Publikationen

Kontakt

Direktor der Universitätsklinik für Augenheilkunde

Univ.-Prof. Dr. Dr. med. Stefan Schrader

Leitung des Labors für Experimentelle Ophthalmologie

Dr. rer. nat. Sonja Mertsch

Sekretariat im Pius-Hospital Oldenburg

+49 (0)441 229 1241

+49 (0)441 229 1277

Anschrift

Carl von Ossietzky Universität Oldenburg
Fakultät VI Medizin und Gesundheitswissenschaften
Department für Humanmedizin
Postfach 5634
26046 Oldenburg

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Lehrbeauftragte:

Dr. rer. nat. Sonja Mertsch

Publikationen

2021

[1] S. Mertsch, I. Neumann, C. Rose, M. Schargus, G. Geerling, S. Schrader, The effect of Rho Kinase inhibition on corneal nerve regeneration in vitro and in vivo, Ocul Surf 22 (2021) 213-223. (awarded with the Hermine Heusler-Edenhuizen”Best Paper” Award 2022 from the University Oldenburg and the Freunde und Förderer der Universitätsmedizin Nordwest e.V.)

[2] F. Song, M. Owczarek-Lipska, T. Ahmels, M. Book, S. Aisenbrey, M. Menghini, D. Barthelmes, S. Schrader, G. Spital, J. Neidhardt, High-Throughput Sequencing to Identify Mutations Associated with Retinal Dystrophies, Genes (Basel) 12(8) (2021).

[3] J. Menzel-Severing, S. Schrader, U. Schlotzer-Schrehardt, G. Geerling, Transcorneal freezing and topical Rho-kinase inhibitor treatment in Fuchs endothelial corneal dystrophy, Eye (Lond)  (2021).

[4] L. Juergens, S. Michiels, M. Borrelli, K. Spaniol, R. Guthoff, S. Schrader, A. Frings, G. Geerling, Intraoperative OCT - Real-World User Evaluation in Routine Surgery, Klin Monbl Augenheilkd 238(6) (2021) 693-699.

[5] M. Hasenzahl, M. Musken, S. Mertsch, S. Schrader, S. Reichl, Cell sheet technology: Influence of culture conditions on in vitro-cultivated corneal stromal tissue for regenerative therapies of the ocular surface, J Biomed Mater Res B Appl Biomater 109(10) (2021) 1488-1504.

 

2020

[1] S. Mertsch, M. Hasenzahl, S. Reichl, G. Geerling, S. Schrader, Decellularized human corneal stromal cell sheet as a novel matrix for ocular surface reconstruction, J Tissue Eng Regen Med 14(9) (2020) 1318-1332.

[2] J. Witt, J. Dietrich, S. Mertsch, S. Schrader, K. Spaniol, G. Geerling, Decellularized porcine conjunctiva as an alternative substrate for tissue-engineered epithelialized conjunctiva, Ocul Surf 18(4) (2020) 901-911.

[3] A. Stitt, S. Schrader, Ocular Regeneration - Where are We and What s on the Horizon, Curr Eye Res 45(3) (2020) 229.

[4] U. Pleyer, G. Geerling, S. Schrader, C. Jacobi, F. Kimmich, E. Messmer, [If Artificial Tears Aren't Enough. The Importance of Inflammatory Processes in Dry Eye Disease. Practical Aspects of an Anti-Inflammatory Therapy of Dry Eye Disease], Klin Monbl Augenheilkd 237(5) (2020) 655-668.

[5] K. Ou, D.A. Copland, S. Theodoropoulou, S. Mertsch, Y. Li, J. Liu, S. Schrader, L. Liu, A.D. Dick, Treatment of diabetic retinopathy through neuropeptide Y-mediated enhancement of neurovascular microenvironment, J Cell Mol Med 24(7) (2020) 3958-3970.

 [6] J. Dietrich, S. Schrader, Towards Lacrimal Gland Regeneration: Current Concepts and Experimental Approaches, Curr Eye Res 45(3) (2020) 230-240.

