The expansion of the sustainable use of the oceans as part of the "Blue Growth Strategy" and the expected increase in marine natural hazards as a result of climate change, such as harmful microorganisms or hypoxia, means that marine biological hazards and their prevention will also be of growing socio-economic importance for German coastal waters in the future. There is currently no jointly coordinated strategy by the coastal states in Germany to meet this social challenge. PrimePrevention aims to create knowledge and technical conditions for the efficient monitoring and prediction of the occurrence of marine biological hazards in order to derive recommendations for measures to protect society from their economic and health impacts, also taking into account cascading effects from other marine extremes. PrimePrevention focuses on developing an intelligent and flexible marine monitoring strategy that can be tailored to the monitoring needs of individual stakeholders.