thasler W., Babl-Weisbarth M., Rose C.: Therapy of Pyoderma fistulans sinifica.., Zbl Chir 1998;123:601

15. Evers B., Gerngroß H., Ödemis V.: Tourniquet ischaemia and intramuscular oxygen partial pressure during knee arthroscopy. In: Hartel W. (eds) Klinik und Forschung in der Chirurgie unter dem Aspekt von Effizienz und Ökonomie. Langenbeck's Archives of Surgery, vol 1997. Springer, Berlin, Heidelberg.

16. Evers B., Ödemis V., Gerngross H.: Intramuscular oxygen partial pressure in patients with chronic exertional compartment syndrome (CECS). Adv. Exp. Med. Biol. 1997; 428: 311-316

17. Evers B., Ödemis V., Gerngross H.: Oxygen partial pressure in the anterior tibial muscle during and after knee surgery with tourniquet control. Adv. Exp. Med. Biol. 1997; 428: 317-325

Dr. rer. nat. Nicola Brandt

+49 (0)441 798 3797

W34-0-006

Short biography

Current position

Since 2017
Research assistant in the Department of Anatomy in the Department of Human Medicine at Carl von Ossietzky University Oldenburg

Academic training and scientific career

Since 2017
Research assistant in the Department of Anatomy in the Department of Human Medicine at the Carl von Ossietzky University Oldenburg

2010 - 2016
Research associate at the Institute of Neuroanatomy, Center for Experimental Medicine, University Medical Center Hamburg-Eppendorf

2004 - 2009
Research Assistant at the Institute of Cell and Neurobiology, Center for Anatomy, Charité - Universitätsmedizin Berlin

Doctoral thesis: "The importance of CALEB/NGC for the differentiation of dendrite trees" Rating: summa cum laude

2003 - 2004
Research assistant in the Department of Cell Biology at the Zoological Institute, Technical University Carolo-Wilhelmina zu Braunschweig

1998 - 2003
Studies of Biology at the Technical University Carolo-Wilhelmina zu Braunschweig; Diploma thesis in the Department of Cell Biology at the Zoological Institute, Technical University Carolo-Wilhelmina zu Braunschweig

Diploma thesis: "Influence of phosphorylation of the microfilament protein profilin on its interaction with different ligands".

Memberships in scientific societies

  • Neuroscience Society
  • German Anatomical Society

Publications

1. Gross I, Brandt N, Vonk D, Köper F, Wöhlbrand L, Rabus R, Witt M, Heep A, Plösch T, Hipp MS, Bräuer AU. (2022) Plasticity-Related Gene 5 Is Expressed in a Late Phase of Neurodifferentiation After Neuronal Cell-Fate Determination. Front Cell Neurosci. 2022 Apr 15;16:797588. doi: 10.3389/fncel.2022.797588.

2. Van Bulck M, Brandt N, Claus RA, Graeler M, Braeuer AU (2022). Aβ-Induced Alterations in Membrane Lipids Occur before Synaptic Loss Appears. Int J Mol Sci. 2022 Feb 19;23(4):2300. doi: 10.3390/ijms23042300.

3. Brandt N, Löffler T, Fester L,Rune GM (2020) Sex-specific features of spine densities in the hippocampus; Sci Rep 2020 Jul 9;10(1):11405. doi: 10.1038/s41598-020-68371

4. Brandt N, Fester L, Rune GM (2020) Neural sex steroids and hippocampal synaptic plasticity; Vitam Horm 2020 Jul 3 114:125-143. doi: 10.1016/bs.vh.2020.06.001.

5. Gläser A, Hammerl F, Gräler MH, Coldewey SM, Völkner C, Frech MJ, Yang F, Luo J, Tönnies E, von Bohlen Und Halbach O, Brandt N, Heimes D, Neßlauer AM, Korenke GC, Owczarek-Lipska M, Neidhardt J, Rolfs A, Wree A, Witt M, Bräuer AU. Identification of Brain-Specific Treatment Effects in NPC1 Disease by Focusing on Cellular and Molecular Changes of Sphingosine-1-Phosphate Metabolism. Int J Mol Sci. 2020 Jun 24;21(12):E4502. doi: 10.3390/ijms21124502.

6. Brandt N, Vierk R, Fester L, Anstötz M, Zhou L, Heilmann LF, Kind S, Steffen P, Rune GM (2019) Sex-specific Difference of Hippocampal Synaptic Plasticity in Response to Neurosteroids; Cereb Cortex 2020 Apr 14;30(4):2627-2641. doi: 10.1093/cercor/bhz265.

