Prof. Dr. Ralf Rabus


Fax: +49-(0)441-798-3404

Universität Oldenburg, Campus Wechloy
Raum: W03 0-092
Carl-von-Ossietzky-Straße 9-11
26111 Oldenburg


Curriculum vitae

Cover illustration for Proteomics (issue 18, 2022) based on the study "Transcriptome–proteome compendium of the Antarctic krill (Euphausia superba): Metabolic potential and repertoire of hydrolytic enzymes"

Description unavailable

Cover illustration for Proteomics (issue 22, 2017) based on the study "Impact of Extraction Methods on the Detectable Protein Complement of Metaproteomic Analyses of Marine Sediments"


Cover illustration for Proteomics (issue 22, 2016) based on the study "Differential proteomic analysis of the metabolic network of the marine sulfate-reducer Desulfobacterium autotrophicum HRM2"

Cover illustration for the Journal of Molecular Microbiology and Biotechnology (issue 26(1-3), 2016) for special issue on Anaerobic Hydrocarbon Degradation edited by R. Rabus.

Cover illustration for Proteomics (issue 18-19, 2013) for special issue on Environmental Microbial Proteomics edited by R. Rabus.


Publication Record (Publications, Reviews or Book Chapters)


Research publications

Kalvelage J, Wöhlbrand L, Senkler J, Schumacher J, Ditz N, Bischof K, Winklhofer M, Klingl A, Braun H-P, and Rabus R (2024)
Conspicuous chloroplast with light harvesting photosystem I/II megacmplex in marine Prorocentrum cordatum. Plant Physiol 2024 Feb 8:kiae052 doi: 10.1093/plphys/kiae052

Möller L, Vainstein Y, Meyer B, Neidhardt J, Eren AM, Sohn K, and Rabus R (2024)
Rich microbial and depolymerising diversity in Antarctic krill gut. Microbiol Spectr 2024 Mar 11:e0403523. doi: 10.1128/spectrum.04035-23

Clausen U, Vital ST, Lambertus P, Gehler M, Scheve S, Wöhlbrand L, and Rabus R (2024)
Catabolic network of the fermentative gut Bacterium Phocaeicola vulgatus (phylum Bacteriodetes) from a physiologic-proteomic perspective. Microbiol Physiol doi: 10.1159/000536327

Pucelik S, Becker M, Heyber S, Wöhlbrand L, Rabus R, Jahn D, and Gärtig E (2024)
The blue light-dependent LOV-protein LdaP of Dinoroseobacter shibae acts as antirepressor of the PpsR repressor, regulating photosynthetic gene cluster expression. Front Microbiol 202 Feb 7:15:1351297 doi: 10.3389/fmicb.2024.1351297



Research publications

Dougan KE, Deng, Z-L, Wöhlbrand L, Reuse C, Bunk B, Chen Y, Hertlich J, Hiller K, John U, Kalvelage J, Mansky J, Neumann-Schaal M, Overmann J, Petersen J, Sanchez-Garcia S, Schmidt-Hohagen K, Shah S, Sprröer C, Sztajer H, Wang H, Bhattacharya D, Rabus R, Jahn D, Chan CX, and Wagner-Döbler I (2023)
Multi-omics analysis reveals the molecular response to heat stress in a "red tide" dinoflagellate. Genome Biol 24(1):265 doi: 10.1186/s13059-023-03107-4.

Buschen R, Lambertus P, Scheve S, Horst S, Song F, Wöhlbrand L, Neidthardt J, Winklhofer M, Wagner T,  and Rabus R (2023)
Sensitive and selective phenol sensing in denitrifying Aromatoleum aromaticum EbN1T. Microbiol Spectr 2023 Oct 12:e0210023. doi: 10.1128/spectrum.02100-23

Kalvelage J, Wöhlbrand L, Schoon R-A, Zink F-M, Correll C, Senkler J, Eubel H, Hoppenrath M, Rhiel E, Braun H-P, Winklhofer M, Klingl A, and Rabus R (2023)
The enigmatic nucleus of the marine dinoflagellate Prorocentrum cordatum. mSphere24;8(4):e0003823. doi: 10.1128/msphere.00038-23


Reviews or Book Chapters

Becker P, Wünsch D, Wöhlbrand L, Neumann-Schaal M, Schomburg D, and Rabus R (2023)
The catabolic network of Aromatoleum aromaticum EbN1T. Microb Physiol doi: 10.1159/000534425



Research publications

Becker P, Kirstein S, Wünsch D, Koblitz J, Buschen R, Wöhlbrand L, Bunk B, Hinrichs C, Kaltenhäuser S, Lehmann J, Martens G, Ripken BK, Riemer SA, Stoltenberg P, Thies D, Trautwein K, Wenzel EV, Schomburg I; Winklhofer M, Schomburg D, Neumann-Schaal M, and Rabus R (2022)
Systems biology of aromatic compound catabolism in facultative anaerobic Aromatoleum aromaticum EbN1T . mSystems doi: 10.1128/msystems.00685-22

