Research

Kontakt

Direktor

Universitätsklinik für Innere Medizin – Kardiologie

Prof. Dr. Albrecht Elsässer

Sekretariat im Klinikum Oldenburg

Cynthia Garmhausen

+49 (0)441 403-2424

+49 (0)441 403-2784 

Sekretariat Exp. Cardiology (Campus Wechloy)

Anne Rabow

+49 (0)441 798-3738

Postanschrift Campus Wechloy

Carl von Ossietzky Universität Oldenburg
Fakultät VI Medizin und Gesundheitswissenschaften
Department für Humanmedizin
Carl-von-Ossietzky-Straße 9-11
26129 Oldenburg

Besucheranschrift Campus Wechloy

Gebäude W4, 1. OG, Raum 206
Carl-von-Ossietzky-Straße 9-11
26129 Oldenburg

 

Zur Homepage vom Klinikum Oldenburg

Research

Project: Development of a biodegradable scaffold for coronary healing

Cardiovascular diseases are the leading cause of death worldwide for the last 2 decades, and the coronary artery disease (CAD) tops this list. Percutaneous coronary intervention (PCI) is a minimally invasive procedure in which a stent (small scaffold) is placed via catheter to open the blocked coronary arteries. It is a widely used therapy, but vessel healing after stenting remains a challenge worldwide due to restenosis, chronic inflammation, and thrombosis. According to the current guideline the stent can only be placed when the stenosis degree exceeds 70%. It means that most lesions, which do not limit flow, cannot be treated even though they represent a potential cause of rupture and thrombotic occlusion.
 

A fast and effective endothelization is a key factor for a successful vascular implant. Therefore, the final aim of this project is to produce a biodegradable preventive stent for nonculprit arteries, able to improve the vascular healing. To date, we obtained 3 polymer blends with great potential for vascular healing. They improve human coronary endothelial cell (HCAEC) adhesion, migration, and created a favorable microenvironment for the cells with anti-inflammatory properties, evaluated by molecular and functional assays (unpublished data).
 

A high-resolution hybrid 3D bioprinting has being used to create the biodegradable stent with the previously selected polymer blend (R-Gen-100 bioprinter by RegenHU). The materials are being currently tested in vitro using a 2D scaffold.
 

We are looking for students to actively join our team for research and master projects.
Please enquire if you are interested!

(Stand: 26.03.2024)  | 
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