7. Brandt N, Rune GM (2019) Sex-dependency of estrogen-induced structural synaptic plasticity: inhibition of aromatase versus application of estradiol in rodents; Eur J Neurosci 2019 Aug 12. doi: 10.1111/ejn.14541.

8. Meseke M, Pröls F, Schmahl C, Seebo K, Kruse C, Brandt N, Fester L, Zhou L, Bender R, Rune GM (2018) Reelin and aromatase cooperate in ovarian follicle development; Sci Rep 2018 Jun 7;8(1):8722. doi: 10.1038/s41598-018-26928-x.

9. Bender RA, Zhou L, Vierk R, Brandt N, Keller A, Gee CE, Schäfer MKE, Rune GM (2016) Sex-dependence of aromatase-mediated synaptic plasticity in the basolateral amygdala; J Neurosci, 2017;37(6):1532-1545.

10. Fester L, Brandt N, Windhorst S, Pröls F, Bläute C, Rune GM (2015) Control of aromatase in hippocampal neurons. J Steroid Biochem Mol Biol. 2015 Oct12. pii: S0960-0760(15)30109-6. doi: 10.1016/j.jsbmb.2015.10.009. [Epub ahead of print] Review.

11. Koester JD, Leggewie B, Blechner C, Brandt N, Fester L, Rune GM, Schweizer M, Kindler S, Windhorst S (2015) Inositol, 1,4,5- triphosphate-3kinase-A controls morphology of hippocampal dendritic spines. Cell Signal. 2015 Oct 28. pii: S0898-6568(15)00309-5. doi: 10.1016/j.cellsig.2015.10.016. [Epub ahead of print].

12. Brandt N, Vierk R, Fester L, Zhou L, Imholz P, Rune GM (2014) Gender and the effects of steroid hormones in the central nervous system. Bundesgesundheitsblatt Health Research Health Protection. 2014 Sep;57(9):1054-60. doi: 10.1007/s00103-014-2014-4. German.

13. Vierk R, Brandt N, Rune GM (2014) Hippocampal estradiol synthesis and its significance for hippocampal synaptic stability in male and female animals. Neuroscience. 2014 May 15;274C:24-32. doi: 10.1016/j.neuroscience.2014.05.003. [Epub ahead of print] Review.

14. Zhou L, Fester L, Haghshenas S, de Vrese X, Hacht RV, Gloger S, Brandt N, Bader M, Vollmer G, Rune GM (2014) Oestradiol-induced synapse formation in the female hippocampus: roles of estrogen receptor subtypes. J Neuroendocrinol. 2014 Apr 30. doi: 10.1111/jne.12162. [Epub ahead of print].

15. Prange-Kiel J, Schmutterer T, Fester L, Zhou L, Imholz P, Brandt N, Vierk R, Jarry H, Rune GM (2013) Endocrine regulation of estrogen synthesis in the hippocampus? Prog Histochem Cytochem. 2013 Jul 29. doi:pii: S0079-6336(13)00013-2. 10.1016/j.proghi.2013.07.002. [Epub ahead of print].

16. Brandt N, Vierk R, Rune GM (2013) Sexual dimorphism in estrogen-induced synaptogenesis in the adult hippocampus. Int J Dev Biol. 2013;57(5):351-6. doi: 10.1387/ijdb.120217gr.

17. Vierk R, Glassmeier G, Zhou L, Brandt N, Fester L, Dudzinski D, Wilkars W, Bender RA, Lewerenz M, Gloger S, Graser L, Schwarz J, Rune GM (2012) Aromatase inhibition abolishes LTP generation in female mice by destabilizing the spine cytoskeleton. J Neurosci, 2012.

18. Wilkars W, Liu Z, Lewis AS, Stoub TR, Ramos EM, Brandt N, Nicholson DA, Chetkovich DM, Bender RA (2012) 1. Regulation of axonal HCN1 trafficking in perforant path involves expression of specific TRIP8b isoforms. PLoS One. 2012;7(2):e32181. Epub 2012 Feb 21.

19. Brandt N, Franke K, Johannes S, Buck F, Harder S, Hassel B, Nitsch R, and Schumacher S (2008) B56b, a regulatory subunit of protein phosphatase 2A, interacts with CALEB/NGC and inhibits CALEB/NGC-mediated dendritic branching. FASEB J, 2008 Jul;22(7):2521-33. Epub 2008 Apr 2.

