The Endothelium, Inflammation and Haemostasis research group deals with central mechanisms of vascular and coagulation biology under physiological and pathophysiological conditions. The focus is on the question of how different stressors influence fundamental functions of the endothelium and haemostasis and what significance these changes have, particularly for vulnerable patient groups.

A particular research focus is on the study of neonatal and intensive care patients. Here we analyse age- and disease-specific characteristics of haemostasis as well as dynamic changes that can occur in the course of critical illnesses. The aim is to gain a better understanding of the processes that determine the stability or dysregulation of the coagulation system.

Methodologically, the working group combines basic research in molecular biology with modern experimental model systems. These include cell culture-based approaches and the use of flow chambers, which make it possible to investigate complex processes under the most physiological conditions possible. In addition, viscoelastic test procedures - in particular rotational thrombelastometry (ROTEM) - are used to map clinically relevant issues in a timely and patient-centred manner.

Our research pursues a translational approach that closely links experimental and clinical research. Through the targeted transfer of scientific findings from the laboratory to clinical application, we aim to develop safe and more effective treatment strategies and make a sustainable contribution to patient safety and care.