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Prof. Dr. Anja U. Bräuer

+49 (0)441 798-3995

Postanschrift

Fakultät VI Medizin und Gesundheitswissenschaften
Carl von Ossietzky Universität Oldenburg
Carl-von-Ossietzky Str. 9-11
26129 Oldenburg

Lageplan

Direktorin

Prof. Dr. Anja U. Bräuer
Fachanatomin

+49 (0)441 798-3995

W34 0-008

https://www.researchgate.net/profile/Anja_Braeuer
https://www.linkedin.com/in/anja-u-br%C3%A4uer-16084313b/
                                         https://uol.de/neurosensorik/
                                         https://www.xing.com/profile/AnjaU_BraeuerProfDr/cv

Kurzbiographie

Derzeitige Position

seit 2019
Prodekanin für Forschung
seit 2017
Direktorin der Abteilung Anatomie im Department  Humanmedizin der Carl von Ossietzky Universität Oldenburg
Mitglied im Forschungszentrum Neurosensorik

Akademische Ausbildung und wissenschaftlicher Werdegang

2014 - 2017    
stellvertretende Direktorin im Institut für Anatomie und Leiterin der Arbeitsgruppe molekulare Neurobiologie an der Universitätsmedizin Rostock

2012 - 2014    
Leiterin der Arbeitsgruppe molekulare Neurobiologie an der Charité - Universitätsmedizin Berlin

Sep. 2014      
Verleihung der Bezeichnung „Fachanatomin der Anatomischen Gesellschaft

2009 - 2011    
kommissarische Leiterin des Institutes Zell- und Neurobiologie, Charité - Universitätsmedizin Berlin

2006 - 2012    
Juniorprofessorin für Molekulare Neurobiologie an der Charité - Universitätsmedizin Berlin

2004 - 2006    
Wissenschaftliche Assistentin am Institut für Zell- und Neurobiologie, Charité - Universitätsmedizin Berlin

2003 - 2004    
Research Fellow Institute of Biochemistry, University of Alberta, Edmonton, Kanada

2002 - 2003    
Wissenschaftliche Mitarbeiterin im Centrum für Anatomie, Charité - Universitätsmedizin Berlin

1997 - 2002    
Humboldt-Universität zu Berlin, Medizinische Fakultät Charité, Berlin

Promotionsthema: Regulation läsionsinduzierter Moleküle im Hippocampus der Ratte nach Deafferenzierung unter Verwendung molekularbiologischer Analyseverfahren

Bewertung: summa cum laude

Mitgliedschaften in wissenschaftlichen Fachgesellschaften

  • Neurowissenschaftliche Gesellschaft
  • Deutsche Anatomische Gesellschaft

Gutachtertätigkeiten für folgende Zeitschriften

  • Frontiers in Molecular Neuroscience
  • Cellular and Molecular Neurobiology
  • Cell and Tissue Research
  • BBA - Molecular and Cell Biology of Lipids
  • BBA - Molecular Basis of Disease
  • Cerebral Cortex
  • Annals of Anatomy
  • Aging - clinical and experimental research 

Publikationen

1. Gläser A, Hammerl F, Gräler MH, Coldewey SM, Völkner C, Frech MJ, Yang F, Luo J, Tönnies E, von Bohlen Und Halbach O, Brandt N, Heimes D, Neßlauer AM, Korenke GC, Owczarek-Lipska M, Neidhardt J, Rolfs A, Wree A, Witt M, Bräuer AU.  Identification of Brain-Specific Treatment Effects in NPC1 Disease by Focusing on Cellular and Molecular Changes of Sphingosine-1-Phosphate Metabolism. Int J Mol Sci. 2020 Jun 24;21(12):E4502. doi: 10.3390/ijms21124502.

2. Janach GMS, Reetz O, Döhne N, Stadler K, Grosser S, Byvaltcev E, Bräuer AU, Strauss U. Interferon-γ acutely augments inhibition of neocortical layer 5 pyramidal neurons. J Neuroinflammation. 2020 Feb 22;17(1):69. doi: 10.1186/s12974-020-1722-y.

3. Seemann S, Ernst M, Cimmaruta C, Struckmann S, Cozma C, Koczan D, Knospe AM, Haake LR, Citro V, Bräuer AU, Andreotti G, Cubellis MV, Fuellen G, Hermann A, Giese AK, Rolfs A, Lukas J. Proteostasis regulators modulate proteasomal activity and gene expression to attenuate multiple phenotypes in Fabry disease. Biochem J. 2020 Jan 3

4. Brand I., Groß I., Li D., Zhang Y., Bräuer AU. Pneumatic conveying printing technique for bioprinting applications. RSCAdv., 2019, 9, 40910: DOI: 10.1039/c9ra07521f

5. Feng X, Yang F, Rabenstein M, Wang Z, Frech M, Wree A, Bräuer AU, Witt M., Gläser A., Hermann A., Rolfs A, Luo J, Stimulation of mGluR1/5 improves defective internalization of AMPA receptors in NPC1 mutant mouse, Cerebral Cortex, 2019, Oct 10

6. Gross I., Bräuer AU., Modulation of LPA Receptor Activity: the key to successful neural regeneration? Neural Regen Res, 2020 15(1):53-54

7. Breuel S., Vorm M., Bräuer AU., Owczarek-Lipska M., Neidhardt J. Combining engineered U1 snRNA and antisense oligonucleotides to improve the treatment of a BBS1 splice site mutation, Molecular Therapy - Nucleic Acids, 2019 Aug 16; 18:123-130

8. Bräuer AU, Kuhla A, Holzmann C, Wree A, Witt M. Current Challenges in Understanding the Cellular and Molecular Mechanisms in Niemann-Pick Disease Type C1. Int J Mol Sci., 2019 Sep, 6;20(18)

9. Neßlauer A-M., Gläser A., Gräler M., Engelmann R., Müller-Hilke B., Frank M., Burstein C., Rolfs A., Wree A., Witt M., Bräuer AU. A therapy with miglustat, 2-hydroxypropyl-ß-cyclodextrin and allopregnanolone restores splenic cholesterol homeostasis in Niemann-Pick Disease Type C1. Lipids Health Dis., 2019 June, 18:146

10. Suckau O.*, Gross I.*, Schrötter S., Yang F., Luo J., Wree A., Chun J., Baska D., Baumgart J., Kano K., Aoki J., Bräuer AU. LPA1, LPA2, LPA4, and LPA6 receptor expression during mouse brain development. Developmental Dynamics, 2019 Mar 8

11. Meyer A,*, Gläser A.*, Bräuer AU., Wree A., Strotmann J., Rolfs A., Witt M. Olfactory performance as an indicator for protective treatment effects in an animal model of neurodegeneration, Front. Integr. Neurosci. 2018 Aug. 12;12:35

12. Ebner L., Gläser A., Bräuer AU., Witt M., Wree A., Rolfs A., Frank M., Vollmar B., Kuhla A.Evaluation of Two Liver Treatment Strategies in a Mouse Model of Niemann-Pick-Disease Type C1.,Int. J. Mol. Sci. 2018, 19, 972

13. Lukas J., Cozma C., Yang F., Kramp G., Meyer A., Eichler S., Neßlauer AM., Böttcher T., Witt M.,Bräuer AU., Kropp P., Rolfs A. Glucosylsphingosine Causes Hematological and Visceral Changes in Mice—Evidence for a Pathophysiological Role in Gaucher Disease, Int. J. Mol. Sci. 2017, Oct 20; 18(10)

14. Neubert J. and Bräuer AU., Superparamagnetic iron oxide nanoparticles: promote neuronal regenerative capacity, Neural Regen Res., 2015 Oct;(10)10:1568-9