 

2019 - 2015

[1] N. Feltgen, K.U. Bartz-Schmidt, N. Feltgen, F. Grehn, J. Lauermann, P. Maier, R. Merte, S. Pitz, N. Plange, I. Schmack, M. Altmann, G. Auffarth, M. Bohm, V. Brucher, L. Choritz, C. Deuter, N. Feltgen, M. Fuest, C. Girbhardt, A. Hassenstein, C. Holtmann, J. Kampmeier, K. Lenz, K. Loffler, B. Lorenz, P. Maier, C. Mardin, S. Mertsch, P. Moller, A. Mohi, V. Muller, M. Nentwich, A. Neugebauer, A. Pielen, U. Pleyer, V. Prokosch, I. Schmack, S. Schulze, B. Seitz, A. Stahl, N. Terai, F. Treumer, R. Wienrich, H. Ilhelm, D.-A. Lehre, G.O. Lehrbe, Ophthalmological student teaching-results of a survey at German universities, Ophthalmologe  (2019).

[2] J. Witt, M. Borrelli, S. Mertsch, G. Geerling, K. Spaniol, S. Schrader, Evaluation of Plastic-Compressed Collagen for Conjunctival Repair in a Rabbit Model, Tissue Eng Part A 25(15-16) (2019) 1084-1095.

[3] K. Ou, S. Mertsch, S. Theodoropoulou, J. Wu, J. Liu, D.A. Copland, L.M. Scott, A.D. Dick, S. Schrader, L. Liu, Muller Cells Stabilize Microvasculature through Hypoxic Preconditioning, Cell Physiol Biochem 52(4) (2019) 668-680.

[4] K. Ou, S. Mertsch, S. Theodoropoulou, J. Wu, J. Liu, D.A. Copland, S. Schrader, L. Liu, A.D. Dick, Corrigendum to "Restoring retinal neurovascular health via substance P" [Exp. Cell Res. (2019)], Exp Cell Res 382(2) (2019) 111482.

[5] K. Ou, S. Mertsch, S. Theodoropoulou, J. Wu, J. Liu, D.A. Copland, S. Schrader, L. Liu, A.D. Dick, Restoring retinal neurovascular health via substance P, Exp Cell Res 380(2) (2019) 115-123.

[6] S. Mertsch, J. Alder, H.S. Dua, G. Geerling, [Pathogenesis and epidemiology of neurotrophic keratopathy], Ophthalmologe 116(2) (2019) 109-119.

[7] P. Enders, J. Hall, M. Bornhauser, K. Mansouri, L. Altay, S. Schrader, T.S. Dietlein, B.O. Bachmann, T. Neuhann, C. Cursiefen, Telemetric Intraocular Pressure Monitoring after Boston Keratoprosthesis Surgery Using the Eyemate-IO Sensor: Dynamics in the First Year, Am J Ophthalmol 206 (2019) 256-263.

[8] P. Enders, J. Hall, M. Bornhauser, K. Mansouri, L. Altay, S. Schrader, T.S. Dietlein, B.O. Bachmann, T. Neuhann, C. Cursiefen, Telemetric Intraocular Pressure Monitoring after Boston Keratoprosthesis Surgery, Ophthalmology 126(2) (2019) 322-324.

[9] J. Dietrich, M. Roth, S. Konig, G. Geerling, S. Mertsch, S. Schrader, Analysis of lacrimal gland derived mesenchymal stem cell secretome and its impact on epithelial cell survival, Stem Cell Res 38 (2019) 101477.

[10] J. Dietrich, L. Ott, M. Roth, J. Witt, G. Geerling, S. Mertsch, S. Schrader, MSC Transplantation Improves Lacrimal Gland Regeneration after Surgically Induced Dry Eye Disease in Mice, Sci Rep 9(1) (2019) 18299.

[11] J. Alder, S. Mertsch, J. Menzel-Severing, G. Geerling, [Current and experimental treatment approaches for neurotrophic keratopathy], Ophthalmologe 116(2) (2019) 127-137.

[12] J. Witt, S. Mertsch, M. Borrelli, J. Dietrich, G. Geerling, S. Schrader, K. Spaniol, Decellularised conjunctiva for ocular surface reconstruction, Acta Biomater 67 (2018) 259-269.

[13] K. Spaniol, J. Witt, S. Mertsch, M. Borrelli, G. Geerling, S. Schrader, Generation and characterisation of decellularised human corneal limbus, Graefes Arch Clin Exp Ophthalmol 256(3) (2018) 547-557.