Möller L, Vainstein Y, Wöhlbrand L, Dörries M, Meyer B, Sohn K and Rabus R (2022)
Transcriptome-proteome compendium of the Antarctic krill (Euphausia superba): Metabolic potential and repertoire of hydrolytic enzymes. Proteomics doi: 10.1002/pmic.202100404

Westermann M, Hoischen C, Wöhlbrand L, Rabus R and Rhile E (2022)
Light and prey influence the abundance of two rhodopsins in the dinoflagellate Ohyrrhis marina. Protoplasma doi: 10.1007/s00709-022-01795-6

Becker P, Döhmann A, Wöhlbrand L, Thies D, Hinrichs C, Buschen R, Wünsch D, Neumann-Schaal M, Schomburg D, Winklhofer M, Reinhardt R, and Rabus R (2022)
Complex and flexible catabolism in Aromatoleum aromaticum pCyN1. Environ Microbiol doi: 10.1111/1462-2920.16074

Gross I, Brandt N, Vonk D, Köper F, Wöhlbrand L, Rabus R, Witt M, Heep A, Plösch T, Hipp MS and Bräuer AU (2022)
Plasticity-related gene 5 is expressed in late phase of neurodifferentitation after neuronal cell-fate determination. Front Cell Neurosci doi: 10.3389/fncel.2022.797588


Research publications

Feller FM, Wöhlbrand L, Holter J, Schnaars V, Elsner L, Mohn WM, Rabus R and Philipp B (2021)
Proteome, bioinformatic and functional analyses reveal a distinct and conserved metabolic pathway for bile salt degradation in the Sphingomonadaceae. Appl Environ Microbiol doi: 10.1128/AEM.00987-21

Vagts J, Kalvelage K, Weiten A, Buschen R, Gutsch J, Scheve S, Wöhlbrand L, Diener S, Wilkes H, Winklhofer M and Rabus R (2021)
Responsiveness of Aromatoleum aromaticum EbN1T to lignin-derived phenylpropanoids. Appl Environ Microbiol doi: 10.1128/AEM.03140-20

Schnaars V, Wöhlbrand L, Scheve S, Hinrichs C, Reinhardt R and Rabus R (2021)
Proteogenomic insigths into the physiology of marine, sulfate-reducing, filamentous Desulfonema limicola and Desulfonema magnum. Microb Physiol doi: 10.1159/000513383

Weiten A, Kalvelage K, Becker P, Reinhardt R, Hurek T, Reinhold-Hurek B and Rabus R (2021)
Complete genomes of the anaerobic degradation specialists Aromatoleum petrolei ToN1 and Aromatoleum bremense PbN1. Microb Physiol doi: 10.1159/000513167

Cakic N, Kopke B, Rabus R and Wilkes H (2021)
Suspect screening and targeted analysis of acyl coenzyme A thioesters in bacterial cultures using a high-resolution tribrid mass spectrometer. Anal Bioanal Chem doi:10.1007/s00216-021-03318-3

Feller MF, Marke G, Drees SL, Wöhlbrand L, Rabus R and Phillipp B (2021)
Substrate inhibition of 5β-Δ4-3-ketosteroid dehydrogenase in Sphingobium sp. strain Chol11 acts as circuit breaker during growth with toxic bile salts. Front Microbiol doi: 10.3389/fmicb.2021.655312

van Strien J, Haupts A, Schulte U, Braun H-P, Cabrera-Orefice A, Choudhar JS, Evers F, Fernandez-Vizarra, Guerrero-Castillo S, Kooij TWA, Páleníková P, Pardo M, Ugalde C, Wittig I, Wöhlbrand L, Brandt U, Arnold S and Huynen MA (2021)
CEDAR, an online resource for the reporting and exploration of complexome profiling data. Biochim Biophys Acta Bioenerg doi: 10.1016/j.bbabio.2021.148411



Research publications

Michas A, Harir M, Lucio M, Vestergaard G, Himmelberg A, Schmitt-Kopplin P, Lueders T, Hatzinikolaou DG, Schlöer A, Rabus R and Schloter M (2020)
Sulfate alters the competition among microbiome members of sediments chronically exposed to asphalt. Front Microbiol 11:556793 doi: 10.3389/fmicb.2020.556793

Wünsch D, Strijkstra A, Wöhlbrand L, Freese HM, Scheve S, Hinrichs C, Trautwein K, Maczka M, Petersen J, Schulz S, Overmann J and Rabus R (2020)
Global response of Phaeobacter inhibens DSM 17395 to deletion of Its 262-kb chromid encoding antibiotic synthesis. Microb Physiol doi: 10.1159/000508591

Mitschke N, Jarling R, Rabus R, Christoffers J and Wilkes H (2020)
Metabolites of the anaerobic degradation of diethyl ether by denitrifying betaproteobacterium strain HxN1. Org Biomol Chem 18(36):7098-7109 doi: 10.1039/d0ob01419b