15. Klar M., Fenske P., Rezza Vega F., Dame C.*, Bräuer AU.* The transcription factor Yin-Yang 2 alters neuronal outgrowth in vitro, Cell Tissue Res., 2015 Nov;362(2):453-60

16. Pohland M.*, Glumm R.*, Stoenica L., Höltje M., Kiwit J., Ahnert-Hilger G., Strauss U., Bräuer AU., Paul F., Glumm J. Studying axonal outgrowth and regeneration of the corticospinal tract in organotypic slice cultures, J. Neurotrauma, 2015, 7:14

17. Neubert J., Wagner S., Kiwit J., Bräuer AU.*, Glumm J.*. Effects of different superparamagnetic iron oxide nanoparticles on murine primary brain cells. International Journal of Nanomedicine, 2015, 10, 2033-2049

18. Coiro P., Stoenica L., Strauss U., Bräuer AU. Plasticity-related gene 5 expression promotes spine formation in primary neurons. J Biol Chem, 2014, July 29

19. Hübner A., Derkow K., Bräuer AU. Efficient isolation of CD8a positive T cells from postnatal mice using a combined MACS approach. J Immunol Methods, 2014  Apr:406: 110 116

20. Rupprecht A., Sittner D., Smorodchenko A., Hilse K., Goyn J., Moldzio R., Seiler A., Bräuer AU., Pohl EE. Uncoupling protein 2 and 4 expression pattern during stem cell differentiation provides new insight in their putative function. PLOS One, 2014 Feb. 11; 9 (2): e88474

21. Velmans T., Battefeld A., Geist B., Soriguera Farrés A., Strauss U., Bräuer AU. Plasticity related gene-3 promotes neurite shaft protrusion. BMC Neuroscience, 2013 Mar 19;14:36

22. Rupprecht A., Bräuer AU., Smorodchenko A., Goyn J., Hilse KE., Shabalina IG., Infante-Duarte C., and Pohl EE. Quantification of uncoupling protein 2 reveals its main expression in immune cells and selective up-regulation upon T-cell proliferation. PLOS One, 2012;7(8):e41406

23. Stadler K., Bierwirth C., Stoenica L., Battefeld A., Reetz O., Mix E., Schuchmann S., Velmans T., Rosenberger K., Bräuer AU., Lehnardt S., Nitsch R., Budt M., Wolff T., Kole MH., Strauss U., Elevation in type I interferons inhibits HCN1 and slows cortical neuronal oscillations. Cerebral Cortex, 2012 Oct 4

24. Battefeld A., Rocha N., Stadler K., Bräuer AU., and Strauss U., Distinct Perinatal Features of the Hyperpolarization-Activated Non-Selective cation current Ih in the rat cortical plate. Neural Development, 2012 Jun 13; 7(1):21

25. Vogt J., Glumm R., Schlüter L., Schmitz D., Rost BR., Streu N., Rister B., Suman Bharathi B., Gagiannis D., Hildebrandt H., Weinhold B., Mühlenhoff M., Naumann T., Savaskan NE., Bräuer AU., Reutter W., Heimrich B.*, Nitsch R.* and Horstkorte R*. Homeostatic regulation of NCAM polysialylation is critical for correct synaptic targeting, Cell Mol Life Sci, 2012 Apr;69(7):1179-91

26. Braun D., Kinne A., Bräuer AU., Sapin R., Klein MO., Köhrle J., Wirth EK.*, Schweizer U.*, Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells, Glia, 2011 Mar;59(3):463-71

27.  Wierschke S., Gigout S., Horn P. Lehmann TN., Dehnicke C., Bräuer AU.* and Deisz RA.*, Evaluating reference genes to normalize gene expression in human epileptogenic brain tissues, Biochem. Bioph Res Co., 2010 Dec 17;403(3-4):385-390

28.  Kühbacher M., Bartel J., Hoppe B., Alber D., Bukalis G., Bräuer AU., Behne D., Kyriakopoulos A. The brain selenoproteome: Priorities in the hierarchy and different levels of selenium homeostasis in the brain of selenium deficient rats, J Neurochem., 2009 Apr 21

29. Trimbuch T.*, Beed P.*, Vogt J.*, Schuchmann S., Maier N., Kintscher M., Breustedt J., Schuelke M., Streu N., Kieselmann O., Brunk I., Laube G., Strauss U., Battefeld A., Wende H., Birchmeier C., Wiese S., Sendtner M., Kawabe H., Kishimoto-Suga M., Brose N., Baumgart J., Geist B., Aoki J., Savaskan NE., Bräuer AU., Chun J., Ninnemann O., Schmitz D.*, Nitsch R.* Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling, Cell, 2009 Sep 18, 138 (6):1222-35

30. Wirth EK*, Roth S*, Blechschmidt C, Hölter S, Becker L, Racz I, Durner VG, Fuchs H, Naumann T, Bräuer AU, Köhrle J, Grüters A, Schweizer U. Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome, J. Neurosci., 2009 Jul. 29; 29(30):9439-49

31. Smorodchenko A.*, Rupprecht A.*, Sarilova I., Ninnemann O., Bräuer AU., Franke K., Schumacher S., Techritz S., Nitsch R., Schuelke M., Pohl EE. HHComparative analysis of uncoupling protein 4 distribution in various tissues under physiological conditions and during developmentHH, BBA-Biomembranes, 2009 Oct; 17888(10):2309-19

32. Drews D., Klar M., Dame C*, Bräuer AU.*, Developmental expression profile of the yy2 gene in mice, BMC Dev Biol. 2009 Jul 28; 9:45

33. Hoppe B.*, Bräuer AU.*, Kühbacher M., Savaskan NE., Behne D. and Kyriakopoulos A. Biochemical analysis of the selenoprotein expression in brain cell lines and in distinct brain regions Cell Tissue Res, 2008 Jun. 332(3): 403-414

34. Nürnberg A., Bräuer AU., Wettschureck N., and Offermanns S. Antagonistic regulation of neurite morphology through Gq/g11 and G12/G13, J Biol Chem, 2008 Dec. 19; 283 (51): 35526-35531

35. Kole MH, Bräuer AU, and Stuart GJ. Inherited cortical HCN1 channel loss amplifies dendritic calcium electrogenesis and burst firing in a rat absence epilepsy model J. Physiol., Jan., 15, 578 (Pt 2): 507-525, 2007

36. Savaskan NE, Rocha L, Kotter MR, Baer A, Lubec G, van Meeteren LA, Kishi Y, Aoki J, Moolenaar WN, Nitsch R, and Bräuer AU. Autotaxin (NPP-2) in the brain: cell type-specific expression and regulation during development and after neurotrauma. Cell Mol Life Sci, Jan, 64(2): 230-243, 2007

37. Savaskan NE, Borchert A, Bräuer AU and Kühn H. A role for glutathione peroxidase-4 in brain development and neuronal apoptosis. Free Radical Bio Med, Jul. 15; 43(2): 191-201, 2007

38. Dalla Puppa L., Savaskan NE., Bräuer AU, Behne D. and Kyriakopoulos A. The role of selenite on microglia migration. Ann NY Acad. Sci., Jan 1096: 179-183, 2007

39. Schridde U*, Strauss U*, Bräuer AU*, and van Luijtelaar G. Environmental manipulations early in development alter seizure activity, Ih and HCN1 protein expression later in life. Eur J Neurosci., 23(12):3346-3358, 2006