20. Brandt N, Franke K, Rasin MR, Baumgart J, Vogt J, Khrulev S, Hassel B, Pohl EE, Sestan N, Nitsch R, and Schumacher S (2007) The neural EGF family member CALEB/NGC mediates dendritic tree and spine complexity. EMBO J 26, 2371-2386.

Dr. Joachim Hanke

+49 (0)441 798 3797

W34-0-007

Short biography

Current position

Since 2020
Scientific assistant in the Department of Anatomy in the Department of Human Medicine at the Carl von Ossietzky University Oldenburg

Academic training and scientific career

2001 - 2006
Scientific Assistant at the Institute of Anatomy of the Medical Faculty in Magdeburg

1999 - 2001
Scientific Assistant at the Institute of Medical Psychology of the Medical Faculty in Magdeburg

1996 - 1999
Research Assistant at the Institute of Anatomy at the Medical University of Hannover

1995 - 1996
Research Assistant at the Institute of Anatomy of the Medical Faculty in Frankfurt a.M.

1993 - 1994
Research assistant in the Department of Zoophysiology at the University of Oldenburg

1990 - 1993
Scholarship holder of the State of Lower Saxony as doctoral student in the department Zoophysiology of the University of Oldenburg

Doctoral thesis: Localisation, characterisation and isolation of the opiate receptor in crustaceans Rating: summa cum laude

1985 - 1990
Study of Biology at the University of Oldenburg, Grade Point Average: 1.0
Diploma Thesis: Autoradiographic and immunocytochemical investigations of ultramicroscopic structures of the neuroendocrine system of crustaceans

Publications

  1. Wickramasekaraa, Rochelle N.; Bockman, Charles; Hanke, Joachim; Schwegler, Herbert; McGeed, JoAnn; Walsh, Edward; Yilmazer-Hanke, Deniz. (2020). Alpha2-adrenergic dysregulation in congenic DxH recombinant inbred mice selectively bred for a high fear-sensitized (H-FSS) startle response. Pharmacology, Biochemistry and Behaviour. 188. 172835
     
  2. Yilmazer-Hanke, Deniz; Eliava, Marina; Hanke, Joachim; Schwegler, Herbert; Asan, Esther. (2016). Density of Acetylcholine Esterase (AchE) and Tyrosine Hydroxylase (TH) Containing Fibers in the Amygdala of Roman High- and Low-Avoidance Rats. Neuroscience letters. 632. 114-8.
     
  3. Browne, Caroline; Hanke, Joachim; Rose, Claudia; Walsh, Irene; Foley, Tara; Clarke, Gerard;Schwegler, Herbert; Cryan, John; Yilmazer-Hanke, Deniz. (2014). Effect of Acute Swim Stress on Plasma Corticosterone and Brain Monoamine Levels in Bidirectionally Selected DxH Recombinant Inbred Mouse Strains Differing in Fear Recall and Extinction. Stress (Amsterdam, Netherlands). 17. 1-36.
     
  4. Browne, Caroline; Clarke, Gerard; Hanke, Joachim; G Dinan, Timothy; Schwegler, Herbert; Yilmazer-Hanke, Deniz; Cryan, John. (2013). Alterations in prefrontal cortical serotonin and antidepressant-like behaviour in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain. Behavioural brain research. 236. 283-8.
     
  5. Rose, Claudia; Schwegler, Herbert; Hanke, Joachim; Yilmazer-Hanke, Deniz. (2012). Pregnancy rates, prenatal and postnatal survival of offspring, and litter sizes after reciprocal embryo transfer in DBA/2JHd, C3H/HeNCrl and NMRI mice. Theriogenology. 77. 1883-93.
     
  6. Frisch, Christian; Hanke, Joachim; Kleinerüschkamp, Sven; Roeske, Sandra; Kaaden, Sabine; Elger, Christian; Schramm, Johannes; Yilmazer-Hanke, Deniz; Helmstaedter, Christoph. (2009). Positive Correlation Between the Density of Neuropeptide Y Positive Neurons in the Amygdala and Parameters of Self-Reported Anxiety and Depression in Mesiotemporal Lobe Epilepsy Patients. Biological psychiatry. 66. 433-40.
     