Heyen S, Scholz-Böttcher BM, Rabus R and Wilkes H (2020)
Method development and validation for the quantification of organic acids in microbial samples using anionic exchange solid-phase extraction and gas chromatography-mass spectrometry. Anal Bioanal Chem doi: 10.1007/s00216-020-02883-3

Rhiel E, Nguyen T, Wöhlbrand L and Rabus R (2020)
A simple protocol for the isolation of proteorhodopsins of the dinoflagellate Oxyrrhis marina. J Basic Microbiol 60(4):351-361 doi: 10.1002/jobm.201900594



Research publications

Vagts J, Weiten A, Scheve S, Kalvelage K, Swirski S, Wöhlbrand L, Neidhardt J, Winklhofer M and Rabus R (2019)
Nanomolar responsiveness of an anaerobic degradation specialist to alkylphenol pollutants. J Bacteriol 202(5):e00595-19 doi: 10.1128/JB.00595-19

Wünsch D, Tautwein K, Scheve S, Hinrichs C, Feenders C, Blasius B, Schomburg D and Rabus R (2019)
Amino acid and sugar catabolism in the marine bacterium Phaeobacter inhibens DSM 17395 from an energetic viewpoint. Appl Environ Microbiol 85(24):e02095-19doi: 10.1128/AEM.02095-19

Christoffers J, Küppers J, Mitschke N, Heyen S, Rabus R and Wilkes H (2019)
Identification of metabolites of the anaerobic degradation of n-hexane by denitrifying bacterium strain HxN1. Chembiochem 21(3):373-380 doi: 10.1002/cbic.201900375

Rabus R, Wöhlbrand L, Thies D, Meyer M, Reinhold-Hurek B and Kämpfer P (2019)
Aromatoleum gen. nov., a novel genus accommodating the phylogenetic lineage including Azoarcus evansii and related species, and proposal of Aromatoleum aromaticum sp. nov., Aromatoleum petrolei sp. nov., Aromatoleum bremense sp. nov., Aromatoleum toluolicum sp. nov. and Aromatoleum diolicum sp. nov. Int J Syst Evol Microbiol 69(4):982-997 doi:10.1099/ijsem.0.003244

Küppers J, Rabus R, Wilkes H and Christoffers J (2019)
Optically active 1-deuterio-1-phenylethane  -  Preparation and proof of enantiopurity. Eur J Org Chem 2619-2634

Küppers J, Becker P, Jarling R, Dörries M, Cakic N, Schmidtmann M, Christoffers J, Rabus R and Wilkes H (2019)
Stereochemical insights into the anaerobic degradation of 4-Iso-propylbenzoyl-CoA in the denitrifying bacterium strain pCyN1. Chemistry 25(18):4722-4731 doi: 10.1002/chem.201805837



Research publications

Schnaars V, Dörries M, Hutchins M, Wöhlbrand L and Rabus R (2018)
What´s the difference? 2D DIGE image analysis by DeCyder versus SameSpots. J Mol Microbiol Biotechnol 28(3):128-136 doi: 10.1159/000494083

Vagts J, Scheve S, Kant M, Wöhlbrand L and Rabus R (2018)
Towards the response threshold of p-hydroxyacetophenone in the denitrifying bacterium "Aromatoleum aromaticum" EbN1. Appl Environ Microbiol 84(18) doi:10.1128/AEM.01018-18

Trautwein K, Hensler M, Wiegmann K, Skorubskaya E, Wöhlbrand L, Wünsch D, Hinrichs C, Feenders C, Müller C, Schell, K, Ruppersberg HS, Vagts J, Koßmehl S, Steinbüchel A, Schmidt-Kopplin P, Wilkes H, Hillebrand H, Blasius B, Schomburg D  and Rabus R (2018)
The marine bacterium Phaeobacter inhibens secures external ammonium by rapid buildup of intracellular nitrogen stocks. FEMS Microbiol 94(10) Ecol doi: 10.1093/femsec/fiy154

Grohmann A, Vainshtein Y, Euchner E, Grumaz C, Bryniok D, Rabus R and Sohn K (2018)
Genetic repertoires of anaerobic microbiomes driving generation of biogas. Biotechnol Biofuels 11:255
doi: 10.1186/s13068-018-1258-x

Rhiel E, Wöhlbrand L and Rabus R (2018)
Lectin-binding and dissociation/reconstitution studies on the trichocysts of the dinoflagellate Oxyrrhis marina Protoplasma 256:459469 doi:10.1007/s00709-018-1308-z

Reviews or Book Chapters

Trautwein K and Rabus R (2018)
Applications of difference gel electrophoresis (DIGE) in the study of microorganisms. Methods Mol Biol 1841:95-112 doi: 10.1007/978-1-4939-8695-8_8

Rabus R and Wilkes H (2018)
Introduction to functional genomics. In: Boll M, de Lorenzo V, Geiger O, Krell T, Lee SY, Lopez D, McGenity T, Prince R, Rojo F, Stams F, Steffan R, Wilkes H (eds.) Handbook of hydrocarbon and lipid microbiology (2nd ed.), Vol 5: Anaerobic utilization of hydrocarbons, oils and lipids,. Springer Nature (in press)