40. Peeva GP*, Angelova SK*, Guntinas-Lichius O, Streppel M, Irintchev A*, Schütz U, Popratiloff A, Savaskan NE, Bräuer AU, Alvanou A, Nitsch R, and Angelov DN*. Improved outcome of facial nerve repair in rats is associated with enhanced regenerative response of motoneurons and augmented neocortical plasticity. Eur J Neurosci., 24 (8): 2152-2162, 2006

41. Schäfer M., Bräuer AU, Savaskan NE, Rathjen FG, and Brümmendorf T. Neurotractin/Kilon promotes neurite outgrowth and is expressed on reactive astrocytes after entorhinal cortex lesion. Mol Cell Neurosci., 29(4):580-90, 2005

42. Bajorat R, Bräuer AU, Wasner U, Rolfs A, and Strauss U. Functional significance of HCN2/3 mediated Ih in striatal cells at early developmental states. J Neurosci. Res. 82 (2):206-13, 2005

43. Strauss, U.*, Kole MH.*, Bräuer AU., Pahnke J., Bajorat R., Rolfs, A., Nitsch R., and Deisz RA. An impaired neocortical Ih is associated with enhanced excitability and epilepsy. Eur J Neurosci. Jun;19(11):3048-58, 2004

44. Bräuer, AU., Nitsch R. and Savaskan NE. Identification of macrophage/ microglia activation factor (MAF) associated with late endosomes/lysosomes in microglial cells. FEBS Lett., 9;563(1-3):41-8, 2004

45. Meier, S., Bräuer, AU., Heimrich, B., Nitsch, R. and Savaskan, NE. Myelination in the hippocampus during development and following lesion. Cell Mol Life Sci, 61(9):1082-94, 2004

46. Savaskan, NE*, Bräuer, AU*, and Nitsch, R. Molecular cloning and expression regulation of PRG-3, a new member of the plasticity-related gene family. Eur J Neurosci., 19(1):212-20, 2004

47. Bräuer AU.*, Savaskan NE.*, Kühn H., Prehn S., Ninnemann O., and Nitsch R. Is PRG1 a new lipid phosphatase? Nat Neurosci Comment, 7 (8), 2004

48. Bräuer, AU., Savaskan, NE., Plaschke, M, Ninnemann, O. and Nitsch, R. The role of CCK in the course of de- and regeneration after lesion in the hippocampus: molecular evidence revealed by differential display-RT-PCR. Neuroscience;121(1):111-21, 2003

49. Bräuer AU.*, Savaskan NE.*, Kühn H., Prehn S., Ninnemann O., and Nitsch R. A new phospholipid phosphatase, PRG-1 is involved in axonal growth and regenerative sprouting. Nat Neurosci., 6(6):572-8, 2003

50. Eyüpoglu, IY.*, Savaskan, NE.*, Bräuer, AU.*, Nitsch, R. and Heimrich, B. Identification of neuronal cell death in a model of degeneration in the hippocampus. Brain Res Brain Res Protoc, 11(1):1-8, 2003

51. Savaskan, NE.*, Bräuer, AU.*, Kühbacher, M., Eyüpoglu, IY., Kyriakopoulos, A., Ninnemann, O., Behne, D. and Nitsch, R. Selenium dificiency increases susceptibility for glutamate-unduced excititoxicity. FASEB J, 17(1):112-4, 2003

52. Meier, S., Bräuer, AU., Heimrich B., Schwab, M., Nitsch, R. and Savaskan, NE. Molecular analyses of Nogo genes in the hippocampus during development and following lesion. FASEB J, 17(9):1153-5, 2003

53. Bräuer, AU.*, Savaskan, NE.*, Plaschke, M., Ninnemann, O. and Nitsch, R. Perforant path lesion induces up-regulation of stathmin mRNA, but not SCG10 mRNA, in the adult rat hippocampus. Neuroscience; 102 (3): 515-11126, 2001

54. Bräuer, AU.*, Savaskan, M.*, Kole, MHP.*, Plaschke, M., Monteggia, L., Nestler, E., Simbürger, E., Deisz, R., Ninnemann, O. and Nitsch, R. Molecular and functional analysis of hyperpolarization-activated pacemaker channels in the hippocampus after entorhinal cortex lesion. FASEB J; 15: 2689-2701, 2001

55. Savaskan, NE.*, Eyüpoglu, IY*, Bräuer, AU.*, Plaschke, M., Ninnemann, O., Nitsch, R. and Skutella T. Entorhinal cortex lesion studied with the novel dye fluoro-jade. Brain Res. May 2; 864(1): 44-51, 2000

56. Bräuer, AU.*, Savaskan, NE.*, Plaschke, M., Prehn, S., Ninnemann, O. and Nitsch, R. IG-molecule Kilon shows differential expression pattern from LAMP in the developing and adult rat hippocampus. Hippocampus 10(6): 632-44, 2000

57. Savaskan, NE.*, Skutella, T.*, Bräuer, AU., Plaschke, M., Ninnemann, O. and Nitsch, R. Outgrowth-promoting molecules in the adult hippocampus after perforant path lesion. Eur J Neurosci. Mar; 12(3): 1024-32, 2000

 

Reviews

1. Strauss U. and Bräuer AU. Current views on regulation and function of plasticity-related genes (PRGs/LPPRs) in the brain. BBA – Molecular and Cell Biology of Lipids. Special Issue: Lysophospholipids, Biochim Biophys Acta., 2013 Jan;1831(1):133-8

2. Bräuer AU and Nitsch R. Plasticity-related genes (PRGs/LRPs): A brain-specific class of lysophospholipid-modifying proteins. BBA – Molecular and Cell Biology of Lipids. Special Issue: Lysophospholipids, Biochim Biophys Acta., 2008 Sep;1781(9):595-600

3. Bräuer AU. and Savaskan NE. Molecular actions of selenium in the brain: neuroprotective mechanisms of an essential trace element. Rev Neuroscience; 2004 15(1):19-32

4. Schweizer, U., Bräuer AU., Köhrle J., Nitsch R., and Savaskan NE. Selenium and brain function: a poorly recognized liaison. Brain Res Brain Res Rev., 2004 Jul;45(3):164-78

 
*Contributed equally as first or senior author.

 

Books

1. D.N. Brindley and A.U. Bräuer
Chapter 12 Lipid Mediators and Modulators of Neuronal Function: Lysophosphatidate and Lysolipids Handbook of Neurochemistry and Molecular Neurobiology,
Neural Lipids, 2010, Part 3, 289-310, DOI: 10.1007/978-0-387-30378-9_12,
A. Lajtha, G. Tettamanti, & G. Goracci (eds.)

 

Patents 

1. Inventor(s): BERGHOF, Kornelia; GASCH, Alexander; BRÄUER, Anja; GRÖNEWALD, Cordt: WILBORN, Freimut; ROLFS, Arndt Applicant(s): BioteCon Gesellschaft für biotechnologische Entwicklung und Consulting mbH, Tegeler Weg 33, D-10589 Berlin, Deutschland
Titel: Amino acid sequences and method for isolating bacteries from the type genus Pseudomonas
Application Number:WO9912949A2  

2. Inventor(s): NITSCH, Robert; NINNEMANN, Olaf; BRÄUER, Anja; SAVASKAN, Nicolai Applicant(s): Humboldt-Universität zu Berlin, vertreten durch den Verwaltungsdirektor des Universitätsklinikums Charite, Berlin, Deutschland
Titel: Plasticity related Gene (PRG): Eine neue Klasse nervenspezifischer Membranproteine mit wachstumsregulierenden Eigenschaften.
Application Number: CH060/2002

