Der Schwerpunkt unserer Forschungsgruppe liegt auf Autoimmunerkrankungen wie dem bullösen Pemphigoid, Allergien, Hautkrebs und entzündlichen Hauterkrankungen einschließlich atopischer Dermatitis, Kontaktekzemen und Psoriasis. Wir sind besonders an der Rolle von Basophilen und Eosinophilen bei diesen Erkrankungen interessiert, da die aus diesen Zellen freigesetzten Entzündungsmediatoren eine entscheidende Rolle in der Schwere der Symptome spielen und auch auf andere Immunzellen einwirken, die diese Krankheiten steuern. Unsere Gruppe verfügt über langjährige Erfahrung in der Isolierung und Reinigung von menschlichen allergischen Effektorzellen, um deren funktionelle Reaktionen zu untersuchen und um die intrazellulären Signalmechanismen aufzuklären, die ihre Reaktivität kontrollieren. Unser Hauptziel ist es, die verschiedenen Rollen dieser Zellen bei Autoimmunität und Allergien zu verstehen und neue therapeutische Strategien zu entwickeln.

Zu den laufenden internationalen Forschungskooperationen zählen die Universität Groningen (NL), wo wir die Ursachen für die Blasenbildung der Haut beim bullösen Pemphigoid und die Rolle von TRP Kanälen bei atopischer Dermatitis untersuchen.
Zudem sind wir Mitglied der translationalen PruSeach Forschergruppe, die von der Deutschen Forschungsgemeinschaft (DFG) gefördert wird. In enger Kooperation mit der Universität Heidelberg, Düsseldorf, Münster, Mainz, Erlangen und Würzburg hoffen wir die neuartigen Mechanismen des Juckreizes und seiner Verbindung zum Schmerz zu enträtseln und neue Behandlungsziele zu identifizieren. Weitere Kooperationspartner sind die Unversität Leuven (Belgien) und die Medizinische Hochschule Hannover, mit denen wir an grundlegenden Fragestellungen zur Rolle von Entzündungsmediatoren bei chronisch entzündlichen Hauterkrankungen forschen.

mehr

2024

Weihrauch T, Gray N, Meyer NH, Loser K, Raap U. Protocol for autofluorescence-driven isolation of human peripheral blood eosinophils. STAR Protoc. 2024 Nov 19;5(4):103451. doi: 10.1016/j.xpro.2024.103451. Epub ahead of print. PMID: 39565692; PMCID: PMC11617454.

Kött J, Zell T, Zimmermann N, Rünger A, Smit DJ, Abeck F, Geidel G, Hansen-Abeck I, Heidrich I, Weichenthal M, Ugurel S, Leiter U, Berking C, Gutzmer R, Schadendorf D, Zimmer L, Livingstone E, Wasielewski IV, Mohr P, Meier F, Haferkamp S, Drexler K, Herbst R, Kellner I, Utikal J, Wohlfeil SA, Pföhler C, Adam L, Terheyden P, Ulrich J, Meiss F, Möbes M, Welzel J, Schilling B, Ziller F, Kaatz M, Kreuter A, Sindrilaru A, Dippel E, Sachse M, Weishaupt C, Hüning S, Heinzerling L, Loquai C, Schley G, Gambichler T, Löffler H, Grabbe S, Schultz E, Devereux N, Hassel JC, Simon JC, Raap U, Assaf C, Klemke CD, Sunderkötter C, Hofmann SC, Wenk S, Tronnier M, Thies S, Heppt MV, Eggermont A, Schulze HJ, Zouboulis CC, Tüting T, Bauer AT, Schneider SW, Gebhardt C. Improved survival of advanced melanoma patients receiving immunotherapy with concomitant antithrombotic therapy - A multicenter study on 2419 patients from the prospective skin cancer registry ADOReg. Eur J Cancer. 2024 Nov 30;214:115159. doi: 10.1016/j.ejca.2024.115159. Epub ahead of print. PMID: 39642845.

Weihrauch T, Melo RCN, Gray N, Voehringer D, Weller PF, Raap U. Eosinophil extracellular vesicles and DNA traps in allergic inflammation. Front Allergy. 2024 Aug 1;5:1448007. doi: 10.3389/falgy.2024.1448007. PMID: 39148911 ; PMCID: PMC11324581. 