Rabus R and Wilkes H (2018)
Functional genomics of sulfate-reducing bacteria degrading aromatic hydrocarbons. In: Boll M, de Lorenzo V, Geiger O, Krell T, Lee SY, Lopez D, McGenity T, Prince R, Rojo F, Stams F, Steffan R, Wilkes H (eds.) Handbook of hydrocarbon and lipid microbiology (2nd ed.), Vol 5: Anaerobic utilization of hydrocarbons, oils and lipids,. Springer Nature (in press)

Rabus R and Wilkes H (2018)
Functional genomics of denitrifying bacteria degrading aromatic compounds. In: Boll M, de Lorenzo V, Geiger O, Krell T, Lee SY, Lopez D, McGenity T, Prince R, Rojo F, Stams F, Steffan R, Wilkes H (eds.) Handbook of hydrocarbon and lipid microbiology (2nd ed.), Vol 5: Anaerobic utilization of hydrocarbons, oils and lipids,. Springer Nature (in press)

Wilkes H and Rabus R (2018)
Catabolic pathways involved in the anaerobic degradation of saturated hydrocarbons. In: Boll M, de Lorenzo V, Geiger O, Krell T, Lee SY, Lopez D, McGenity T, Prince R, Rojo F, Stams F, Steffan R, Wilkes H (eds.) Handbook of hydrocarbon and lipid microbiology (2nd ed.), Vol 5: Anaerobic utilization of hydrocarbons, oils and lipids,. Springer Nature (in press)



Research publications

Wöhlbrand L, Feenders C, Nachbaur J, Freund H, Engelen B, Wilkes H, Brumsack H-J and Rabus R (2017)
Impact of extraction methods on the detectable protein complement of metaproteomic analyses of marine sediments. Proteomics doi:10.1002/pmic.201700241

Wöhlbrand L, Rabus R, Blasius B and Feenders C (2017)
Influence on nanoLC column and gradient length as well as MS/MS frequency and sample complexity on shotgun protein identification of marine bacteria. J Mol Microbiol Biotechnol 2017;27:199-212

Rhiel E, Wöhlbrand L, Rabus R and Voget S (2017)
Candidates of trichocyst matrix proteins of the dinoflagellate Oxyrrhis marina. Protoplasma doi:10.1007/s00709-017-1148-2

Trautwein K, Feenders C, Hulsch R, Ruppersberg HS, Strijsktra A, Kant M, Vagts J, Wünsch D, Michalke B, Maczka M, Schulz S, Hillebrand H, Blasius B and Rabus R (2017)
Non-Redfied, nutrient synergy, and flexible internal elemental stoichiometry in a marine bacterium. FEMS Microbiol Ecol doi:10.1093/femsec/fix059

Wöhlbrand L, Wemheuer B, Feenders C, Ruppersberg HS, Hinrichs C, Blasius B, Daniel R and Rabus R (2017)
Complementary metaproteomic approaches to assess the bacterioplankton response towards a phytoplankton spring bloom in the southern North Sea. Front Microbiol doi:10.3389/fmicb.2017.00442

Ruppersberg HS, Goebel MR, Kleinert SI, Wünsch D, Trautwein K and Rabus R (2017)
Photometric determination of ammonium and phosphate in seawater medium using a microplate reader. J Mol Microbiol Biotechnol 27(2):73-80



Research publications

Dörries M, Wöhlbrand L, Kube M, Reinhardt R and Rabus R (2016)
Genome and catabolic subproteomes of the marine, nutritionally versatile, sulfate-reducing bacterium Desulfococcus mutlivorans DSM 2059. BMC Genomics 17(1):918

Dörries M, Wöhlbrand L and Rabus R (2016)
Differential proteomic analysis of the metabolic network of the marine sulfate-reducer Desulfobacterium autotrophicum HRM2. Proteomics 16(22):2878-2893

Trautwein K, Will SE, Hulsch R, Maschmann U, Wiegmann K, Hensler M, Michael V, Ruppersberg H, Wünsch D, Feenders C, Neumann-Schaal M, Kaltenhäuser S, Ulbrich M, Schmidt-Hohagen K, Blasius B, Petersen J, Schomburg D and Rabus R (2016)
Native plasmids restrict growth of Phaeobacter inhibens DSM 17395: Energetic costs of plasmids assessed by quantitative physiological analysis. Environ Microbiol 18(12):4817-4829

Strijkstra A, Trautwein K, Roesler C, Feenders C, Danzer D, Riemenschneider U, Blasius B, and Rabus R (2016)
High performance CCD camera system for digitalization of 2D DIGE gels. Proteomics 16(14):1975-1979

Wöhlbrand L, Ruppersberg HS, Feenders C, Blasius B, Braun H-P and Rabus R (2016)
Analysis of membrane protein complexes of the marine sulfate reducer Desulfobacula toluolica Tol2 by 1D Blue Native-PAGE complexome profiling and 2D Blue Native-/SDS-PAGE. Proteomics 16(6):973-988