  7. Rose, Claudia; Röhl, Friedrich-Wilhelm; Hanke, Joachim; Schwegler, Herbert; Yilmazer-Hanke, Deniz. (2008). Maternal and Genetic Effects on the Acoustic Startle Reflex and its Sensitization in C3H/HeN, DBA/2JHd and NMRI Mice Following Blastocyst Transfer. Behaviour genetics. 38. 596-611.
     
  8. Rose, Claudia; Schwegler, Herbert; Hanke, Joachim; Röhl, Friedrich-Wilhelm; Yilmazer-Hanke, Deniz. (2006). Differential effects of embryo transfer and maternal factors on anxiety-related behaviour and numbers of neuropeptide Y (NPY) and parvalbumin (PARV) containing neurons in the amygdala of inbred C3H/HeN and DBA/2J mice. Behavioural brain research. 173. 163-8.
     
  9. Rose, Claudia; Röhl, Friedrich-Wilhelm; Schwegler, Herbert; Hanke, Joachim; Yilmazer-Hanke, Deniz. (2006). Maternal and Genetic Effects on Anxiety-Related Behavior of C3H/HeN, DBA/2J and NMRI Mice in a Motility-Box Following Blastocyst Transfer. Behaviour genetics. 36. 745-62.
     
  10. Roskoden, Thomas; Hanke, Joachim; Yilmazer-Hanke, Deniz; Schwegler, Herbert. (2005). Reduced number of CRF-containing neurons in the central amygdala correlated with enhanced locomotor activity following early postnatal corticosterone treatment in the Wistar rat. Behavioural brain research. 165. 221-8.
     
  11. Yilmazer-Hanke, Deniz; Hantsch, M; Hanke, Joachim; Schulz, Carla; Faber-Zuschratter, Heidi; Schwegler, Herbert. (2004). Neonatal thyroxine treatment: Changes in the number of corticotropinreleasing-factor (CRF) and neuropeptide Y (NPY) containing neurons and density of tyrosine hydroxylase positive fibres (TH) in the amygdala correlate with anxiety-related behaviour of Wistar rats. Neuroscience. 124. 283-97.
     
  12. Hanke, JoachimSabel, Bernhard. (2004). L-type calcium channel antagonist nifedipine reduces neurofilament restitution following traumatic optic nerve injury. Acta neurochirurgica. Supplement. 89. 75-80.
     
  13. Hanke, JoachimSabel, Bernhard. (2002). Anatomical correlations of intrinsic axon repair after partial optic nerve crush in rats. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomical Society. 184. 113-23.
     
  14. Hanke Joachim (2001) Apoptosis in cultured islets of Langerhans and occurrence of Bcl-2, Bak, Bax, Fas and FasL. Cell Tissues Organs 169: 113-124.
     
  15. Hanke Joachim (2000) Apoptosis and occurrence of Bcl-2, Bak, Bax, Fas and FasL in the developing and adult rat endocrine pancreas. Anat Embryol 202: 303-312.
     
  16. Yilmazer-Hanke D, Hanke J (1999): Progression of Alzheimer-related neuritic plaque pathology in the entorhinal region, perirhinal cortex, and hippocampal formation. Dement Geriatr Cogn Disord 10: 70-76.
     
  17. Nagy Z, Yilmazer DM, Braak H, Braak E, Schultz C, Hanke J (1998): Assessment of the pathological stages of Alzheimer's disease in thin paraffin sections: A comparative study. Dement Geriatr Cogn Disord 9: 140-144.
     
  18. Nagy Z, Vatter-Bittner B, Braak H, Braak E, Yilmazer DM, Schultz C, Hanke J (1997): Staging of Alzheimer-type pathology: An interrater-intrarater study. Dement Geriatr Cogn Disord 8: 248-251.
     
  19. Hanke J, Yilmazer-Hanke DM (1997): Pigmentarchitectonic subfields of the entorhinal region as revealed in tangential sections. J Brain Res 38: 427-432.
     
  20. Hanke JYilmazer-Hanke DM (1997): Variabilities in the distribution of neurofibrillary tangles in the anterior parahippocampal gyrus at initial stages of Alzheimer's disease. Clin. Neuropathol 16: 299-302.
     
  21. Hanke J (1997) Sulcal pattern of the anterior parahippocampal gyrus in the human adult. Ann Anat 179: 335-339.
     
  22. Hanke JWillig A, Yinon U, Jaros PP (1997): Delta and kappa opioid receptors in eyestalk ganglia of a crustacean. Brain Res. 744: 279-284.
     