Weihrauch T, Gray N, Wiebe D, Schmelz M, Limberg M.M^†, Raap, U^†. TRPV1 Channel in Human Eosinophils: Functional Expression and Inflammatory Modulation. Int. J. Mol. Sci. 2024, 25(3):1922. https://doi.org10.3390/ijms25031922; ^†equal contribution

Gray N, Wiebe D, Weihrauch T, Raap U, Limberg MM. Density Gradient Centrifugation-Independent Purification of Human Basophils. Curr Protoc. 2024 Feb;4(2):e991. doi: 10.1002/cpz1.991. PMID: 38358026.

Kotnik N, Langner A, Meyer NH, Pas HH, Gibbs BF, Meijer JM, Diercks GFH, Horváth B, Raap U. Infiltration analysis of eosinophils and basophils and co-expression of CD69, CD63, IL-31 and IgE in patients with bullous and non-bullous pemphigoid. J Eur Acad Dermatol Venereol. 2023 Oct 31. doi: 10.1111/jdv.19593. Epub ahead of print. PMID: 37907267.

2023

Stahl LS, Wolters AC, Kautz O, Patsinakidis N, Raap U. Flammenfiguren – Eosinophile, die die Haut in Brand setzen [Flame figures-eosinophils setting the skin on fire]. Dermatologie (Heidelb). 2023 Sep 20. German. doi: 10.1007/s00105-023-05216-4. Epub ahead of print. PMID: 37728797.

Augustin M, Zeidler C, von Kiedrowski R, Metz M, Darsow U, Raap U, Legat FJ, Sebastian M, Weisshaar E, Ständer S. Indication for systemic therapy in chronic prurigo: Annotated checklist for practice. J Dtsch Dermatol Ges. 2023 Sep 18. doi: 10.1111/ddg.15152. Epub ahead of print. PMID: 37723931.

Moñino-Romero S, Kolkhir P, Szépfalusi Z, Schoepke N, Metz M, Asero R, Ferrer M, Gimenez-Arnau A, Grattan CEH, Jakob T, Konstantinou GN, Raap U, Staubach P, Zhang K, Bindslev-Jensen C, Daschner A, Kinaciyan T, Makris M, Marrouche N, Schmid-Grendelmeier P, Sussman G, Toubi E, Maurer M, Altrichter S. (2023) In chronic spontaneous urticaria soluble FcεRI is elevated and linked to atopy and chronic inducible urticaria. Clin Transl Allergy. 2023 Jul;13(7):e12272. doi: 10.1002/clt2.12272. PMID: 37488737; PMCID: PMC10314276.

Augustin M, Zeidler C, von Kiedrowski R, Metz M, Darsow U, Raap U, Legat FJ, Sebastian M, Weisshaar E, Ständer S. (2023) [Indikation zur Systemtherapie bei chronischer Prurigo: Kommentierte Checkliste für die Praxis]. J Dtsch Dermatol Ges. 2023 Jul;21(7):822-824. German. doi: 10.1111/ddg.15152_g. PMID: 37427739.

Limberg MM, Weihrauch T (joint 1st), Gray N, Ernst N, Hartmann K, Raap U. (2023) Eosinophils, Basophils, and Neutrophils in Bullous Pemphigoid. Biomolecules 13, 1019. doi.org/10.3390/biom13071019.

Zeidler C, Raap U, Witte F, Ständer S. (2023) "Clinical aspects and management of chronic itch". J Allergy Clin Immunol. 2023 May 11:S0091-6749(23)00569-9. doi: 10.1016/j.jaci.2023.04.018. Online ahead of print.PMID: 37178730 Review.

Raap U^†, Limberg MM^†, Kridin K, Ludwig RJ. (2023) Pruritus Is Associated with an Increased Risk for the Diagnosis of Autoimmune Skin Blistering Diseases: A Propensity-Matched Global Study. Biomolecules 2023 Mar 6;13(3):485. doi: 10.3390/biom13030485 PMID: 36979421.^†equal contribution

Weihrauch T, Limberg MM, Gray N, Schmelz M, Raap U. (2023) Neurotrophins: Neuroimmune Interactions in Human Atopic Diseases. International Journal of Molecular Sciences. 2023; 24(7):6105. https://doi.org/10.3390/ijms24076105.