3. Patentanmeldung läuft: Inventor(s): BRÄUER Anja und STRAUSS Ulf Applicant(s): Humboldt-Universität zu Berlin, vertreten durch den Verwaltungsdirektor des Universitätsklinikums Charite, Berlin, Deutschland
Titel: Verfahren zur Analyse eines Phospholipidprofils im Liquor als diagnostisches Verfahren für neurologische Erkrankungen
Application Number: CH580/2011

Sekretariat

Silvia Ellinghaus

+49 (0)441 798-3797

W34-0-007

Mi u. Do: 8.00 - 12.00 Uhr

Wissenschaftliche Mitarbeiter

Dr. med. Veysel Ödemis

+49 (0)441 798 2599

W34-0-009

Kurzbiographie

Derzeitige Position

seit 2017
wissenschaftlicher Mitarbeiter der Abteilung Anatomie im Department Humanmedizin der Carl von Ossietzky Universität Oldenburg

Akademische Ausbildung und wissenschaftlicher Werdegang

seit 2017       
Wissenschaftlicher Mitarbeiter in der Abteilung Anatomie im Department Humanmedizin der Carl-von-Ossietzky Universität Oldenburg

2012 - 2017   
Wissenschaftlicher Mitarbeiter für die Lehrkoordination der Anatomie an der Fakultät für Medizin und Gesundheitswissenschaften der Carl von Ossietzky Universität Oldenburg

Dez. 2010      
Erlangung des Facharztes für Anatomie

2001 - 2012   
Wissenschaftlicher Mitarbeiter am Institut für Anatomie der Universität Leipzig

2001              
Promotion mit dem Thema: „Die Veränderungen des Sauerstoffpartialdrucks im M. tibialis anterior des Menschen vor, während und nach tourniquetinduzierter Ischämie“

Bewertung: magna cum laude

1998 - 2001   
Wissenschaftlicher Mitarbeiter in der Abteilung Anatomie und Zellbiologie der Universität Ulm

1999              
Approbation zum Arzt

1997 - 1998   
Arzt im Praktikum in der Abteilung Allgemeinchirurgie an der Universitätsklinik Regensburg

1989 - 1996   
Medizinstudium an der Universität Ulm und Regensburg

Mitgliedschaften in wissenschaftlichen Fachgesellschaften

  • Neurowissenschaftliche Gesellschaft
  • Deutsche Anatomische Gesellschaft

Publikationen

1.Yahya I, Boeing M, Pu Q, Puchert M, Ödemis V, Engele J, Brand-Saberi B, Morosan-Puopolo G. CXCR4 and SDF-1 are critically involved in the formation of facial and non-somitic neck muscles. Scientific reports. 2020 10(1): 1-14.

2. Masyuk M, Abduelmula A, Morosan-Puopolo G, Ödemis V, Rehimi R, Khalida N, Yusuf F, Engele J, Tamamura H, Theiss C, Brand-Saberi B.: Retrograde migration of pectoral girdle muscle precursors depends on CXCR4/SDF-1 signaling. Histochem Cell Biol. 2014;142(5):473-88

3. Lipfert J., Ödemis V., Wagner DC., Boltze J., Engele J.: CXCR4 and CXCR7 form a functional receptor unit for SDF-1/CXCL12 in primary rodent microglia. Neuropathol Appl Neurobiol. 2013; 39(6): 667-80

4. Lipfert J., Ödemis V., Engele J.: Grk2 is an Essential Regulator of CXCR7 Signalling in Astrocytes. Cell Mol Neurobiol 2013; 33(1): 111-8

5. Hunger C., Ödemis V., Engele J.: Expression and function of the SDF-1 chemokine receptors CXCR4 and CXCR7 during limb muscle development and regeneration. Exp. Cell Res. 2012; 318: 2178–2190

6. Glisic D., Lehmann C., Figiel F., Ödemis V., Lindner R., Engele J.: A novel cross-talk between endothelin and ErbB receptors controlling glutamate uptake into astrocytes. J Neurochem. 2012; 122(4): 844-55

7. Ödemis V., Lipfert J., Kraft R., Hajek P., Abraham G., Hattermann K., Mentlein R., Engele J.: The presumed atypical chemokine receptor CXCR7 signals through Gi/o proteins in primary rodent astrocytes and human glioma cells. Glia 2012; 60 (3): 372–381

8. Ödemis V., Boosmann K., Küry P., Engele J.: CXCR7 is an active component of SDF-1 signalling in astrocytes and Schwann cells. J. Cell. Sci. 2010; 123(Pt 7): 1081-8

9. Göttle P., Kremer D., Jander S., Ödemis V., Engele J., Hartung HP, Küry P.: Activation of CXCR7 receptor promotes oligodendroglial cell maturation. Ann Neurol. 2010 Dec; 68(6): 915-24

10. Kolodziej A., Schulz S., Guyon, A., Wu D.F., Pfeiffer M., Ödemis V., Hollt V., Stumm R.:Tonic Activation of CXC Chemokine Receptor 4 in Immature Granule Cells Supports Neurogenesis in the Adult Dentate Gyrus. J. Neuroscience. 2008; 28 (17): 4488-4500

11. Ödemis V., Boosmann K., Dieterlen MT, Engele J.: The chemokine SDF-1 controls multiple steps of myogenesis through atypical PKCzeta..  J. Cell. Sci. 2007; 120(Pt 22): 4050-9

12. Ödemis V., Lamp E., Pezeshki G., Moepps B., Schilling K., Gierschik P., Littman DR, Engele J.: Mice deficient in the chemokine receptor CXCR4 exhibit impaired limb innervation and myogenesis. Mol. Cell. Neurosci. 2005; 30(4): 494-505

13. Ödemis V., Moepps B., Gierschik P., Engele J.: Interleukin-6 and cAMP induce stromal cell-derived factor-1 chemotaxis in astroglia by up-regulating CXCR4 cell surface expression. Implications for brain inflammation. J. Biol. Chem. 2002; 277(42): 39801-8

14. Ruf S., Ödemis V., Thasler W., Babl-Weisbarth M., Rose C.: Therapie der Pyoderma fistulans sinifica., Zbl Chir 1998;123:601

15. Evers B., Gerngroß H., Ödemis V.: Tourniquetischämie und intramuskulärer Sauerstoffpartialdruck bei Kniegelenksarthroskopien. In: Hartel W. (eds) Klinik und Forschung in der Chirurgie unter dem Aspekt von Effizienz und Ökonomie. Langenbecks Archiv für Chirurgie, vol 1997. Springer, Berlin, Heidelberg

16. Evers B., Ödemis V., Gerngross H.: Intramuscular oxygen partial pressure in patients with chronic exertional compartment syndrome (CECS). Adv. Exp. Med. Biol. 1997; 428: 311-316

17. Evers B., Ödemis V., Gerngross H.: Oxygen partial pressure in the anterior tibial muscle during and after knee surgery with tourniquet control. Adv. Exp. Med. Biol. 1997; 428: 317-325

Dr. rer. nat. Nicola Brandt

+49 (0)441 798 3774

W34-0-006

Kurzbiographie

Derzeitige Position

seit 2017     
Wissenschaftliche Mitarbeiterin der Abteilung Anatomie im Department Humanmedizin der Carl von Ossietzky Universität Oldenburg

Akademische Ausbildung und wissenschaftlicher Werdegang

seit 2017         
Wissenschaftliche Mitarbeiterin in der Abteilung Anatomie im Department Humanmedizin der Carl-von-Ossietzky Universität Oldenburg

2010 - 2016    
Wissenschaftliche Mitarbeiterin am Institut für Neuroanatomie, Centrum für Experimentelle Medizin, Universitätsklinikum Hamburg-Eppendorf

2004 -  2009   
Wissenschaftliche Mitarbeiterin am Institut für Zell- und Neurobiologie, Centrum für Anatomie, Charité – Universitätsmedizin Berlin