  23. Hanke JWillig A, Jaros PP (1996): Opioid receptor types for endogenous enkephalin in the thoracic ganglion of the crab, Carcinus maenas. Peptides 17: 965-972.
     
  24. Hanke J, Jaros PP, Willig A (1993): Ultrastructural autoradiographic localization of opiod receptors on membranes with CHH immunogold detected axon terminals in a neurohemal organ of Carcinus maenas L.. Histochem. 99: 405-410.
     
  25. Hanke J, Jaros PP, Willig A (1992): Differential localization of leu-enkephalin in axon terminals of the sinus gland of the crabs Carcinus maenas L., Eriocheir sinensis and Uca pugilator. Cell Tissue Res. 270: 521-526.

Inter-faculty staff member

PhD Esther Maier

+49 (0)441 798-3797

W34-0-007

Short biography

Current position

Since 2021
Inter-faculty research assistant in anatomical teaching at the Carl von Ossietzky University Oldenburg

Academic training and scientific career

2018-2020
Research associate at the Institute of Anatomy and Cell Biology, Albert-Ludwigs-Universität Freiburg Research focus: interneuron development/epigenetics

2011- 2014
Marie Curie Fellow at the Department of Biomedical Science, Sheffield University, Sheffield, UK. research focus: inner ear development

2002-2010
PhD student/ research associate at the Umea Centre for Molecular Medicine, Umea Universitet, Umea, Sweden.

PhD 2009
PhD topic: "Early development of the olfactory placode and early rostrocaudal patterning of the caudal neural tube".

2002
Research assistant in the Department of Developmental Biology at Institute I of the Faculty of Biology, Albert-Ludwigs-University Freiburg.

1998 - 2002
Studies of Biology at the Albert-Ludwigs-University Freiburg; Diploma thesis in the Department of Developmental Biology at the Institute I of the Faculty of Biology of the Albert-Ludwigs-University Freiburg.

Diploma thesis: "Characterisation of the homeobox-encoding gene mnr2 in zebrafish".

1995-1998
Studied biology at the Friedrich Schiller University of Jena.

Publications

1. Maier EC, Whitfield T.: RA and FGF signalling are required in the zebrafish otic vesicle to pattern and maintain ventral otic identities, PLoS Genetics 2014 Dec 4;10(12).

2. Maier EC, Saxena A, Alsina B, Bronner ME, Whitfield T: Sensational placodes: Neurogenesis in the otic and olfactory system, Dev Biol. 2014 May 1;389(1).

3. Maier E, Nord H, von Hofsten J, Gunhaga L.: A balance of BMP and Notch activity regulates neurogenesis and olfactory nerve formation, PLoS ONE, 2011 Feb 23;6(2).

4. Maier E, von Hofsten J, Nord H, Fernandes M, Paek H, Hébert JM, Gunhaga L.: Opposing activities of FGF and BMP specify respiratory versus sensory olfactory epithelial cell fate decisions, Development. 2010 May;137 (10). (recommended by F1000).

5. Maier E, Gunhaga L: Dynamic expression of neurogenic markers in the developing chick olfactory epithelium, Dev Dyn. 2009, Jun;238(6).

6. Nordström U, Maier E, Jessell TM, Edlund T: An early role for Wnt signalling in specifying neuralpatterns of Cdx and Hox gene expression and motor neuron subtype identity, PLoS Biol. 2006, Jul 18;4(8).

7. Wendik B, Maier E, Meyer D: Zebrafish mnx genes in endocrine and exocrine pancreas formation, Dev Biol. 2004, Apr 15;268(2).

Dr Jens Hausmann

+49 (0)441 798-3797

W34-0-007

Short biography

Current position

Since 2022 Research Associate in the Department of Anatomy in the Department of Human Medicine at the Carl-von-Ossietzky University of Oldenburg

Academic training and scientific career

2017-2020 Marie Skłodowska-Curie Actions Fellow at the European Molecular Biology Laboratory in Heidelberg and Grenoble, and at the Department of Nuclear Medicine at Münster University Hospital.

2014-2016 EMBO Long-Term Scholar in the Department of Vascular Cell Biology at the Max Planck Institute for Molecular Biomedicine in Münster, Germany

2013-2014 Research Associate in the Department of Vascular Cell Biology at the Max Planck Institute for Molecular Biomedicine in Münster, Germany

2008-2013 Research associate (PhD student) in the Department of Biochemistry at the Netherlands Cancer Research Institute in Amsterdam Subject of PhD thesis: "Structural and biochemical characterisation of autotaxin".