Brans R, Schröder-Kraft C, Bauer A, Weisshaar E, Skudlik C, Geier J; IVDK. (2023) Contact sensitizations in massage therapists with occupational contact dermatitis: Patch test data of the Information Network of Departments of Dermatology, 2008-2020. Contact Dermatitis. 2023 Jan;88(1):43-53. doi: 10.1111/cod.14218. Epub 2022 Oct 4. PMID: 36088572.

2022

Gray N, Limberg MM, Wiebe D, Weihrauch T, Langner A, Brandt N, Bräuer AU, Raap U. (2022) Differential Upregulation and Functional Activity of S1PR1 in Human Peripheral Blood Basophils of Atopic Patients. Int. J. Mol. Sci. 2022, 23(24), 16117; https://doi.org/10.3390/ijms232416117 (registering DOI).

Papakonstantinou E, Fischer J, Limberg MM, Diercks GFH, Horvath B, Raap U. (2022) [Eosinophilic dermatoses] Dermatologie (Heidelb). 2022 Nov 15. doi: 10.1007/s00105-022-05071-9. Online ahead of print.

Worm M, Alexiou A, Bauer A, Treudler R, Wurpts G, Dickel H, Buhl T, Müller S, Jung A, Brehler R, Fluhr J, Klimek L, Mülleneisen N, Pfützner W, Raap U, Roeseler S, Schuh S, Timmermann H, Heine G, Wedi B, Brockow K. (2022) Management of suspected and confirmed COVID-19 (SARS-CoV-2) vaccine hypersensitivity. Allergy. 2022 Nov;77(11):3426-3434. doi: 10.1111/all.15414. Epub 2022 Jul 4. PMID: 35722723.

Ständer S, Zeidler C, Augustin M, Darsow U, Kremer AE, Legat FJ, Koschmieder S, Kupfer J, Mettang T, Metz M, Nast A, Raap U, Schneider G, Ständer H, Streit M, Schut C, Weisshaar E (2022) S2k guideline: Diagnosis and treatment of chronic pruritus. J Dtsch Dermatol Ges. 2022 Oct;20(10):1387-1402. doi: 10.1111/ddg.14830. PMID: 36252071.

Ständer S, Zeidler C, Augustin M, Darsow U, Kremer AE, Legat FJ, Koschmieder S, Kupfer J, Mettang T, Metz M, Nast A, Raap U, Schneider G, Ständer H, Streit M, Schut C, Weisshaar E. (2022) S2k Leitlinie: Diagnostik und Therapie des chronischen Pruritus. J Dtsch Dermatol Ges. 2022 Oct;20(10):1386-1402. doi: 10.1111/ddg.14830_g. PMID: 36252075.

Brans R, Schröder-Kraft C, Bauer A, Weisshaar E, Skudlik C, Geier J, IVDK (2022) Contact sensitizations in massage therapists with occupational contact dermatitis: patch test data of the Information Network of Departments of Dermatology (IVDK), 2008 to 2020. Contact Dermatitis. 2022 Sep 11.doi: 10.1111/cod.14218. Online ahead of print.

Metz M, Raap U (2022) [Novel aspects of the current guideline for chronic pruritus] Review Dermatologie (Heidelb). 2022 Aug;73(8):609-612. doi: 10.1007/s00105-022-05015-3. Epub 2022 Jun 9.

Asano K, Tamari M, Zuberbier T, Yasudo H, Morita H, Fujieda S, Nakamura Y, Traidl S, Hamelmann E, Raap U, Babina M, Nagase H, Okano M, Katoh N, Ebisawa M, Renz H, Izuhara K, Worm M (2022) Diversities of allergic pathologies and their modifiers: Report from the second DGAKI-JSA meeting. Allergol Int. 2022 Jul;71(3):310-317. doi: 10.1016/j.alit.2022.05.003. Epub 2022 Jun 2.