Promotionsthema: „Die Bedeutung von CALEB/NGC für die Ausdifferenzierung von Dendritenbäumen“                       
Bewertung: summa cum laude

2003 – 2004   
Wissenschaftliche Mitarbeiterin in der Abteilung für Zellbiologie am Zoologischen Institut, Technische Universität Carolo-Wilhelmina zu Braunschweig

1998 - 2003    
Studium der Biologie an der Technischen Universität Carolo-Wilhelmina zu Braunschweig; Diplomarbeit in der Abteilung für Zellbiologie am Zoologischen Institut, Technische Universität Carolo-Wilhelmina zu Braunschweig

Diplomthema: „Einfluss der Phosphorylierung des Mikrofilamentproteins Profilin auf seine Interaktion mit verschiedenen Liganden“

Mitgliedschaften in wissenschaftlichen Fachgesellschaften

  • Neurowissenschaftliche Gesellschaft
  • Deutsche Anatomische Gesellschaft

Publikationen

1. Brandt N, Vierk R, Fester L, Anstötz M, Zhou L, Heilmann LF, Kind S, Steffen P, Rune GM (2019) Sex-specific Difference of Hippocampal Synaptic Plasticity in Response to Neurosteroids; Cereb Cortex 2019 Dec 4. Pii:bhz265.doi: 10.1093/cercor/bhz265

2. Brandt N, Rune GM (2019) Sex-dependency of oestrogen-induced structural synaptic plasticity: Inhibition of aromatase versus application of estradiol in rodents; Eur J Neurosci 2019 Aug 12. Doi: 10.1111/ejn.14541.

3. Meseke M, Pröls F, Schmahl C, Seebo K, Kruse C, Brandt N, Fester L, Zhou L, Bender R, Rune GM (2018) Reelin and aromatase cooperate in ovarian follicle development; Sci Rep 2018 Jun 7;8(1):8722. doi: 10.1038/s41598-018-26928-x.

4. Bender RA, Zhou L, Vierk R, Brandt N, Keller A, Gee CE, Schäfer MKE, Rune GM (2016) Sex-dependence of aromatase-mediated synaptic plasticity in the basolateral amygdala; J Neurosci, 2017;37(6):1532-1545.

5. Fester L, Brandt N, Windhorst S, Pröls F, Bläute C, Rune GM (2015) Control of aromatase in hippocampal neurons. J Steroid Biochem Mol Biol. 2015 Oct12.  pii: S0960-0760(15)30109-6. doi: 10.1016/j.jsbmb.2015.10.009. [Epub ahead of print] Review.

6. Koester JD, Leggewie B, Blechner C, Brandt N, Fester L, Rune GM, Schweizer M, Kindler S, Windhorst S (2015) Inositol, 1,4,5- triphosphate-3kinase-A controls morphology of hippocampal dendritic spines. Cell Signal. 2015 Oct 28. pii: S0898-6568(15)00309-5. doi: 10.1016/j.cellsig.2015.10.016. [Epub ahead of print].

7. Brandt N, Vierk R, Fester L, Zhou L, Imholz P, Rune GM (2014) Gender and the effects of steroid hormones in the central nervous system. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2014 Sep;57(9):1054-60. doi: 10.1007/s00103-014-2014-4. German.

8. Vierk R, Brandt N, Rune GM (2014) Hippocampal estradiol synthesis and its significance for hippocampal synaptic stability in male and female animals. Neuroscience. 2014 May 15;274C:24-32. doi: 10.1016/j.neuroscience.2014.05.003. [Epub ahead of print] Review.

9. Zhou L, Fester L, Haghshenas S, de Vrese X, Hacht RV, Gloger S, Brandt N, Bader M, Vollmer G, Rune GM (2014) Oestradiol-induced synapse formation in the female hippocampus: roles of estrogen receptor subtypes. J Neuroendocrinol. 2014 Apr 30. doi: 10.1111/jne.12162. [Epub ahead of print].

10. Prange-Kiel J, Schmutterer T, Fester L, Zhou L, Imholz P, Brandt N, Vierk R, Jarry H, Rune GM (2013) Endocrine regulation of estrogen synthesis in the hippocampus? Prog Histochem Cytochem. 2013 Jul 29. doi:pii: S0079-6336(13)00013-2. 10.1016/j.proghi.2013.07.002. [Epub ahead of print].

11. Brandt N, Vierk R, Rune GM (2013) Sexual dimorphism in estrogen-induced synaptogenesis in the adult hippocampus. Int J Dev Biol. 2013;57(5):351-6. doi: 10.1387/ijdb.120217gr.

12. Vierk R, Glassmeier G, Zhou L, Brandt N, Fester L, Dudzinski D, Wilkars W, Bender RA, Lewerenz M, Gloger S, Graser L, Schwarz J, Rune GM (2012) Aromatase inhibition abolishes LTP generation in female mice by destabilizing the spine cytoskeleton. J Neurosci, 2012.

13. Wilkars W, Liu Z, Lewis AS, Stoub TR, Ramos EM, Brandt N, Nicholson DA, Chetkovich DM, Bender RA (2012) 1. Regulation of axonal HCN1 trafficking in perforant path involves expression of specific TRIP8b isoforms. PLoS One. 2012;7(2):e32181. Epub 2012 Feb 21.

14. Brandt N, Franke K, Johannes S, Buck F, Harder S, Hassel B, Nitsch R, and Schumacher S (2008) B56b, a regulatory subunit of protein phosphatase 2A, interacts with CALEB/NGC and inhibits CALEB/NGC-mediated dendritic branching. FASEB J, 2008 Jul;22(7):2521-33. Epub 2008 Apr 2.

15. Brandt N, Franke K, Rasin MR, Baumgart J, Vogt J, Khrulev S, Hassel B, Pohl EE, Sestan N, Nitsch R, and Schumacher S (2007) The neural EGF family member CALEB/NGC mediates dendritic tree and spine complexity. EMBO J 26, 2371-2386.

Dr. Joachim Hanke

+49 (0)441 798 3451

W34-0-007

Kurzbiographie

Derzeitige Position

seit 2020
wissenschaftlicher Mitarbeiter der Abteilung Anatomie im Department Humanmedizin der Carl von Ossietzky Universität Oldenburg

Akademische Ausbildung und wissenschaftlicher Werdegang

2001 – 2006
Wissenschaftlicher Assistant am Institut für Anatomie der Medizinischen Fakultät in Magdeburg

1999 – 2001
Wissenschaftlicher Assistant am Institut für Medizinische Psychologie der Medizinischen Fakultät in Magdeburg

1996 – 1999
Wissenschaftlicher Mitarbeiter am Institut für Anatomie der Medizinischen Hochschule Hannover

1995 – 1996
Wissenschaftlicher Mitarbeiter am Institut für Anatomie der Medizinischen Fakultät in Frankfurt a.M.

