Kontakt

Prof. Dr. Karl-Wilhelm Koch

+49 (0)441 798-3640

W4 1-137

Vor 2000

1. Original Paper

Kaupp, U.B. and Koch, K.-W. (1984) Cyclic GMP releases calcium from leakey rod outer segments. Vision Res. 24, 1477-1479

Koch, K.-W. and Kaupp, U.B. (1985) Cyclic GMP directly regulates a cation conductance in membranes of bovine rods by a cooperative mechanism. J. Biol. Chem. 260, 6788-6800

Cook, N.J., Zeilinger, C., Koch, K.-W. and Kaupp, U.B. (1986) Solubilization and functional reconstitution of the cGMP-dependent channel from bovine rod outer segments. J. Biol. Chem. 261, 17033-17039

Koch, K.-W. and Kaupp, U.B. (1987) Control of the light-regulated ion channel in vertebrate photoreceptors by cyclic GMP and l-cis-Diltiazem. Adv. Biosci. 62, 339-343

Koch, K.-W., Cook, N.J. and Kaupp, U.B. (1987) The cGMP-dependent channel of vertebrate rod photoreceptors exists in two forms of different cGMP sensitivity and pharmacological behaviour. J. Biol. Chem. 262, 14415-14421

Koch, K.-W. and Stryer, L. (1988) Highly cooperative feedback control of retinal rod guanylate cyclase by calcium ions. Nature 334, 64-66

Koch, K.-W., Eckstein, F. and Stryer, L. (1990) Stereochemical course of the reaction catalyzed by guanylate cyclase from bovine retinal rod outer segments. J. Biol. Chem. 265, 9659-9663

Koch, K.-W. (1991) Purification and identification of photoreceptor guanylate cyclase. J. Biol. Chem. 266, 8634-8637

Lambrecht, H.-G. and Koch, K.-W. (1991) A 26 kd calcium binding protein from bovine rod outer segments as modulator of photoreceptor guanylate cyclase. EMBO J. 10, 793-798

Lambrecht, H.-G. and Koch, K.-W. (1991) Phosphorylation of recoverin, the calcium-sensitive activator of photoreceptor guanylyl cyclase. FEBS Lett. 294, 207-209

Lambrecht, H.-G. and Koch, K.-W. (1992) Recoverin, a novel calcium-binding protein from vertebrate photoreceptors. Biochim. Biophys. Acta 1160, 63-66

Pongs, O., Lindemeier, J., Zhu, X.R., Theil, T., Engelkamp, D., Krah-Jentgens, I., Lambrecht, H.-G., Koch, K.-W., Schwemer, J., Rivosecchi, R., Mallart, A., Galceran, J., Canal, I., Barbas, J.A., and Ferrus, A. (1993) Frequenin- a novel calcium-binding protein that modulates synaptic efficacy in the Drosophila nervous system. Neuron 11, 15-28

Koch, K.-W., Stecher, P. and Kellner, R. (1994) Bovine retinal guanyl cyclase represents a new N-glycosylated subtype among the membrane bound guanylyl cyclases. Eur. J. Biochem. 222, 589-595

Koch, K.-W., Lambrecht, H.-G., Haberecht, M., Redburn, D. and Schmidt, H.H.H.W. (1994) Functional coupling of a Ca2+/calmodulin dependent nitric oxide synthase and a soluble guanylyl cyclase in vertebrate photoreceptor cells. EMBO J. 13, 3312-3320

Zoche, M. and Koch, K.-W. (1995) Purified retinal nitric oxide synthase enhances ADP-ribosylation of rod outer segment proteins. FEBS Lett. 357,178-182

Frins, S. Bönigk, W., Müller ,F. Kellner, R. and Koch, K.-W. (1996) Functional characterization of a guanylyl cyclase-activating protein from vertebrate rods - cloning, heterologous expression and localization. J. Biol. Chem. 271, 8022-8027

Zoche, M. Bienert, M., Beyermann, M. and Koch, K.-W. (1996) Distinct molecular recognition of calmodulin-binding sites in the neuronal and macrophage nitric oxide synthases: a surface plasmon resonance study. Biochemistry 35, 8742-8747

Zoche, M., Beyermann, M. and Koch, K.-W. (1997) Introduction of a Phosphate at Serine741 of the Calmodulin-Binding Domain of the Neuronal Nitric Oxide Synthase (NOS-I) Prevents Binding of Calmodulin. Biol. Chem. 378, 851-857

Lange, C. and Koch, K.-W. (1997) Calcium-Dependent Binding of Recoverin to Membranes Monitored by Surface Plasmon Resonance Spectroscopy in Real Time. Biochemistry 36, 12019-12026

Weitz, D., Zoche, M., Müller, F., Beyermann, M., Körschen, H.G., Kaupp, U.B. and Koch, K.-W. (1998) Calmodulin controls the Rod Photoreceptor CNG Channel through an Unconventional Binding Site in the N-Terminus of the b-Subunit. EMBO J. 17, 2273-2284