[14] S. Schrader, J. Witt, G. Geerling, Plastic compressed collagen transplantation - a new option for corneal surface reconstruction?, Acta Ophthalmol 96(6) (2018) e757-e758.

[15] S. Mertsch, K. Schlicht, H. Melkonyan, S. Schlatt, S. Thanos, snRPN controls the ability of neurons to regenerate axons, Restor Neurol Neurosci 36(1) (2018) 31-43.

[16] I. Massie, K. Spaniol, A. Barbian, G. Geerling, M. Metzger, S. Schrader, Development of lacrimal gland spheroids for lacrimal gland tissue regeneration, J Tissue Eng Regen Med 12(4) (2018) e2001-e2009.

[17] G. Geerling, S. Schrader, Thank You and Welcome: Editorial Changes in Current Eye Research, Curr Eye Res 43(4) (2018) 443-444.

[18] A. Frings, S. Schrader, K. Hille, I. Staab, G. Geerling, [Health-related quality of life after implantation of a keratoprosthesis with biological haptic], Ophthalmologe 115(1) (2018) 34-39.

[19] J. Dietrich, C. Schlegel, M. Roth, J. Witt, G. Geerling, S. Mertsch, S. Schrader, Comparative analysis on the dynamic of lacrimal gland damage and regeneration after Interleukin-1alpha or duct ligation induced dry eye disease in mice, Exp Eye Res 172 (2018) 66-77.

[20] S. Mertsch, S. Thanos, Analysis of Histone Deacetylase-Dependent Effects on Cell Migration Using the Stripe Assay, Methods Mol Biol 1510 (2017) 61-75.

[21] S. Mertsch, O.H. Kramer, The interplay between histone deacetylases and rho kinases is important for cancer and neurodegeneration, Cytokine Growth Factor Rev 37 (2017) 29-45.

[22] I. Massie, K. Spaniol, A. Barbian, G. Poschmann, K. Stuhler, G. Geerling, M. Metzger, S. Mertsch, S. Schrader, Evaluation of Decellularized Porcine Jejunum as a Matrix for Lacrimal Gland Reconstruction In Vitro for Treatment of Dry Eye Syndrome, Invest Ophthalmol Vis Sci 58(12) (2017) 5564-5574.

[23] I. Massie, J. Dietrich, M. Roth, G. Geerling, S. Mertsch, S. Schrader, Development of Causative Treatment Strategies for Lacrimal Gland Insufficiency by Tissue Engineering and Cell Therapy. Part 2: Reconstruction of Lacrimal Gland Tissue: What Has Been Achieved So Far and What Are the Remaining Challenges?, Curr Eye Res 41(10) (2016) 1255-1265.

[24] J. Dietrich, I. Massie, M. Roth, G. Geerling, S. Mertsch, S. Schrader, Development of Causative Treatment Strategies for Lacrimal Gland Insufficiency by Tissue Engineering and Cell Therapy. Part 1: Regeneration of Lacrimal Gland Tissue: Can We Stimulate Lacrimal Gland Renewal In Vivo?, Curr Eye Res 41(9) (2016) 1131-42.

[25] K. Spaniol, M. Metzger, M. Roth, B. Greve, S. Mertsch, G. Geerling, S. Schrader, Engineering of a Secretory Active Three-Dimensional Lacrimal Gland Construct on the Basis of Decellularized Lacrimal Gland Tissue, Tissue Eng Part A 21(19-20) (2015) 2605-17.

[26] M. Roth, K. Spaniol, C. Kordes, S. Schwarz, S. Mertsch, D. Haussinger, N. Rotter, G. Geerling, S. Schrader, The Influence of Oxygen on the Proliferative Capacity and Differentiation Potential of Lacrimal Gland-Derived Mesenchymal Stem Cells, Invest Ophthalmol Vis Sci 56(8) (2015) 4741-52.

[27] V. Prokosch-Willing, M. Meyer zu Hoerste, S. Mertsch, T. Stupp, S. Thanos, Postnatal visual deprivation in rats regulates several retinal genes and proteins, including differentiation-associated fibroblast growth factor-2, Dev Neurosci 37(1) (2015) 14-28.

(Stand: 20.04.2022)