Bolte P, Bleibaum F, Einwich A, Günther A, Liedvogel M, Heyers D, Depping A, Wöhlbrand L, Rabus R, Janssen-Bienhold U and Mouritsen H (2016)
Localization of the putative magnetoreceptive protein cryptochrome 1b in the retina of migratory birds and homing pigeons. PLoS One 11(3):e0147819

Reviews or Book Chapters

Rabus R, Boll M, Heider J, Meckenstock RU, Buckel W, Einsle O, Ermler U, Golding BT, Gunsalus RP, Kroneck PM, Krüger M, Lueders T, Martins BM, Musat F, Richnow HH, Schink B, Seifert J, Szaleniec M, Treude T, Ullmann GM, Vogt C, von Bergen M and Wilkes H (2016)
Anaerobic microbial degradation of hydrocarbons: from enzymatic reactions to the environment. J Mol Microbiol Biotechnol 26(1-2):5-28

Rabus R, Boll M, Golding BT and Wilkes H (2016)
Anaerobic degradation of p-alkylated benzoates and toluenes. J Mol Microbiol Biotechnol 26(1-2):63-75

Wilkes H, Buckel W, Golding BT and Rabus R (2016)
Metabolism of hydrocarbons in n-alkane-utilizing anaerobic bacteria. J Mol Microbiol Biotechnol 26(1-2):138-151



Research publications

Büsing I, Kant M, Dörries M, Wöhlbrand L and Rabus R (2015)
The predicted σ54-dependent regulator EtpR is essential for expression of genes for anaerobic p-ethylphenol and p-hydroxyacetophenone degradation in "Aromatoleum aromaticum" EbN1. BMC Microbiology 15:251

Büsing I, Höffken HW, Breuer M, Wöhlbrand L, Hauer B and Rabus R (2015)
Molecular genetic and crystal structural analysis of 1-(4-hydroxyphenyl)-ethanol dehydrogenase from "Aromatoleum aromaticum" EbN1. J Mol Microbiol Biotechnol 25:327-339

Jarling R, Kühner S, Basílio Janke E, Gruner A, Drozdowska M, Golding BT, Rabus R and Wilkes H (2015)
Versatile transformations of hydrocarbons in anaerobic bacteria: substrate ranges and regio- and stereo-chemistry of activation reactions. Front Microbiol 6:880


Reviews or Book Chapters

Rabus R, Venceslau SS, Wöhlbrand L, Voordouw G, Wall JD and Pereira IAC (2015)
A post-genomic view of the ecophysiology, catabolism and biotechnological relevance of sulphate-reducing prokaryotes. In Robert K. Poole (Ed): Advances in Microbial Physiology, Vol 66, AMP, UK: Academic Press, pp. 55-321

Rabus R (2015)
Proteomik-Werkzeuge für Mikroorganismen. BioSpektrum 21(5):496-501



Research publications

Lahme S, Trautwein K, Strijkstra A, Dörries M, Wöhlbrand L and Rabus R (2014)
Benzoate medinates the simultaneous repression of anaerobic 4-methylbenzoate and succinate utilization in Magnetospillum sp. strain pMbN1. BMC Microbiology 2014, 14:269  doi:10.1186/s12866-014-0269-4

Strijkstra A, Trautwein K, Karling R, Wöhlbrand L, Dörries M, Reinhardt R, Drozdowska M, Golding BT, Wilkes H and Rabus R (2014)
Anaerobic activation of p-cymene in denitrifying Betaproteobacteria: methyl group hydroxylation versus addition to fumarate. Appl Environ Microbiol, 80(24):7592-603

Wiegmann K, Hensler M, Wöhlbrand L, Ulbrich M, Schomburg D and Rabus R (2014)
Carbohydrate catabolism in Phaeobacter inhibens DSM 17395, member of the marine Roseobacter clade. Appl Environ Microbiol, 80(15):4725-37

Drüppel K, Hensler M, Trautwein K, Koßmehl S, Wöhlbrand L, Schmidt-Hohagen K, Ulbrich M, Bergen N, Meyer-Kolthoff J, Göker M, Klenk HP, Schomburg D and Rabus R (2014)
Pathways and substrate-specific regulation of amino acid degradation in Phaeobacter inhibens DSM 17395 (archetype of the marine Roseobacter clade). Environ Microbiol, 16(1): 218-38

Laaß S, Kleist S, Bill N, Drüppel K, Koßmehl S, Wöhlbrand L, Rabus R, Klein J, Rohde M, Bartsch A, Wittmann C, Schmidt-Hohagen K, Tielen P, Jahn D and Schomburg D (2014)
Gene regulatory and metabolic adaptation processes of Dinoroseobacter shibae DFL12T during oxygen depletion. JBC, 289(19):13219-31


Reviews or Book Chapters

Rabus R (2014)
Fifteen years of physiological proteo(gen)omics with (marine) environmental bacteria. Arch Physiol Biochem, doi:10.3109/13813455.2014.951658.

