PhD position at University of Oldenburg, Division of experimental Allergy and Immunodermatology, in Cooperation with the Divison of Anatomy, Germany, starting on the 01.11.2019
(TV-L E13, 65 % for three years) (m/f/d)
as part of the PhD project "Role of lipid mediators in regulating human granulocyte function associated with neuronal pruritic responses in bullous pemphigoid" as a cooperation project between the division of experimental Allergy and Immunodermatology, Prof. Dr. Ulrike Raap and apl. Prof. Dr. Bernhard Gibbs, as well as the division of Anatomy, Prof. Dr. Anja Bräuer).
Chronic pruritus ("itching") is an important clinical symptom in a variety of diseases, which can significantly reduce quality of life and is particularly difficult to treat (e.g., in the autoimmune disease bullous pemphigoid). Increasing evidence suggests that lipid mediators such as lysophosphatidic acid (LPA) regulate itch. Since pruritus plays a major role in bullous pemphigoid we hypothesize that lipid mediators crucially govern the symptoms associated with this autoimmune disease. Basophils and eosinophils are dynamically recruited to the skin in bullous pemphigoid and are known to be major sources of pruritic mediators. Your aims are therefore to address whether LPA and other lipid mediators affect the activation and pro-pruritic responses of these granulocytes.
An academic university degree (MSc or equivalent) in life science, biology, biochemistry, medicine or equivalent is required together with a good knowledge of German and English (both spoken and written skills). Animal and/or human experimental research experience is also desirable, but not mandatory. The basic readiness for animal experimental work is expected to successfully fulfill the task. An animal test certificate (FELASA-B) is also desirable. Hands-on experience in molecular biology, cell biology and biochemical methods is expected. Hands-on experience in one or more of the following techniques would be an advantage: FACS, quantitative PCR, immunological methods (Western Blot, ELISA, antibody staining), fluorescence microscopy, immunomagnetic cell isolation, chemotaxis assays.
The University of Oldenburg is dedicated to increasing the percentage of female employees in the field of science and encourages applications from female candidates. According to § 21, 3 NHG female applicants are preferentially considered in case of equal qualification.
Applicants with disabilities will be given preference provided they are equally qualified.
We look forward to receiving your complete application by 20.10.2019 (preferably by e-mail as a single PDF file) to the secretary of Prof. Ulrike Raap, Mrs. Silvia Ellinghaus.
Carl von Ossietzky Universität Oldenburg
Department für Humanmedizin, Fakultät VI
Abteilung für experimentelle Allergologie und Immundermatologie, W16
Univ.-Prof. Dr. Ulrike Raap
z. Hd. Silvia Ellinghaus (Forschungssekretariat)
Carl-von-Ossietzky-Straße 9 - 11
Tel.: ++49 (0)441 798 3734