Prof. Dr. Hans Gerd Nothwang 

+49 (0)441 798-2499


Carl von Ossietzky Universität Oldenburg
Fakultät VI - Department für Neurowissenschaften
Exzellenzcluster Hearing4all
Carl-von-Ossietzky-Str. 9-11 
26129 Oldenburg

Publikation 99-92

Publikationen 1992 bis 1999


Schröer A., Schneider S., Ropers H.H. and Nothwang H.G. (1999) Cloning and characterization of UXT, a novel gene in human Xp11, which is widely and abundantly expressed in tumor tissue. Genomics 56:340-343.

Wirth J., Nothwang H.G., Menzel C., Borck G., Lopez-Pajares I., Brondum-Nielsen K., Tommerup N., Bugge M., Ropers H.H. and Haaf T. (1999) Systematic characterization of disease-associated balanced chromosome rearrangements by FISH: cytogenetically and genetically anchored YACs identify microdeletions and candidate regions for mental retardation genes. J. Med. Genet. 36:271-278.

Nanda I., Shan Z.H., Schartl M., Burt D.W., Koehler M., Nothwang H.G., Grutzner F., Paton I.R., Windsor D., Dunn I., Engel W., Staeheli P., Mizuno S., Haaf T. and Schmid M. (1999) 300 million years of conserved synteny between chicken Z and human chromosome 9. Nature Genet. 21:258-259.

Caubit X., Thangarajah R., Theil T., Wirth J., Nothwang H.G., Ruther U. and Krauss S. (1999) Mouse dac, a novel nuclear factor with homology to Drosophila dachshund shows a dynamic expression in the neural crest, the eye, the neocortex, and the limb bud. Dev. Dynamics 214:66-80.


Nothwang H.G., Stubanus M., Adolphs J., Hanusch H., Vossmerbäumer U., Denich D., Kübler M., Mincheva A., Lichter P. and Hildebrandt F. (1998a) Construction of a gene map of the nephronophthisis type 1 (NPH1) region on human chromosome 2q12-q13. Genomics 47:276-285.

Nothwang H.G., Rensing C., Kübler M., Denich D., Brandl B., Stubanus M., Haaf T., Kurnit D. and Hildebrandt F.(1998b) Identification of a novel Ran binding protein 2 related gene (RanBP2L1) and detection of a gene cluster on human chromosome 2q11-q12. Genomics 47:383-392.

Hildebrandt F., Nothwang H.G., Vossmerbaumer U., Springer C., Strahm B., Hoppe B., Keuth B., Fuchshuber A., Querfeld U., Neuhaus T.J. and Brandis M. (1998) Lack of large, homozygous deletions of the Nephronophthisis 1 region in Joubert-Syndrome Type B. Pediat. Nephrol. 12:16-19.


Nothwang H.G., Strahm B., Denich D., Kübler M., Schwabe J., Gingrich J. C., Cox A., Nicklin M., Kurnit D.M. and Hildebrandt F. (1997a) Molecular cloning of the interleukin-1 gene cluster: construction of an integrated YAC, PAC and partial transcriptional map on chromosome 2q13. Genomics 41:370-378.

Nothwang H.G., Wirth J., Brandl B., Haaf T., Nielsen K.B., Tommerup N. and Ropers H.H. (1997b) Identification of positional candidates for neurological disorders on chromosome 13q14-q22. Cytogenet. Cell Genet. 79:293-297.

Hildebrandt F., Otto E., Rensing C., Nothwang H.G., Vollmer M., Adolphs J., Hanusch H. and Brandis, M. (1997a) A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1. Nature Genet 17:149-153.

Hildebrandt F., Strahm B., Nothwang H.G., Gretz N., Schnieders B., Singh-Sawhney I., Kutt R., Vollmer M., Brandis M., Bode U., Brodehl J., Latta K., Brouhard B., Dippel J., Feldhoff C., Wingen M., Filler G., Ghiggeri G.M., Guaywoodford L., Hoppe B., Klare B., Kuijten R.H., Kuhn K., Leumann E., Neumann H.P.H. et al. (1997b). Molecular genetic identification of families with juvenile nephronophthisis type 1 - rate of progression to renal failure. Kidney Internat. 51:261-269.


Hildebrandt F., Cybulla M., Strahm B., Nothwang H.G., Singh-Sawhney I., Berz K., Nicklin M., Reiner O. and Brandis M. (1996). Physical mapping of the gene for juvenile nephronophthisis (NPH1) by construction of a complete YAC contig of 7 Mb on chromosome 2q13. Cytogenet. Cell Genet. 73:235-239.


Coux, O. Nothwang, H.G. Silva-Pereira I., Recillas Targa F., Bey F. and Scherrer K. (1994) Phylogenic relationships of the amino acid sequences of prosome (proteasome, MCP) subunits. Mol. Gen. Genet. 245:769-780.

Nothwang H.G., Tamura T., Tanaka K. and Ichihara A. (1994) Sequence analyses and inter-species comparisons of three novel human proteasomal subunits, HsN3, HsC7-I and HsC10-II, confine potential proteolytic active-site residues. Biochim. Biophys. Acta 1219:361-368.

Tamura, T. Osaka, F. Kawamura Y., Higuti T., Ishida N., Nothwang H.G., Tsurumi C., Tanaka K. and Ichihara A. (1994) Isolation and characterisation of -Type HC3 and -type HC5 subunit genes of human proteasomes. J. Mol. Biol. 244:117-124.

Akiyama K.Y., Yokota K.Y. Kagawa S., Shimbara N., Tamura T., Akioka H., Nothwang H.G., Noda C., Tanaka K. and Ichihara A. (1994) cDNA cloning and interferon gamma-down-regulation of proteasomal subunits X and Y. Science 265:1231-1234.


Bey, F. Silva-Pereira I., Coux O., Viegas-Péquignot E., Recillas Targa F., Nothwang H.G., Dutrillaux B. and Scherrer K. (1993) The prosomal RNA-binding protein p27K is a member of the a-type human prosomal gene family. Mol. Gen. Genet. 237:193-205.


Nothwang H.G., Coux O., Bey F. and Scherrer K. (1992a) Prosomes and their multicatalytic proteinase activity. Eur. J. Biochem. 207:621-630.

Nothwang H.G. Coux O., Keith G., Silva-Pereira I. and Scherrer K. (1992b) The major RNA in prosomes of HeLa cells and duck erythroblasts is tRNALys,3. Nucleic Acids Res. 20:1959-1965.

Nothwang H.G., Coux O., Bey F. and Scherrer K. (1992c) Disruption of prosomes by some bivalent metal ions results in loss of their multicatalytic proteinase activity and cancels the nuclease resistance of prosomal RNA. Biochem. J. 287:733-739.

Coux O., Camoin L., Nothwang H.G., Bey, F. Silva-Pereira I., Keith G., Strosberg A.D. and Scherrer K. (1992a) The protein of Mr 21 000 constituting the prosome-like particle of duck erythroblasts is homologous to apoferritin. Eur. J. Biochem. 207:823-832.

Coux O., Nothwang H.G., Scherrer K., Bergsma-Schutter W., Arnberg A. C., Timmins P.A., Langowski J. and Cohen-Addad C.C. (1992b) Structure and RNA content of prosomes. FEBS Lett. 300:49-55.

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