1993 – 1994
Wissenschaftlicher Mitarbeiter in der Abteilung Zoophysiologie der Universität Oldenburg

1990 – 1993
Stipendiat des Landes Niedersachsen als Doktorand in der Abteilung Zoophysiologie der Universität Oldenburg

Promotionsthema: 
Lokalisierung, Charakterisierung und Isolierung des Opiatrezeptors bei Crustaceen
Bewertung: summa cum laude

1985 – 1990
Studium der Biologie an der Universität Oldenburg, Grade Point Average: 1.0
Diplomthema:
Autoradiographische und immuncytochemische Untersuchungen ultramikroskopischer Strukturen des neuroendokrinen Systems der Crustaceen

Publikationen

  1. Wickramasekaraa, Rochelle N.; Bockman, Charles; Hanke, Joachim; Schwegler, Herbert; McGeed, JoAnn; Walsh, Edward; Yilmazer-Hanke, Deniz. (2020). Alpha2-adrenergic dysregulation in congenic DxH recombinant inbred mice selectively bred for a high fear-sensitized (H-FSS) startle response. Pharmacology, Biochemistry and Behavior. 188. 172835
     
  2. Yilmazer-Hanke, Deniz; Eliava, Marina; Hanke, Joachim; Schwegler, Herbert; Asan, Esther. (2016). Density of Acetylcholine Esterase (AchE) and Tyrosine Hydroxylase (TH) Containing Fibers in the Amygdala of Roman High- and Low-Avoidance Rats. Neuroscience letters. 632. 114-8.
     
  3. Browne, Caroline; Hanke, Joachim; Rose, Claudia; Walsh, Irene; Foley, Tara; Clarke, Gerard;Schwegler, Herbert; Cryan, John; Yilmazer-Hanke, Deniz. (2014). Effect of Acute Swim Stress on Plasma Corticosterone and Brain Monoamine Levels in Bidirectionally Selected DxH Recombinant Inbred Mouse Strains Differing in Fear Recall and Extinction. Stress (Amsterdam, Netherlands). 17. 1-36.
     
  4. Browne, Caroline; Clarke, Gerard; Hanke, Joachim; G Dinan, Timothy; Schwegler, Herbert; Yilmazer-Hanke, Deniz; Cryan, John. (2013). Alterations in prefrontal cortical serotonin and antidepressant-like behavior in a novel C3H/HeJxDBA/2J recombinant inbred mouse strain. Behavioural brain research. 236. 283-8.
     
  5. Rose, Claudia; Schwegler, Herbert; Hanke, Joachim; Yilmazer-Hanke, Deniz. (2012). Pregnancy rates, prenatal and postnatal survival of offspring, and litter sizes after reciprocal embryo transfer in DBA/2JHd, C3H/HeNCrl and NMRI mice. Theriogenology. 77. 1883-93.
     
  6. Frisch, Christian; Hanke, Joachim; Kleinerüschkamp, Sven; Roeske, Sandra; Kaaden, Sabine; Elger, Christian; Schramm, Johannes; Yilmazer-Hanke, Deniz; Helmstaedter, Christoph. (2009). Positive Correlation Between the Density of Neuropeptide Y Positive Neurons in the Amygdala and Parameters of Self-Reported Anxiety and Depression in Mesiotemporal Lobe Epilepsy Patients. Biological psychiatry. 66. 433-40.
     
  7. Rose, Claudia; Röhl, Friedrich-Wilhelm; Hanke, Joachim; Schwegler, Herbert; Yilmazer-Hanke, Deniz. (2008). Maternal and Genetic Effects on the Acoustic Startle Reflex and its Sensitization in C3H/HeN, DBA/2JHd and NMRI Mice Following Blastocyst Transfer. Behavior genetics. 38. 596-611.
     
  8. Rose, Claudia; Schwegler, Herbert; Hanke, Joachim; Röhl, Friedrich-Wilhelm; Yilmazer-Hanke, Deniz. (2006). Differential effects of embryo transfer and maternal factors on anxiety-related behavior and numbers of neuropeptide Y (NPY) and parvalbumin (PARV) containing neurons in the amygdala of inbred C3H/HeN and DBA/2J mice. Behavioural brain research. 173. 163-8.
     
  9. Rose, Claudia; Röhl, Friedrich-Wilhelm; Schwegler, Herbert; Hanke, Joachim; Yilmazer-Hanke, Deniz. (2006). Maternal and Genetic Effects on Anxiety-Related Behavior of C3H/HeN, DBA/2J and NMRI Mice in a Motility-Box Following Blastocyst Transfer. Behavior genetics. 36. 745-62.
     
  10. Roskoden, Thomas; Hanke, Joachim; Yilmazer-Hanke, Deniz; Schwegler, Herbert. (2005). Reduced number of CRF-containing neurons in the central amygdala correlated with enhanced locomotor activity following early postnatal corticosterone treatment in the Wistar rat. Behavioural brain research. 165. 221-8.
     
  11. Yilmazer-Hanke, Deniz; Hantsch, M; Hanke, Joachim; Schulz, Carla; Faber-Zuschratter, Heidi; Schwegler, Herbert. (2004). Neonatal thyroxine treatment: Changes in the number of corticotropinreleasing-factor (CRF) and neuropeptide Y (NPY) containing neurons and density of tyrosine hydroxylase positive fibers (TH) in the amygdala correlate with anxiety-related behavior of Wistar rats. Neuroscience. 124. 283-97.
     
  12. Hanke, Joachim; Sabel, Bernhard. (2004). L-type calcium channel antagonist nifedipine reduces neurofilament restitution following traumatic optic nerve injury. Acta neurochirurgica. Supplement. 89. 75-80.
     
  13. Hanke, Joachim; Sabel, Bernhard. (2002). Anatomical correlations of intrinsic axon repair after partial optic nerve crush in rats. Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 184. 113-23.
     
  14. Hanke Joachim (2001): Apoptosis in cultured islets of Langerhans and occurrence of Bcl-2, Bak, Bax, Fas and FasL. Cell Tissues Organs 169: 113-124.
     
  15. Hanke Joachim (2000) Apoptosis and occurrence of Bcl-2, Bak, Bax, Fas and FasL in the developing and adult rat endocrine pancreas. Anat Embryol 202: 303-312.
     
  16. Yilmazer-Hanke D, Hanke J (1999): Progression of Alzheimer-related neuritic plaque pathology in the entorhinal region, perirhinal cortex, and hippocampal formation. Dement Geriatr Cogn Disord 10: 70-76.
     
  17. Nagy Z, Yilmazer DM, Braak H, Braak E, Schultz C, Hanke J (1998): Assessment of the pathological stages of Alzheimer’s disease in thin paraffin sections: A comparative study. Dement Geriatr Cogn Disord 9: 140-144.
     
  18. Nagy Z, Vatter-Bittner B, Braak H, Braak E, Yilmazer DM, Schultz C, Hanke J (1997): Staging of Alzheimer-type pathology: An interrater-intrarater study. Dement Geriatr Cogn Disord 8: 248-251.
     
  19. Hanke J, Yilmazer-Hanke DM (1997): Pigmentarchitectonic subfields of the entorhinal region as revealed in tangential sections. J Brain Res 38: 427-432.
     
  20. Hanke J, Yilmazer-Hanke DM (1997): Variabilities in the distribution of neurofibrillary tangles in the anterior parahippocampal gyrus at initial stages of Alzheimer’s disease. Clin. Neuropathol 16: 299-302.
     
  21. Hanke J (1997): Sulcal pattern of the anterior parahippocampal gyrus in the human adult. Ann Anat 179: 335-339.
     
  22. Hanke J, Willig A, Yinon U, Jaros PP (1997): Delta and kappa opioid receptors in eyestalk ganglia of a crustacean. Brain Res. 744: 279-284.
     
  23. Hanke J, Willig A, Jaros PP (1996): Opioid receptor types for endogenous enkephalin in the thoracic ganglion of the crab, Carcinus maenas. Peptides 17: 965-972.
     
  24. Hanke J, Jaros PP, Willig A (1993): Ultrastructural autoradiographic localization of opiod receptors on membranes with CHH immunogold detected axon terminals in a neurohemalorgan of Carcinus maenas L.. Histochem. 99: 405-410.
     