Worm M, Alexiou A, Bauer A, Treudler R, Wurpts G, Dickel H, Buhl T, Müller S, Jung A, Brehler R, Fluhr J, Klimek L, Mülleneisen N, Pfützner W, Raap U, Roeseler S, Schuh S, Timmermann H, Heine G, Wedi B, Brockow K. Management of suspected and confirmed COVID-19 (SARS-CoV-2) vaccine hypersensitivity. Allergy. 2022 Jun 20. doi: 10.1111/all.15414. Online ahead of print.PMID:35722723.

De Prins L, Raap U, Mueller T, Schmid-Grendelmeier P, Haase CH, Backer V, Fokkens W, Benoist LB, Prokopakis E, Hopkins C, Claeys N, Teeling T, Cypers L, Cools L, Bjermer LH, Diamant Z, Wahn U, Scadding G, Bachert C, Patel SR, Van Staeyen E, Hellings P. (2022) White Paper on European Patient Needs and Suggestions on Chronic Type 2 Inflammation of Airways and Skin by EUFOREA. Front Allergy. 2022 Jun 2;3:889221. doi: 10.3389/falgy.2022.889221. eCollection 2022.PMID:35769567.

Asano K, Tamari M, Zuberbier T, Yasudo H, Morita H, Fujieda S, Nakamura Y, Traidl S, Hamelmann E, Raap U, Babina M, Nagase H, Okano M, Katoh N, Ebisawa M, Renz H, Izuhara K, Worm M. (2022) Diversities of allergic pathologies and their modifiers: Report from the second DGAKI-JSA meeting. Allergol Int. 2022 Jun 2:S1323-8930(22)00044-2. doi: 10.1016/j.alit.2022.05.003. Online ahead of print. PMID: 35662539.

Oláh P, Szlávicz E, Kuchner M, Nemmer J, Zeeuwen P, Lefèvre-Utile A, Fyhrquist N, Prast-Nielsen S, Skoog T, Serra A, Rodríguez E, Raap U, Meller S, Gyulai R, Hupé P, Kere J, Levi-Schaffer F, Tsoka S, Alexander H, Nestle FO, Schröder JM, Weidinger S, van den Bogaard E, Soumelis V, Greco D, Barker J, Lauerma A, Ranki A, Andersson B, Alenius H, Homey B.Oláh P. (2022) Influence of FLG loss-of-function mutations in host-microbe interactions during atopic skin inflammation. J Dermatol Sci. 2022 Apr 15:S0923-1811(22)00097-4. doi: 10.1016/j.jdermsci.2022.04.007. Online ahead of print.J Dermatol Sci. 2022. PMID: 35537882.

Noubissi Nzeteu GA, Schlichtner S, David S, Ruppenstein A, Fasler-Kan E, Raap U, Sumbayev VV, Gibbs BF, Meyer NH.Noubissi Nzeteu GA, et al. (2022) Macrophage Differentiation and Polarization Regulate the Release of the Immune Checkpoint Protein V-Domain Ig Suppressor of T Cell Activation. Front Immunol. 2022 May 11;13:837097. doi: 10.3389/fimmu.2022.837097. eCollection 2022.Front Immunol. 2022. PMID: 35634346 Free PMC article.

Worm M, Raap U. (2022) [Food allergy: a diagnostic and therapeutic challenge]. Hautarzt. 2022 Mar;73(3):177-178. doi: 10.1007/s00105-022-04950-5. Epub 2022 Mar 1. PMID: 35230456.

Eberlein B, Mathes S, Fischer J, Darsow U, Biedermann T, Brockow K. (2022) Do basophil activation tests help elucidate allergic reactions to the ingredients in COVID-19 vaccines? Allergy. 2022, accepted.

Chakrapani N, Fischer J, Swiontek K, Codreanu-Morel F, Hannachi, Morisset M, Mugemana C, Bulaev D, Blank S, Bindslev-Jensen C, Biedermann T, Ollert M, Hilger C. (2022) α-Gal present on both glycolipids and glycoproteins contributes to the immune response in meat allergic patients. J Allergy Clin Immunol. 2022, accepted.