Duda, T., Venkataraman, V., Goraczniak, R.. Lange, C., Koch, K.-W. and Sharma, R. K. (1999) Functional Consequences of a Rod Outer Segment Membrane Guanylate Cyclase (ROS-GC1) Geene Mutation Linked with Leber´s Congenital Amaurosis. Biochemistry 38, 509-515

Schrem, A., Lange, C., Beyermann, M. and Koch, K.-W. (1999) Identification of a Domain in Guanylyl Cyclase-activating Protein 1 That Interacts with a Complex of Guanylyl Cyclase and Tubulin in Photoreceptors. J. Biol. Chem. 274, 6244-6249

Körschen, H. G., Beyermann, M., Müller, F., Heck, M., Vantler, M., Koch, K.-W., Kellner, R., Wolfrum, U., Bode, C., Hofmann, K. P. and Kaupp, U. B. (1999) Interaction of glutamic acid-rich proteins with components of the cGMP-signaling pathway in rod photoreceptors. Nature 400, 761-766

Duda, T., Krishnan A., Venkataraman, V., Lange, C., Koch, K.-W. and Sharma, R.K. (1999) Mutations in the Rod Outer Segment Membrane Guanylate Cyclase (ROS-GC1) in a Cone-Rod Dystrophy Cause Defects in Calcium Signaling. Biochemistry 38, 13912-13919

Lange, C., Duda, T., Beyermann, M. Sharma, R.K. and Koch, K.-W. (1999) Regions in vertebrate photoreceptor guanylyl cyclase ROS-GC1 involved in Ca2+-dependent regulation by guanyly cyclase-activating protein GCAP-1. FEBS Lett. 460, 27-31

  

2. Review Articles

Kaupp, U.B. and Koch, K.-W. (1986) Mechanism of photoreception in vertebrate vision. Trends Biochem. Sci. 11, 43-47

Kaupp, U.B. and Koch, K.-W. (1992) Role of cGMP and Ca2+ in vertebrate photoreceptor excitation and adaptation. Ann. Rev. Physiol. 54, 153-175

Koch, K.-W. (1992) Biochemical mechanism of light adaptation in vertebrate photoreceptors. Trends Biochem. Sci. 17, 307-311

Koch, K.-W. (1994) Calcium as modulator of phototransduction in vertebrate photoreceptor cells. Rev. Physiol. Biochem. Pharmacol. Vol. 125,149-192

Baumann, A., Frings, S. Koch, K.-W. and Weyand,I. (1995) Signal transduction in vision and the chemical senses. 71st International Titisee Conferences. Futura 3/95, 168-178

Koch, K.-W. (1995) Control of photoreceptor proteins by Ca2+. Cell Calcium 18, 314-321

Koch, K.-W. (1995) Crucial steps in photoreceptor adaptation: regulation of phosphodiesterase and guanylate cyclase activities and Ca2+-buffering. Behav. Brain Sci. 18 (3)

Müller, F. and Koch, K.-W. (1998) Calcium-binding proteins and nitric oxide in retinal function and disease. Acta Anat. 162, 142-150

3. Articles in Monographs, Books etc

Kaupp, U.B. and Koch, K.-W. (1986) Significance of changes in intracellular Ca2+ for the mechanism of signal transduction in vertebrate rod cells. In: The Molecular Mechanism of Photoreception, H. Stieve (ed.), pp. 93-107. Dahlem-Konferenzen 1986, Berlin, Heidelberg, New York, Toyko; Springer Verlag

Kaupp, U.B., Cook, N.J., Koch, K.-W. and Hanke, W. (1987) Electrical and biochemical properties of the cGMP-gated cation channel from rod photoreceptors. Discussion in Neuroscience FESN, Vol. IV, No. 3, 95-104

Koch, K.-W. and Lambrecht, H.-G. (1992) Photoreceptor guanylate cyclase and its regulation by calcium. in: Signal Transduction in Photoreceptor Cells (Hargrave, P.A., Hofmann, K.-P., Kaupp, U.B. eds.), Springer-Verlag, 259-267

Koch, K.-W. (1992) Recovery of the photoresponse in vertebrate photoreceptors: role of Ca2+ -dependent regulation of guanylate cyclase. Structures and Functions of Retinal Proteins. Vol.221, 391-394

Koch, K.-W. (1993) Biochemie des Sehvorgangs im Wirbeltierauge. Retinitis-Pigmentosa Forschung in Deutschland, Programme-Projekte-Perspektiven. Herausgegeben von der Deutschen Retinitis Pigmentosa-Vereinigung e.V. in Zusammenarbeit mit dem DFG-Schwerpunkt "Erbliche Netzhautdegeneration". p 44-46.

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