Prof. Dr. Karl-Wilhelm Koch

+49 (0)441 798-3640

W4 1-137 

2019 - 2020

Publikationen 2019

Peshenko, I.V., Cideciyan, A.V., Sumaroka, A., Olshevskaya, E.V., Scholten, A., Abbas, S., Koch, K.-W., Jacobson, S.G., Dizhoor, A.M. (2019) A G86R mutation in the calcium-sensor protein GCAP1 alters regulation of retinal guanylyl cyclase and causes dominant cone-rod degeneration. J. Biol. Chem. 294, 3476-3488.

Aqulia, M., Dell’Orco, D., Fries, R., Koch, K.-W. and Rispoli, G. (2019) Incorporating phototransduction proteins in zebrafish green cone with pressure-polished patch pipiettes. Biophys. Chem. 253, article 106230

Abbas, S., Marino, V., Dell'Orco, D., and Koch, K.-W. (2019) Molecular Recognition of Rhodopsin Kinase GRK1 and Recoverin Is Tuned by Switching Intra- and Intermolecular Electrostatic Interactions. Biochemistry 58, 4374-4385.

Koch, K.-W. and Christoffers, J. (2019) Mapping calcium-sensitive regions in GCAPs by site-directed fluorescence labelling. Methods Mol. Biol. 1929, 583-594.

Dell'Orco, D., Koch, K.-W., Kreutz, M.R., Naranjo, J.R., and Schwaller, B. (2019)  Neuronal Calcium Sensors in Health and Disease. Front. Mol. Neurosci. 12:278. (Editorial)


Abbas, S., Marino, V., Bielefeld, L., Koch, K.-W., and Dell'Orco, D. (2020) Constitutive Activation of Guanylate Cyclase by the G86R GCAP1 Variant Is Due to "Locking" Cation-π Interactions that Impair the Activator-to-Inhibitor Structural Transition. Int. J. Mol. Sci. 21 (3), 752.


Abbas, S., Marino, V., Weisschuh, N., Kieninger, S., Solaki, M., Dell'Orco, D., and Koch, K.-W. (2020) Neuronal Calcium Sensor GCAP1 Encoded by GUCA1A Exhibits Heterogeneous Functional Properties in Two Cases of Retinitis Pigmentosa. ACS Chem. Neurosci. 11(10), 1458-1470.

Wu, H., Scholten, A., Einwich, A., Mouritsen, H., and Koch, K.-W. (2020) Protein-protein Interaction of the Putative Magnetoreceptor Cryptochrome 4 Expressed in the Avian Retina. Sci. Rep. 10(1):7364.

Abbas, S. and Koch, K.-W. (2020) Quantitative determination of Ca2+-binding to Ca2+-sensor proteins by isothermal titration calorimetry. Bio-protocol 10(07):e3580.


(Stand: 21.08.2020)