Fischer J, Reepschläger T, Schricker T, Raap U. (2022) [Alpha-gal syndrome: Overview of clinical presentation and pathophysiology]. Hautarzt. 2022 Mar;73(3):195-200. doi: 10.1007/s00105-022-04943-4. Epub 2022 Feb 4. PMID: 35119482.

Schlichtner S, Yasinska IM, Ruggiero S, Berger SM, Aliu N, Prunk M, Kos J, Meyer NH, Gibbs BF, Fasler-Kan E, Sumbayev VV. (2022) Expression of the Immune Checkpoint Protein VISTA Is Differentially Regulated by the TGF-β1 - Smad3 Signaling Pathway in Rapidly Proliferating Human Cells and T Lymphocytes. Front Med (Lausanne). 2022 Feb 10;9:790995. doi: 10.3389/fmed.2022.790995. eCollection 2022.

Stenger F, Seidel P, Schricker T, Volc S, Fischer J. (2022) Could cat flea bites contribute to alpha-gal serum IgE levels in humans? J Investig Allergol Clin Immunol. 2022 Jan 24:0. doi: 10.18176/jiaci.0784. Epub ahead of print. PMID: 35088764.

Geier J, Ballmer-Weber B, Buhl T, Rieker-Schwienbacher J, Mahler V, Dickel H, Schubert S; IVDK. Is benzyl alcohol a significant contact sensitizer? J Eur Acad Dermatol Venereol. 2022 Jan 26. doi: 10.1111/jdv.17968. Online ahead of print. PMID: 35080274.

Gray N, Limberg MM, Bräuer AU, Raap U. (2022) Novel functions of S1P in chronic itchy and inflammatory skin diseases. J Eur Acad Dermatol Venereol. 2022 Mar;36(3):365-372. doi: 10.1111/jdv.17764. Epub 2021 Nov 12.

2021

Brockow K, Mathes S, Fischer J, Volc S, Darsow U, Eberlein B, Biedermann T. (2021) Experience with polyethylene glycol allergy-guided risk management for COVID-19 vaccine anaphylaxis. Allergy. 2021 Nov 22. doi: 10.1111/all.15183. Epub ahead of print. PMID: 34806775.

Kellner C, Lutz S, Oberg HH, Wesch D, Otte A, Diemer KJ, Wilcken H, Bauerschlag D, Glüer CC, Wichmann C, Kabelitz D, Leusen JHW, Klausz K, Humpe A, Gramatzki M, Peipp M. (2021) Tumor cell lysis and synergistically enhanced antibody-dependent cell-mediated cytotoxicity by NKG2D engagement with a bispecific immunoligand targeting the HER2 antigen. Biol Chem. 2021 Oct 29. doi: 10.1515/hsz-2021-0229. Online ahead of print.PMID: 34717050.

Otte A, Müller HL. (2021) Childhood-onset Craniopharyngioma. J Clin Endocrinol Metab. 2021 Sep 27;106(10):e3820-e3836. doi: 10.1210/clinem/dgab397.PMID: 34086900 Review.

Burger R, Otte A, Brdon J, Peipp M, Gramatzki M. (2021) Dual intracellular targeting by ruxolitinib and the Mcl-1 inhibitor S63845 in interleukin-6-dependent myeloma cells blocks. Haematologica. 2021 Sep 1;106(9):2507-2510. doi: 10.3324/haematol. 2020.276865.PMID: 33882638.

Traidl S, Werfel T, Ruëff F, Simon D, Lang C, Geier J; IVDK. (2021) Patch test results in patients with suspected contact allergy to shoes: Retrospective IVDK data analysis 2009-2018. Contact Dermatitis. 2021 Sep;85(3):297-306. doi: 10.1111/cod.13868 Epub 2021 May 11. PMID: 33882155.

Schlichtner S, Meyer NH, Yasinska IM, Aliu N, Berger SM, Gibbs BF, Fasler-Kan E, Sumbayev VV. (2021) Functional role of galectin-9 in directing human innate immune reactions to Gram-negative bacteria and T cell apoptosis. Int Immunopharmacol. 2021 Nov;100:108155. doi: 10.1016/j.intimp.2021.108155. Epub 2021 Sep 17.

