Clinical research
Clinical research
Forschungsschwerpunkte
- Clinical research in coronary surgery, valve surgery, aortic surgery, heart failure and quality management
- Conducting observational and comparative studies to evaluate surgical treatment procedures
- Care research for the transition between treatment sectors and pre/postoperative monitoring
- Teaching research to improve surgical skills and analyse cardiovascular images
MANTRA
Study content:
Prospective, multicentre, global clinical post-marketing surveillance study. The main objective is to monitor the safety and performance of the commercially available LivaNova products used to treat aortic valve disease in clinical practice.
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IMPACT Register
Study content:
Non-interventional, prospective, open, multicentre, international registry with a follow-up period of 5 years, including patients undergoing surgical aortic valve replacement with the Edwards aortic valve INSPIRIS RESILIA™.
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ELIFIS
Study content:
ELIFIS study - Early and late infections after implant surgery: Cross-border comparison DE-NL.
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Precovery
Study content:
Prehabilitation "Karl-Heinz" with focus on cardiac and cognitive functions before cardiac interventions: a health status analysis - implementation and long-term (1 year) evaluation of a prehabilitation after cardiac intervention in elderly people (> 75 years) positively evaluated from many studies in the short term for 1.) improvement of health status, 2.) improvement of daily function, quality of life, physical and mental performance; level of care and mobility and 3.) reduction of associated health costs for SHI and hospital providers compared to the control group.
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DefiPace
Study design: Prospective, multicentre international study with two phases in consecutively admitted patients undergoing elective cardiac surgery.
Study objective: Safety and efficacy of low-energy electrical cardioversion with or without subsequent bi-atrial pacing in patients with post-operative atrial fibrillation in everyday clinical practice.
- Phase A: Approx. 150 consecutively admitted patients undergoing elective cardiac surgery (bypass or valve surgery).
- Phase B: Approx. 300 consecutively admitted patients undergoing elective cardiac surgery (bypass or valve surgery) with planned TMA implantation.
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PaCeS
Study content:
A prospective, multicentre, open-label, randomised study comparing OAC (oral anticoagulation) with no OAC (1:1 ratio) in patients who develop new-onset atrial fibrillation after coronary artery bypass graft surgery.
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CABG Registry/Customs
Prospective registry for patients with WDC (wearable cardioverter defibrillator) after coronary bypass surgery.
The aim of the study is to document the recovery of ventricular function (EF>35%) during the use of a WDC in patients with ischaemic heart failure after a first coronary bypass surgery under guideline-compliant medical therapy, and to collect and analyse data on quality of life, health care and mortality.
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ImCarS Register
Cardiac surgery registry and study platform (ImCarS) for patients with circulatory replacement therapy and surgical cardiac decompression.
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SAFRAN(sub-project of the BMBF project INGVER)
Ensuring treatment success after hospitalisation. The main aim of the study is to investigate how the everyday activities of elderly patients develop during and after hospitalisation. If a relative is involved in providing support at home, we would also like to offer them the opportunity to take part in the study. The findings will be used to develop long-term concepts for improving the care situation. Patients undergoing cardiac surgery are part of the SAFRAN project alongside other specialist disciplines.
SAFRAN is being carried out as part of an overarching project to research the intersectoral care of vulnerable groups (INGVER).
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Profile initiative geriatric medicine
Study content:
Profile initiatives are intended to lay the foundation for university medical centres. By bringing together various activities and players, they strengthen the self-image for the further development of university healthcare in conjunction with a joint (translational) research profile. This generates added value in both areas. Profile initiatives also aim to achieve better integration of patients in research work and clinical studies, for example by establishing the necessary data infrastructures.
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National quality assurance for AHF treatment
Study content:
The aim is to establish a mandatory national quality assurance system based on centralised data collection and evaluation of all cardiac surgery and catheter interventional procedures for congenital heart defects.
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German Aortic Valve Registry
Study content:
The registry is the joint responsibility of the German Society for Thoracic and Cardiovascular Surgery (DGTHG) and the German Society of Cardiology - Cardiovascular Research (DGK). For interventions in which diseased aortic valves have to be replaced, standardised data on the course of treatment is collected by the hospitals with the patient's consent and transmitted to the registry. Patients are also questioned about the treatment outcome at certain points after the operation.
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GERAADA
Study content:
Follow-up of the GERAADA (German Registry for Acute Type A Dissection of the Aorta) registry - Since the beginning of 2010, approx. 4,000 data sets of patients who have undergone surgery for acute type A dissection of the aorta have been collected from 50 German heart centres. The aim is not only to facilitate the answering of scientific questions, but also to map the care landscape in Germany longitudinally.
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