  25. Hanke J, Jaros PP, Willig A (1992): Differential localization of leu-enkephalin in axon terminals of the sinus gland of the crabs Carcinus maenas L., Eriocheir sinensis and Uca pugilator. Cell Tissue Res. 270: 521-526.

Dr. Gürkan Bal

+49 (0)441 798 3451

W34-0-007

Kurzbiographie

Derzeitige Position

seit 2020       
Wissenschaftlicher Mitarbeiter zur Habilitation
in der Abteilung Anatomie im Department Humanmedizin der Carl von Ossietzky Universität Oldenburg
 

Akademische Ausbildung und wissenschaftlicher Werdegang

2016 - 2019
Wissenschaftlicher Mitarbeiter (Postdoktorand) am Institut für Zell- und Neurobiologie, Centrum für Anatomie, Charité – Universitätsmedizin Berlin

2011 - 2016
Wissenschaftlicher Mitarbeiter (Postdoktorand)
am Institut für Transfusionsmedizin, Charité–Universitätsmedizin Berlin

2007 - 2011
Wissenschaftlicher Mitarbeiter (Promovend)
am Institut für Transfusionsmedizin, Charité–Universitätsmedizin Berlin

Promotionsthema:
Molekulares Profiling des hämatopoetischen Supports Interleukin-stimulierter Endothelzellen

Bewertung: magna cum laude

2004-2006
Forschung Trainee
am Institut für Transfusionsmedizin, Charité–Universitätsmedizin Berlin

Thema: Die Rolle des B-Zell aktivierenden Faktors (BAFF) in Immunthrombozytopenie

1998-2001
Biomediziner
im Labor für Klinische Biochemie, Medizinische Fakultät Cerrahpaşa der Universität Istanbul

1999-2001
Studium M.Sc. Biologie,
Gebze Institut für Technologie, Türkei

1994-1998
Studium B.Sc. Biomedizinische Wissenschaften
, Medizinische Fakultät Cerrahpaşa der Universität Istanbul

Publikationen

1.  Bal, G*; Depré F*, Dzamashvili M, Ringel F, Salama A. Effect of thrombopoietin receptor agonists on leucocyte and haematopoietic stem and progenitor cell in peripheral blood of patients with immune thrombocytopenia. Annals of Hematology, 2017.

2.  Cecilia B, Seval T, Ulrich R, Lars F, Bal G, Schulz CO, Hemmati P, Renate A, Hanno R, Philipp le C. A Rare Case of Acute Myeloid Leukemia with a t(2;3) Chromosomal Translocation Characterized by Thrombophilia and Chemoresistance. J Clin Exp Hematop. 2016.

3. Kohn B., Bal G., Chirek A., Rehbein S., Salama A. Romiplostim treatment in dogs as a natural animal model for refractory immune thrombocytopenia. BMC Veterinary Research (2016).

 4.  Bal G, Salama, A at all, Identification of novel biomarkers in chronic immune thrombocytopenia (ITP) by microarray-based serum protein profiling. Br J Haematol. (2015).

 5. Kamhieh-Milz J, Moftah RF, Bal G, Futschik M, Sterzer V, Khorramshahi O, Burow M, Thiel G, Stuke-Sontheimer A, Chaoui R, Kamhieh-Milz S, Salama A. Differentially expressed microRNAs in maternal plasma for the noninvasive prenatal diagnosis of Down syndrome (trisomy 21). Biomed Res Int. (2014)

 6. Bal G, Kamhieh-Milz J, Sterzer V, Al-Samman M, Debski J, Klein O, Kamhieh-Milz S, Bhakdi S, Salama, A. Proteomic profiling of secreted proteins for the hematopoietic support of interleukin-stimulated human umbilical vein endothelial cells.  Cell Transplant. (2012).

7. Kamhieh-Milz J, Bal G, Sterzer V, Kamhieh-Milz S, Arbach O, Salama A. Reduced antioxidant capacities in platelets from patients with autoimmune thrombocytopenia purpura (ITP) Platelets (2012).

 8.  Bal G, Kamhieh-Milz J, Futschik M, Haupl T, Salama A, Moldenhauer A. Transcriptional profiling of the hematopoietic support of interleukin-stimulated human umbilical vein endothelial cells (HUVECs). Cell Transplant. (2011).

9. Moldenhauer A, Futschik M, Lu H, Helmig M, Götze P, Bal G, Zenke M, Han W,Salama A. Interleukin 32 promotes hematopoietic progenitor expansion and attenuates bone marrow cytotoxicity. Eur J Immunol. (2011).

10.  Moldenhauer A, Genter G, Lun A, Bal G, Kiesewetter H, Salama A. Hematopoietic progenitor cells and interleukin-stimulated endothelium: expansion and differentiation of myeloid precursors. BMC Immunol. (2008).

 11.  Emmerich F*, Bal G*, Barakat A, Milz J, Mühle C, Martinez-Gamboa L, Dörner T, Salama A. High-level serum B-cell activating factor and promoter polymorphisms in patients with idiopathic thrombocytopenic purpura. Br J Haematol. (2007).

Ph.D.-Studierende

Anne Gläser, Dipl. Biol.

+49 (0)441 798 3934

W34-0-007

Kurzbiographie

Derzeitige Position:

seit Okt. 2017      
Doktorandin und wissenschaftliche Mitarbeiterin an der Carl von Ossietzky Universität Oldenburg Department für Humanmedizin, Abteilung Anatomie                                                     

Akademische Ausbildung und wissenschaftlicher Werdegang

2015 – 2017   
Doktorandin an der Universitätsmedizin Rostock, Institut für Anatomie, Arbeitsgruppe Molekulare Neurobiologie

Promotionsthema: Analysis of lipid metabolism changes in NPC1 mouse model with different treatment strategies

2014 - 2017    
Wissenschaftliche Mitarbeiterin der Universitätsmedizin Rostock, Institut für Anatomie

2006 - 2012   
Studium der Biowissenschaften an der Universität Rostock

Diplomarbeit am Albrecht-Kossel Institut für Neuroregeneration, Rostock

Thema der Diplomarbeit: Untersuchungen zur Aktivitätssteigerung der

Alpha-Galaktosidase A mittels potentieller Modifier-Gene

Schulische Ausbildung 

2003 - 2006   
Allgemeine Hochschulreife
am beruflichen Gymnasium Oelsnitz/Erzgebirge,
Fachrichtung: Informations- und Kommunikationstechnologie

Publikationen

1. Gläser A, Hammerl F, Gräler MH, Coldewey SM, Völkner C, Frech MJ, Yang F, Luo J, Tönnies E, von Bohlen Und Halbach O, Brandt N, Heimes D, Neßlauer AM, Korenke GC, Owczarek-Lipska M, Neidhardt J, Rolfs A, Wree A, Witt M, Bräuer AU.  Identification of Brain-Specific Treatment Effects in NPC1 Disease by Focusing on Cellular and Molecular Changes of Sphingosine-1-Phosphate Metabolism. Int J Mol Sci. 2020 Jun 24;21(12):E4502. doi: 10.3390/ijms21124502.