Rabus R, Trautwein K and Wöhlbrand L (2014)
Towards habitat-oriented systems biology of "Aromatoleum aromaticum" EbN1 : Chemical sensing, catabolic network modulation and growth control in anaerobic aromatic compound degradation. Appl Microbiol Biotechnol, 98(8):3371-88.



Research publications

Koßmehl S, Wöhlbrand L, Drüppel K, Feenders C, Blasius B and Rabus R (2013)
Subcellular protein localization (cell envelope) in Phaeobacter inhibens DSM 17395. Proteomics, 13(18-19): 2743-2760

Zech H, Hensler M, Koßmehl S, Drüppel K , Wöhlbrand L, Trautwein K,  Colby T, Schmidt J, Reinhardt R, Schmidt-Hohagen K , Schomburg D and Rabus R (2013)
Dynamics of amino acid utilization in Phaeobacter inhibens DSM 17395. Proteomics, 13(18-19): 2869-2885

Zech H, Hensler M, Koßmehl S, Drüppel K , Wöhlbrand L, Trautwein K, Hulsch R, Maschmann U, Colby T, Schmidt J, Reinhardt R, Schmidt-Hohagen K , Schomburg D and Rabus R (2013)
Adaptation of Phaeobacter inhibens DSM 17395 to growth with complex nutrients. Proteomics, 13(18-19): 2851-2868

Ebert M, Laaß S, Burghartz M, Petersen J, Koßmehl S, Wöhlbrand L, Rabus R, Wittmann C, Tielen P and Jahn D (2013)
Transposon mutagenesis identified chromosomal and plasmid encoded genes essential for the adaptation of the marine bacterium Dinoroseobacter shibae to anaerobic conditions. J Bacteriol, 195(20): 4769-77

Wöhlbrand L, Jacob J, Kube M, Mussmann M, Jarling R, Beck A, Amann R, Wilkes H, Reinhardt R, Rabus R (2013)
Complete genome, catabolic sub-proteomes and key-metabolites of Desulfobacula toluolica Tol2, a marine, aromatic compound-degrading, sulfate-reducing bacterium. Environ Microbiol, 15(5), 1334–1355


Reviews or Book Chapters

Wöhlbrand L, Trautwein K and Rabus R (2013)
Proteomic tools for environmental microbiology - a roadmap from sample preparation to protein identification and quantification. Proteomics, 13(18-19): 2700-2730

Rabus R (Editor; 2013)
Special issue: Environmental microbial proteomics
Proteomics 13(18-19)



Research publications 

Wolfsheimer S, Hartmann A, Rabus R, Nuel G (2012)
Computing posterior probabilities for score-based alignments using ppALIGN. Stat Appl Gene Mol Biol doi: 10.1515/1544-6115.1702

Trautwein K, Lahme S, Wöhlbrand L, Feenders C, Magelsdorf K, Harder J, Steinbüchel A, Blasius B, Reinhardt R, Rabus R (2012)
Physiological and proteomic adaptation of "Aromatoleum aromaticum" EbN1 to low growth rates in benzoate-limited, anoxic chemostats. J Bacteriol, 194(9):2165-2180

Trautwein K, Wilkes H, Rabus R (2012)
Proteogenomic evidence for beta-oxidation of plant-derived 3-phenylpropanoids in "Aromatoleum aromaticum" EbN1. Proteomics 12, 1402–1413

Lahme S, Eberlein C, Jarling R, Kube M, Boll M, Wilkes H, Reinhardt R, Rabus R (2012)
Anaerobic degradation of 4-methylbenzoate via a specific 4-methylbenzoyl-CoA pathway. Environ Microbiol, 14(5):1118-1132

Trautwein K, Grundmann O, Wöhlbrand L, Eberlein C, Boll M, Rabus R (2012)
Benzoate mediates repression of C4-dicarboxylate utilization in "Aromatoleum aromaticum" EbN1. J Bacteriol 194(2):518-2

Lahme S, Harder J, Rabus R (2012)
Anaerobic degradation of 4-methylbenzoate by a new denitrifying bacterium, strain pMbN1. Appl Environ Microbiol, 78:1606-1610

Jarling R, Sadeghi M, Drozdowska M, Lahme S, Buckel W, Rabus R, Widdel F, Golding BT, Wilkes H (2012)
Stereochemical investigations reveal the mechanism of the bacterial activation of n-alkanes without oxygen. Angew Chem Int Ed, 51:1334-1338

Reviews or Book Chapters

Rabus R (2012)
An overview of 2D DIGE analysis of marine (environmental) bacteria.
In: Cramer R, Westermeier R (Eds), Difference gel electrophoresis (DIGE): Methods and Protocols. Methods in Molecular Biology, Vol. 854. pp. 355-370 Springer Science+Business Media

Kube M, Mitrovic J, Duduk B, Rabus R, Seemüller E (2012)
Current view of Phytoplasma genomes and encoded metabolism
TheScientificWorldJournal, doi: 10.1100/2012/185942


Research publications 

Zech H, Echtermeyer C, Wöhlbrand L, Blasius B, Rabus R (2011)
Biological versus technical variability in 2D DIGE experiments with environmental bacteria. Proteomics 11(16):3380-3389

