Cyber-Physical Systems (CPS) represent one of the most prominent trends in computer technology, creating a deep integration of hardware and software components. They have evolved in conjunction with Internet of Things (IoT) and various smart approaches, in manufacturing, transportation, health care, buildings, emergency response. As the world has become increasingly inter-related - due to services, mobile devices, Cloud Computing, and wireless networks - CPS have highly proliferated, facing challenges like scalability, composability, and heterogeneity. The aim is to elaborate integrated models that drive cyber-physical systems, and specific modeling languages, for dealing with the level of complexity required in real-world settings.