2. Feng X, Yang F, Rabenstein M, Wang Z, Frech M, Wree A, Bräuer AU, Witt M., Gläser A., Hermann A., Rolfs A, Luo J, Stimulation of mGluR1/5 improves defective internalization of AMPA receptors in NPC1 mutant mouse, Cerebral Cortex, 2019, Oct 10

3. Neßlauer A-M., Gläser A., Gräler M., Engelmann R., Müller-Hilke B., Frank M., Burstein C., Rolfs A., Wree A., Witt M., Bräuer AU. A therapy with miglustat, 2-hydroxypropyl-ß-cyclodextrin and allopregnanolone restores splenic cholesterol homeostasis in Niemann-Pick Disease Type C1. Lipids Health Dis., 2019 June, 18:146

4. Meyer A,*, Gläser A.*, Bräuer AU., Wree A., Strotmann J., Rolfs A., Witt M. Olfactory performance as an indicator for protective treatment effects in an animal model of neurodegeneration, Front. Integr. Neurosci. 2018 Aug. 12;12:35

5. Ebner L., Gläser A., Bräuer AU., Witt M., Wree A., Rolfs A., Frank M., Vollmar B., Kuhla A. Evaluation of Two Liver Treatment Strategies in a Mouse Model of Niemann-Pick-Disease Type C1., Int. J. Mol. Sci., 2018 Mar, 19 (4): 972

6. Reetz J., Hildebrandt S., Schmidt A., Meier C., Herchenroder O., Gläser A., Witt M., Pützer BM., Wree A., Novel subventricular zone early progenitor cell-specific adenovirus for in vivo therapy of central nervous system disorders reinforces brain stem cell heterogeneity, Brain structure & function, 2015 May, 221 (4): 2049-59

7. Lukas J., Pockrandt A., Seemann S., Sharif M., Runge F., Pohlers S., Zheng C., Gläser A., Beller M., Rolfs A., Giese A., Enzyme Enhancers for the treatment of Fabry and Pompe Disease, Molecular Therapy , 2015 Mar, 23 (3): 456-464


*Contributed equally as first author.

Isabel Groß, M.Sc.

+49 (0)441 798 3791

W34-0-007

Kurzbiographie

Derzeitige Position:

seit Sep. 2017  
Doktorandin und wissenschaftliche Mitarbeiterin  an der Carl von Ossietzky Universität Oldenburg, Department für Humanmedizin, Abteilung Anatomie                                                        

Akademische Ausbildung und wissenschaftlicher Werdegang

2015 – 2017   
Doktorandin an der Universitätsmedizin Rostock, Institut für Anatomie, Arbeitsgruppe Molekulare Neurobiologie

Promotionsthema: Funktionelle Untersuchung der PRG5-PtdInsP Interaktion und ihrer Rolle in neurodegenerativen Erkrankungen

2014 – 2015   
Wissenschaftliche Mitarbeiterin am Max-Delbrück-Center für Molekulare Medizin, Berlin

2011 - 2014    
Masterstudium der Biologie, Schwerpunkt Neurobiologie an der Freien Universität Berlin

Masterarbeit am Max-Delbrück-Center für Molekulare Medizin, Berlin:

Neurexin Expression verschiedener embryonaler und postnataler Entwicklungsstadien des Zentralnervensystems der Maus.

2011 - 2014   
Bachelorstudium der Biologie, an der Universität Hohenheim, Stuttgart

Bachelorarbeit an der Universität Hohenheim, Stuttgart

Zellmodifizierende Eigenschaften niedermolekularer Komponenten aus dem Gift von Crotalus durissus terrificus.

Schulische Ausbildung

2000 - 2008   
Allgemeine Hochschulreife
am Goethe-Gymnasium Ludwigsburg

Mitgliedschaften in wissenschaftlichen Fachgesellschaften

  • Neurowissenschaftliche Gesellschaft                    

Publikationen

1. Gross I, Bräuer AU. Modulation of LPA Receptor Activity: the key to successful neural regeneration? Neural Regen Res, 2020 15(1):53-54

2. Brand I., Groß I., Li D., Zhang Y., Bräuer AU. Pneumatic conveying printing technique for bioprinting applications. RSCAdv., 2019, 9, 40910: DOI: 10.1039/c9ra07521f

3. Suckau O.*, Gross I.*, Schrötter S., Yang F., Luo J., Wree A., Chun J., Baska D., Baumgart J., Kano K., Aoki J., Bräuer AU. LPA1, LPA2, LPA4, and LPA6 receptor expression during mouse brain development. Developmental Dynamics, 2019 Mar 8

Fatemah Sakr, MD in Kooperation mit Prof. Stefan Teipel, DZNE, Rostock

+49 (0)441 798 3797

W34-0-007

                 

Kurzbiographie

A PhD candidate in the University of Rostock within the framework of Blood Biomarkers-based Diagnostic Tools for Early-stage Alzheimer’s Disease (BBDiag) Project. She received her master’s degree in Diagnostic and Interventional Radiology from Ain Shams University, Egypt in 2012. Then she received training as a neuroradiology fellow in Misr radiology center (MRC), where she acquired experience in advanced MRI Techniques & applications in neuroimaging. Currently, she is working on the Imaging Biomarkers as a predictive tool in preclinical stage of Alzheimer’s disease. In collaboration with Oldenburg University, she is exploring the Lipidomic signature of Alzheimer’s disease as an initial step to further promote potential candidates as reliable biomarkers in the initial phases of the disease.

Yaoyu Chen, Kooperation mit Prof. Dr. Karl-Wilhelm Koch

+49 (0)441 798 3451

W34-0-007     > Department für Neurowissenschaften
Biochemie
Prof. Dr. Karl-Wilhelm Koch

Kurzbiographie

Derzeitige Position:

seit November 2018
Doktorand und wissenschaftlicher Mitarbeiter  an der Carl von Ossietzky Universität Oldenburg                                                     

Bildung:

2014 - 2017
Master of Medicine (Biomedical engineering): Jilin University School of Pharmaceutical Sciences, Changchun, China

2010 - 2014
Bachelor of Engineering (Bio-pharmaceuticals): Zhuhai College of Jilin University, Zhuhai, China

 

Forschungsarbeiten:

2014 - 2015
Course studies at Jilin University

2015 - 2017
Cooperation research program at Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences.
Graduate issue:
Generation of Larger Teeth from Human iPS Cells with Pig Dental Mesenchyme.

 

Publikationen

1. Jia B, Huang L, Chen Y, Liu S, Chen C, Xiong K, Song L, Zhou Y, Yang X, Zhong M. A novel contiguous deletion involving NDP, MAOB and EFHC2 gene in a patient with familial Norrie disease: bilateral blindness and leucocoria without other deficits. J Genet. 2017 Dec;96(6):1015-1020.

2. Yang Y, Zhao Y, Liu X, Chen Y, Liu P*, Zhao L. Effect of SOX2 on odontoblast differentiation of dental pulp stem cells. Mol Med Rep. 2017 Oct 17; 10.3892

3. Zhao L, Feng Y, Chen X, Yuan J, Liu X, Chen Y, Zhao Y, Liu P*, Li Y. Effects of IGF-1 on neural differentiation of human umbilical cord derived mesenchymal stem cells. Life Sci. 2016 Apr 15;151:93-101.

4. Liu P, Feng Y, Dong D, Liu X, Chen Y, Wang Y, Zhou Y*. Enhanced renoprotective effect of IGF-1 modified human umbilical cord-derived mesenchymal stem cells on gentamicin-induced acute kidney injury. Sci Rep. 2016 Feb 2; 6:20287.

5. Liu P, Cai J, Dong D, Chen Y, Liu X, Wang Y, Zhou Y*. Effects of SOX2 on Proliferation, Migration and Adhesion of Human Dental Pulp Stem Cells. PLoS One. 2015 Oct 23;10(10).

Natalie Gray, M. Sc. in Kooperation mit Prof. Dr. Ulrike Raap

+49 (0)441 798 3451

W34-0-007     > Department für Humanmedizin
Abteilung für experimentelle Allergologie und Immundermatologie
Prof. Dr. Ulrike Raap

Technische Mitarbeiterin

Jennifer Sevecke-Rave

+49 (0)441 798 3776

W34-0-007

Beate Bous

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