Rabus R, Jarling R, Lahme S, Kühner S, Heider J, Widdel F, Wilkes H (2011)
Co-metabolic conversion of toluene in anaerobic n-alkane-degrading bacteria. Environ Microbiol 13(9):2576-2586

Reviews or Book Chapters

Halder T, Rabus R (2011)
Dynamik kataboler Netzwerke in Umweltbakterien. Anpassung an wechselnde Umwelt (Nährstoff) bedingungen entschlüsselt durch quantitative Massenspektrometrie., in press


Research publications 

Zedelius J, Rabus R, Grundmann O, Werner I, Brodkorb D, Schreiber F,
Ehrenreich P, Behrends A, Wilkes H, Kube M, Reinhardt R, Friedrich Widdel F (2010)

Alkane degradation under anoxic conditions by a nitrate-reducing bacterium with possible involvement of the electron acceptor in substrate activation. Environ Microbiol Reports 3(1):125-135

Zink K, Rabus R (2010)
Stress-induced changes in phospholipids in Betaproteobacterium "Aromatoleum aromaticum" strain EbN1 due to alkylbenzene growth substrates. J Mol Microbiol Biotechnol 18:92-101

Amann J, Lange D, Schüler M, Rabus R (2010)
Substrate-dependent regulation of carbon catabolism in marine sulfate-reducing Desulfobacterium autotrophicum HRM2. J Mol Microbiol Biotechnol 18:74-84

Reviews or Book Chapters

Rabus R, Trautwein K (2010)
Proteogenomics to study the anaerobic degradation of aromatic compounds and hydrocarbons. In: KN Timmis (ed.), Handbook of Hydrocarbon and Lipid Metabolism. Springer-Verlag Berlin, DOI 10.1007/978-3-540-77587-4_344



Research publications 

Fürch T, Preusse P, Tomasch J, Zech H, Wagner-Döbler I, Rabus R, Wittmann C (2009) Metabolic
fluxes in the central carbon metabolism of Dinoroseobactershibae and Phaeobacter gallaeciensis,
two members of the marine Roseobacter clade.BMC Microbiology 9:209 doi:10.1186/1471-2180-9-209

Wagner-Döbler I, Baumgart M, Brinkhoff T, Buchholz I, Bunk B, Cypionka H, Daniel R, Drepper T, Gerdts G, Hahnke S, Han C, Jahn D, Kalhoefer D, Kiss H, Klenk HP, Kyrpides N, Liebl W, Liesegang H, Meincke L, Petersen J, Piekarski T, Pommerenke C, Pradella S, Pukall R, Rabus R, Stackebrandt E, Thole S, Thompson S, Tielen P, Tomasch J, von Jan M, Wanphrut N, Wichels A, Zech H, Simon M. (2009) The complete genome sequence of the algal symbiont Dinoroseobacter shibae – a hitchhiker`s guide to life in the sea. ISME J, accepted.

Zech H, Thole S, Schreiber K, Kalhöfer D, Voget S, Brinkhoff T, Simon M, Schomburg D, Rabus R (2009) Growth phase-dependent global protein and metabolite profiles of Phaeobacter gallaeciensis strain DSM 17395, a member of the marine Roseobacter-clade. Proteomics 9:3677-3697

Wöhlbrand L, Rabus R (2009) Development of a genetic system for the denitrifying bacterium 'Aromatoleum aromaticum' strain EbN1. J Mol Microbiol Biotechnol 17:41-52

Musat F, Galushko A, Jacob J, Widdel F, Kube M, Reinhardt R, Wilkes H, Schink B, Rabus R (2009) Anaerobic degradation of naphthalene and 2-methylnaphthalene by strains of marine sulfate-reducing bacteria. Environ Microbiol 11:209-219   

Strittmatter AW, Liesegang H, Rabus R, Decker I, Amann J, Andres S, Henne A, Fricke WF, Martinez-Arias R, Bartels D, Goesmann A, Krause L, Pühler A, Klenk H-P, Richter M, Schüler M, Glöckner FO, Meyerdierks A, Gottschalk G, Amann R (2009) Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate reducer oxidizing organic carbon completely to carbon dioxide. Environ Microbiol 11:1038-1055 

Tamang DG, Rabus R, Barabote RD, Saier MH Jr (2009) Comprehensive analyses of transport proteins encoded within the genome of "Aromatoleum aromaticum" strain EbN1. Journal of Membrane Biology 229:53-90


Research publications

Wöhlbrand L, Wilkes H, Halder T, Rabus R (2008) Anaerobic degradation of p-ethylphenol by „Aromatoleum aromaticum“ strain EbN1: pathway, involved proteins and regulation. J Bacteriol 190:5699-5709

Grundmann O, Behrends A, Rabus R, Amann J, Halder T, Heider J, Widdel F* (2008) Genes encoding the candidate enzyme for anaerobic activation of n-alkanes in the denitrifying bacterium, strain HxN1. Environ Microbiol 10:376–385

