Leitung

Prof. Dr. Gerhard Hilt

Sekretariat

Gisela Kaulfuß

Institut für Chemie  (» Postanschrift)

W03 2-279 (» Adresse und Lageplan)

Mo - Fr. 10:00 - 11:30 Uhr und n. V.

+49 441 798-3716  (F&P

Forschung

Research in the Hilt Group

Organic Electrochemistry

These days, the main focus of our research is directed towards the applications of “unconventional” electrochemical methods in organic electro-synthesis.

  •             Paired electrolysis
  •             Cation-pool electrolysis
  •             Quasi-divided cell electrolysis
  •             200%-Cell electrolysis
  •             Alternating current electrolysis

A recent example from our group is the electrochemical version of the cis-chlorination of alkenes mediated by selenium compounds.

Boron- and Indium-Lewis Acid-Catalysed Transfer-Hydrogenations

The cobalt-catalysed Diels-Alder reaction allowed us to generate site-specific deuterated dihydroaromatic compounds. The transfer-hydrogenation initiated by Lewis acids, such as BF3 or InBr3 led to the regiospecific HD or DH transfer to alkenes.

Also, an InBr3-catalysed transfer-hydrogenation initiating a cyclisation towards furan derivatives could be realised.

Cobalt- and Nickel-catalysed Double Bond Isomerisation

Some time ago, we identified a cobalt catalyst for the isomerisation of terminal carbon-carbon double bonds of a 1,3-diene to yield 2Z,4E-configured dienes selectively. This reaction was applied for the synthesis of the (O-protected) allergic component of poison ivy.

Thereafter, a nickel-catalyst for the selective isomerisation of terminal alkenes to the corresponding Z-2-alkenes was identified. Also, this transformation was utilised in a natural product synthesis.

Further applications for these double bond isomerisation reactions are underway.

Cobalt-Catalysed Reactions

After two decades of research in the area of cobalt-catalysed transformations, we have left the field.

A Twenty-Year Survey in Low-Valent Cobalt-Catalyzed Transformations Comes to an End - A Farewell

DOI: 10.1055/s-0042-1753142

Quantification of Lewis Acids and Relation to Reactivities in Organic Transformations

The quantification of Lewis acidities was an interesting side field that we have left as well.

(Stand: 28.05.2024)  | 
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