Recovery from Acute Immune Failure in Septic Shock by Immune Cell Extracorporeal Therapy

In this project, patients with septic shock receive a special extracorporeal treatment with donor granulocytes to improve the immunological deficit during and after sepsis. The special feature here is that the study treatment does not treat the septic shock, but the medium-term negative effects on the immunological situation of the patients. Here at the centre, we have already included one patient in the study & treated him with immune cell therapy.

(Eudra-CT: 2020-003564-66)

Effect of high-dose vitamin D3 on 28-day mortality in adult critically ill patients with severe vitamin D deficiency: a multicentre, placebocontrolled double-blind phase III RCT

The aim of the study is to investigate the effect of high-dose vitamin D on 28-day mortality in critically ill patients with severe vitamin D deficiency (25(OH)D ≤ 12ng/ml). At the same time, it is being investigated whether high-dose vitamin D3 can reduce the length of hospitalisation, typical organ failure and infection rates, among other things.

(EudraCT-No.: 2016-002460-13)

Tranexamic acid for reduction of intra- and postoperative transfusion requirements in elective abdominal surgery: randomised controlled trial

The primary aim of this study is to assess whether the intraoperative administration of tranexamic acid reduces bleeding and thus the need for intraoperative and postoperative transfusion of red blood cell concentrate in major abdominal surgery.

In co-operation with the University Department of Visceral Surgery, Prof. M. Bockhorn.

(EudraCT No: 2023-509970-43-00)

Trombelastrometry in neurosurgical patients

The main objective of this study is to establish modified thrombelastography (TEG), in particular the low-dose TPA test, as a prognostic tool for predicting thromboembolic events in high-risk patients, especially those with intracranial tumours.

In co-operation with the EV. Hospital, Neurosurgery, Prof. J. Woitzek