Peters F, Rahn S, Mengel M, Scharfenberg F, Otte A, Koudelka T, Wagner EF, Wunderlich FT, Haase M, Naumann R, Tholey A, Becker-Pauly C. (2021) Syndecan-1 shedding by meprin β impairs keratinocyte adhesion and differentiation in hyperkeratosis. Matrix Biol. 2021 Aug;102:37-69. doi: 10.1016/j.matbio.2021.08.002. Epub 2021 Sep 8.PMID: 34508852.

Gubensäk N, Schrank E, Hartlmüller C, Göbl C, Falsone FS, Becker W, Wagner GE, Pulido S, Meyer NH, Pavkov-Keller T, Madl T, Reidl J, Zangger K. (2021) Structural and DNA-binding properties of the cytoplasmic domain of Vibrio cholerae transcription factor ToxR. J Biol Chem. 2021 Oct;297(4):101167. doi: 10.1016/j.jbc.2021.101167]. Epub 2021 Sep 4.

Boekhoff S, Bison B, Genzel D, Eveslage M, Otte A, Friedrich C, Flitsch J, Müller HL. (2021) Cerebral Infarction in Childhood-Onset Craniopharyngioma Patients: Results of KRANIOPHARYNGEOM 2007. Front Oncol. 2021 Jul 14;11:698150. doi: 10.3389/fonc.2021.698150. eCollection 2021.PMID: 34336685.

Klausz K, Cieker M, Kellner C, Rösner T, Otte A, Krohn S, Lux A, Nimmerjahn F, Valerius T, Gramatzki M, Peipp M. (2021) Fc-engineering significantly improves the recruitment of immune effector cells by anti-ICAM-1 antibody MSH-TP15 for myeloma therapy. Haematologica. 2021 Jul 1;106(7):1857-1866. doi: 10.3324/haematol.2020.251371.PMID: 32499243.

Teo Hansen Selnø A, Schlichtner S, Yasinska IM, Sakhnevych SS, Fiedler W, Wellbrock J, Berger SM, Klenova E, Gibbs BF, Fasler-Kan E, Sumbayev VV. (2021) High Mobility Group Box 1 (HMGB1) Induces Toll-Like Receptor 4-Mediated Production of the Immunosuppressive Protein Galectin-9 in Human Cancer Cells. Front Immunol. 2021 Jun 21;12:675731. doi: 10.3389/fimmu.2021.675731. eCollection 2021. PMID: 34234778.

Lamberts A, Kotnik N, Diercks GFH, Meijer JM, Di Zenzo G, Pas HH, Jonkman MF, Gibbs BF, Raap U, Horváth B. (2021) IgE autoantibodies in serum and skin of non-bullous and bullous pemphigoid patients. J Eur Acad Dermatol Venereol. 2021 Apr;35(4):973-980. doi: 10.1111/jdv.16996. Epub 2020 Nov 17. PMID: 33058320.

Ruppenstein A, Limberg MM, Loser K, Kremer AE, Homey B, Raap U (2021) Involvement of Neuro-Immune Interactions in Pruritus With Special Focus on Receptor Expressions. Front. Med., 18 February 2021.doi.org/10.3389/fmed.2021.627985.

Nemmer JM, Kuchner M, Datsi A, Oláh P, Julia V, Raap U, Homey B. (2021) Interleukin-31 Signaling Bridges the Gap Between Immune Cells, the Nervous System and Epithelial Tissues. Review Front Med (Lausanne) . 2021 Feb 10;8:639097.doi: 10.3389/fmed.2021.639097. eCollection 2021.

Geier J, Schubert S, Schnuch A, Szliska C, Weisshaar E, Kränke B, Werfel T, Ruëff F, Schröder-Kraft C, Buhl T. (2021) A negative breakdown test in a fragrance mix I-positive patient does not rule out contact allergy to its fragrance constituents. Contact Dermatitis. 2021 Feb 3.doi: 10.1111/cod.13803. Online ahead of print.