2002-2008 Studied biology at the Westfälische Wilhelms University Münster, University of Michigan (USA) and at the University of Utrecht (The Netherlands) Thesis topic: "Characterisation of Hsp90 by segmental isotope labelling".

Publications

1 Hausmann J§, Joosten R, van Zeijl L, Hipgrave Ederveen AL, Moolenaar WH, Perrakis A§. Structural snapshots of autotaxin/ENPP2 and their implications for the catalysis. Journal of Structural Biology 195(2):199-206, 2016.

Keune WJ, Hausmann J*, Bolier R*, Tolenaars D, Kremer A, Heidebrecht T, Joosten R, Sunkara M, Morris AJ, Matas-Rico E, Moolenaar WH, Oude Elferink R§, Perrakis A§. Steroid binding to autotaxin links bile salts and lysophosphatidic acid signalling. Nature Communication 7:11248-1-10, 2016.

Houben AJ, van Wijk XM, van Meeteren LA, van Zeijl L, van de Westerlo EM, Hausmann J, Fish A, Perrakis A, van Kuppevelt TH, and Moolenaar WH. The Polybasic Insertion in Autotaxin alpha Confers Specific Binding to Heparin and Cell Surface Heparan Sulfate Proteoglycans. The Journal of Biological Chemistry 288: 510-519, 2013.

Hausmann J, Perrakis A, and Moolenaar WH. Structure-function relationships of autotaxin, a secreted lysophospholipase D. Advances in Biological Regulation 53 (2013) 112-117.

5. Kryshtafovych A, Moult J, Bartual SG, Bazan JF, Berman H, Casteel DE, Christodoulou E, Everett JK, Hausmann J, Heidebrecht T, Hills T, Hui R, Hunt JF, Seetharaman J, Joachimiak A, Kennedy MA, Kim C, Lingel A, Michalska K, Montelione GT, Otero JM, Perrakis A, Pizarro JC, van Raaij MJ, Ramelot TA, Rousseau F, Tong L, Wernimont AK, Young J, and Schwede T. Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction. Proteins 79 Suppl 10: 6-20, 2011.

Albers HMHG, Hendrickx LJ, van Tol RJ, Hausmann J, Perrakis A, and Ovaa H. Structure-based design of novel boronic acid-based inhibitors of autotaxin. Journal of Medicinal Chemistry 54: 4619-4626, 2011.

7 Hausmann J*, Kamtekar S*, Christodoulou E, Day JE, Wu T, Fulkerson Z, Albers HMHG, van Meeteren LA, Houben AJ, van Zeijl L, Jansen S, Andries M, Hall T, Pegg LE, Benson TE, Kasiem M, Harlos K, Kooi CW, Smyth SS, Ovaa H, Bollen M, Morris AJ§, Moolenaar WH§, and Perrakis A§. Structural basis of substrate discrimination and integrin binding by autotaxin. Nature Structural & Molecular Biology 18: 198-204, 2011.

Karagoz GE, Duarte AM, Ippel H, Uetrecht C, Sinnige T, van Rosmalen M, Hausmann J, Heck AJ, Boelens R, and Rudiger SG. N-terminal domain of human Hsp90 triggers binding to the cochaperone p23. Proceedings of the National Academy of Sciences of the United States of America. 108: 580-585, 2011.

9 Hausmann J*, Christodoulou E*, Kasiem M, De Marco V, van Meeteren LA, Moolenaar WH, Axford D, Owen RL, Evans G, and Perrakis A. Mammalian cell expression, purification, crystallization and microcrystal data collection of autotaxin/ENPP2, a secreted mammalian glycoprotein. Acta Crystallographica Section F 66: 1130-1135, 2010.

Day JE, Hall T, Pegg LE, Benson TE, Hausmann J, and Kamtekar S. Crystallization and preliminary X-ray diffraction analysis of rat autotaxin. Acta Crystallographica Section F 66: 1127-1129, 2010.

Cremers CM, Reichmann D, Hausmann J, Ilbert M, and Jakob U. Unfolding of metastable linker region is at the core of Hsp33 activation as a redox-regulated chaperone. The Journal of Biological Chemistry 285: 11243-11251, 2010.

* These authors contributed equally to the work

§ Shared corresponding authors

(Changed: 01 Nov 2022)