I clamp the piece of wood in the vice. I clamp the workpiece with the clamping hands. I clamp the drill.
Medium
Clamp the wooden panel in the machine vice. Fix the workpiece to the wooden panel with the clamping hands Clamp the drill D=5 firmly in the drill chuck.
Heavy
Firstly, the wooden panel is clamped in the machine vice. Then the Plexiglas blank is fixed to the wooden panel with the clamping hand. Finally, the drill bit D=5 is clamped in the drill chuck.