Renz H, Bachert C, Berek C, Hamelmann E, Levi-Schaffer F, Raap U, Simon HU, Ploetz S, Taube C, Valent P, Voehringer D, Werfel T, Zhang N, Ring J.Harald R. (2021) Physiology and Pathology of Eosinophils: Recent Developments. Scand J Immunol. 2021 Feb 23:e13032. doi: 10.1111/sji.13032. Online ahead of print.

Welzel J, Breuer G, Geilen C C, Raap U, Schley G, Schultz E, Schwarz S, Stadler R, Thieme D, Zouboulis C C (2021) How to Become a University Hospital? New Ways of Studying Medicine in Germany. Akt. Dermatol 2021; 47: 27-34 DOI 10.1055/a-1262-2073 ISSN 0340-2541.

Zouboulis C C, Geilen C C, Grunewald S, Kauczok C, Raap U, Sander C, Sárdy M, Welzel J. (2021) Structure oft he Dermatology Departments and Teaching in Dermatology at the New Universities in Germany. Akt Dermatol 2021; 47: 35-42 DOI 10.1055/a-1262-2086. ISSN 0340-2541.

Worm M, Bauer A, Wedi B, Treudler R, Pfuetzner W, Brockow K, Buhl T, Zuberbier T, Fluhr J, Wurpts G, Klimek L, Jacob T, Merk HF, Mülleneisen N, Roeseler S, Dickel H, Raap U, Kleine-Tebbe J. (2021) Practical recommendations for the allergological risk assessment of the COVID-19 vaccination - a harmonized statement of allergy centers in Germany. Allergol Select. 2021 Jan 26;5:72-76. doi: 10.5414/ALX02225E. eCollection 2021.

Duderstadt S, Raap U, Patsinakidis N (2021) Rapid therapeutic response of palmoplantar pustulosis under biologic treatment with guselkumab. Dermatol Ther. 2021 Jan 21;e14792. doi: 10.1111/dth.14792. Online ahead of print.

Kleiner S, Rüdrich U, Gehring M, Loser K, Eiz-Vesper B, Noubissi Nzeteu G, Patsinakidis N, Meyer NH, Gibbs BF, Raap U (2021) Human basophils release the anti-inflammatory cytokine IL-10 following stimulation with α-melanocyte-stimulating hormone. J Allergy Clin Immunol. 2021 Jan 15;S0091-6749(21)00009-9.doi: 10.1016/j.jaci.2020.12.645. Online ahead of print.

2020

Selnø ATH, Schlichtner S, Yasinska IM, Sakhnevych SS, Fiedler W, Wellbrock J, Klenova E, Pavlova L, Gibbs BF, Degen M, Schnyder I, Aliu N, Berger SM, Fasler-Kan E, Sumbayev VV. (2020)Transforming growth factor beta type 1 (TGF-β) and hypoxia-inducible factor 1 (HIF-1) transcription complex as master regulators of the immunosuppressive protein galectin-9 expression in human cancer and embryonic cells. Aging (Albany NY). 2020 Dec 8;12(23):23478-23496. doi:10.18632/aging.202343.

Yasinska IM, Meyer NH, Schlichtner S, Hussain R, Siligardi G, Casely-Hayford M, Fiedler W, Wellbrock J, Desmet C, Calzolai L, Varani L, Berger SM, Raap U, Gibbs BF, Fasler-Kann E, Sumbayev VV. (2020) Ligand-Receptor Interactions of Galectin-9 and VISTA Suppress Human T Lymphocyte Cytotoxic Activity. Front. Immunol., 20 November 2020 | doi.org/10.3389/fimmu.2020.580557.

Patsinakidis N, Meyer NH, Raap U. (2020) [Psoriasis] MMW Fortschr Med. Nov;162(Suppl 3):43-50. doi: 10.1007/s15006-020-1458-8.

Lamberts A, Kotnik N, Diercks GFH, Meijer JM, Di Zenzo G, Pas HH, Jonkman MF, Gibbs BF, Raap U, Horváth B. (2020) IgE autoantibodies in serum and skin of nonbullous and bullous pemphigoid patients. J Eur Acad Dermatol Venereol 2020 Oct 15. doi: 10.1111/jdv.16996. Online ahead of print.

Köthe A, Patsinakidis N, Raap U. Fixes bullöses Arzneimittelexanthem. Akt Dermatol 2020; 46:344-350.

Kotnik N, El-Sourani N, Raap U, Raab HR, Bockhorn M, Meyer H, Troja A. (2020) Expression of MicroRNA in Locoregional Recurrent Rectal Cancer. Anticancer Res. 2020 May;40(5):2947-2953. doi: 10.21873/anticanres.14273.PMID: 32366447

Guseva D, Rüdrich U, Kotnik N, Gehring M, Patsinakidis N, Agelopoulos K, Ständer S, Homey B, Kapp A, Gibbs BF, Ponimaskin E, Raap U. (2020) Neuronal branching of sensory neurons is associated with BDNF-positive eosinophils in atopic dermatitis. Clin Exp Allergy. 2020 May;50(5):577-584. doi: 10.1111/cea.13560. Epub 2020 Feb 4. PubMed PMID: 31925827.

Papakonstantinou E, Raap U (2020). Herpes Zoster Schwere Komplikationen verhindern. Der Deutsche Dermatologe 2020; 68 (2): 114-122.

Schnuch A, Schubert S, Lessmann H, Geier J; IVDK. (2020). The methylisothiazolinone epidemic goes along with changing patients' characteristics - After cosmetics, industrial applications are the focus. Contact Dermatitis. 2020 Feb;82(2):87-93. doi: 10.1111/cod.13414. Epub 2019 Nov 17.

2019

Gibbs BF, Patsinakidis N, Raap U. (2019) Role of the Pruritic Cytokine IL-31 in Autoimmune Skin Diseases. Front Immunol. Jun 21;10:1383. doi: 10.3389/fimmu.2019.01383. eCollection 2019. Review.

Schoepke N, Asero R, Ellrich A, Ferrer M, Gimenez-Arnau A, Grattan CEH, Jakob T, Konstantinou GN, Raap U, Skov PS, Staubach P, Kromminga A, Zhang K, Bindslev-Jensen C, Daschner A, Kinaciyan T, Knol EF, Makris M, Marrouche N, Schmid-Grendelmeier P, Sussman G, Toubi E, Church MK, Maurer M. (2019) Biomarkers and clinical characteristics of autoimmune chronic spontaneous urticaria (aiCSU): Results of the PURIST Study. Allergy.  Jun 22. doi: 10.1111/all.13949. [Epub ahead of print]

Maurer M, Raap U, Staubach P, Richter-Huhn G, Bauer A, Oppel EM, Hillen U, Baeumer D, Reinhardt M, Chapman-Rothe N (2019) Antihistamine-resistant chronic spontaneous urticaria: 1-year data from the AWARE study. Clin Exp Allergy. 49(5):655-662. doi: 10.1111/cea.13309

Bauer A, Geier J, Schreiber S, Schubert S; IVDK.Contact sensitization to plants of the Compositae family: Data of the Information Network of Departments of Dermatology (IVDK) from 2007 to 2016 (2019) Contact Dermatitis. 80(4):222-227. doi: 10.1111/cod.13169

Yasinska IM, Calzolai L, Raap U, Hussain R, Siligardi G, Sumbayev VV, Gibbs BF (2019) Targeting of Basophil and Mast Cell Pro-Allergic Reactivity Using Functionalised Gold Nanoparticles. Front Pharmacol. 29;10:333. doi: 10.3389/fphar.2019.00333.

Papakonstantinou E, Limberg MM (joint 1st ), Gehring M, Kotnik N, Kapp A, Gibbs BF, Raap U (2019) Neurological Disorders are Associated with Bullous Pemphigoid. J Eur Acad Dermatol Venereol. 33(5):925-929. doi: 10.1111/jdv.15444

Tsianakas A, Zeidler C, Riepe C, Borowski M, Forner C, Gerss J, Metz M, Staubach P, Raap U, Kaatz M, Urban M, Luger TA, Ständer S (2019) Aprepitant in Anti-histamine-refractory Chronic Nodular Prurigo: A Multicentre, Randomized, Double-blind, Placebo-controlled, Cross-over, Phase-II trial (APREPRU). Acta Derm Venereol. doi: 10.2340/00015555-3120.

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