Trautwein K, Kühner S, Wöhlbrand L, Halder T, Kutcha K, Steinbüchel A, Rabus R (2008) Solvent stress response of the denitrifying strain EbN1. Appl Environ Microbiol 74:2267-2274


Research publications

Wöhlbrand L, Kallerhoff B, Lange D, Hufnagel P, Thiermann J, Reinhardt R, Rabus R (2007) Functional proteomic view of metabolic regulation in “Aromatoleum aromaticum” strain EbN1. Proteomics 7:2222-2239

Knaust F, Kube M*, Reinhardt R, Rabus R (2007) Anaylses of the vrl gene cluster in Desulfococcus multivorans: homologous to the virulence associated locus of the ovine footrot pathogen Dichelobacter nodosus strain A198. J Mol Microbiol Biotechnol 3:156-164

Reviews or book chapters

Rabus R, Strittmatter A (2007) Functional genomics of sulfate-reducing prokaryotes. In: Barton LL, Hamilton WA (eds) Sulphate-reducing bacteria. Environmental and engineered systems. pp. 117-140 Cambridge

Heider J, Rabus R (2007) Genomic insights in the anaerobic biodegradation of organic pollutants.In: Diaz E (ed) Microbial biodegradation: genomics and molecular biology. Horizon Scientific Press (in press).


Research publications

Hufnagel P, Rabus R (2006) Mass spectrometric identification in complex post-genomic projects. Soluble proteins of the metabolically versatile, denitrifying “Aromatoleum” sp. strain EbN1. J Mol Microbiol Biotechnol 11:53-81

Höffken HW*, Duong M, Friedrich T, Breuer M, Hauer B, Reinhardt R, Rabus R, Heider J (2006)
Crystal structure and enzyme kinetics of the (S)-specific 1-phenylethanol dehydrogenase of the
denitrifying bacterium strain EbN1. Biochemistry 45:82-93



Research publications

Rabus R, Kube M, Heider J, Beck A, Heitmann K, Widdel F, Reinhardt R (2005). The complete genome of an aromatic-degrading denitrifying bacterium, strain EbN1. Arch Microbiol 183:27-36

Kühner S, Wöhlbrandt L, Hufnagel P, Fritz I, Hultschig C, Kube M, Reinhardt R, Rabus R (2005) Substrate-dependent regulation of anaerobic ethylbenzene and toluene metabolism in a denitrifying bacterium, strain EbN1. J Bacteriol 187:1493-1503

Kube M, Beck A, Meyerdierks A, Amann R, Reinhardt R*, Rabus R (2005) A catabolic gene cluster for anaerobic benzoate degradation in methanotrophic microbial Black Sea mats. System Appl Microbiol 28:287-294

Mußmann M*, Ishii K, Rabus R, Amann R (2005) Diversity and distribution of cultured and uncultured Delta Proteobacteria in an intertidal mud flat of the Wadden Sea. Environ Microbiol 7:405-418

Gade D, Theiss D, Lange D, Mirgorodskaya E, Lombardot T, Kube M, Reinhardt R, Amann R, Lehrach H, Rabus R, Gobom J (2005) Towards the proteome of the marine bacterium Rhodopirellula baltica: mapping the soluble proteins. Proteomics 5:3654-3671

Gade D, Stührmann T, Gobom J, Rabus R (2005) Metabolic reconstruction and regulation in the marine bacterium Rhodopirellula baltica. Proteomics 5:3672-3683

Gade D, Stührmann T, Reinhardt R, Rabus R (2005) Proteomic analysis of growth stages and morphotypes in the marine bacterium Rhodopirellula baltica. Environ Microbiol 7:1074-1084

Reviews or book chapters

Rabus R (2005) Biodegradation of hydrocarbons under anoxic conditions. In: Ollivier B, Magot M (eds) Petroleum microbiology. pp. 277-299. ASM-Press Washington

Rabus R (2005) Functional genomics in an anaerobic aromatics-degrading denitrifying bacterium,
strain EbN1. Appl Microbiol Biotechnol 68:580-587



Research publications

Kube M, Heider J, Hufnagel P, Kühner S, Beck A, Reinhardt R, Rabus R (2004) Genes involved in the anaerobic degradation of toluene in a denitrifying bacterium, strain EbN1. Arch Microbiol 181:182-184

Rabus R, Ruepp A, Frickey T, Rattei T, Fartmann B, Stark M, Bauer M, Zibat A, Lombardot T, Becker I, Amann, J, Gellner K, Teeling H, Leuschner DW, Glöckner FO, Lupas AN, Amann R, Klenk HP* (2004) The genome of a sulphate-reducing bacterium from permanently cold Arctic sediment: Desulfotalea psychrophila. Environ Microbiol 6:887-902

Schlesner H*, Rathmann M, Bartels C, Tindall B, Gade D, Rabus R, Pfeiffer S, Hirsch P (2004) Taxonomic heterogeneity within the Planctomycetales as derived by DNA/DNA-hybridization, description of Rhodopirellula baltica gen. nov., sp. nov. and transfer of Pirellula marina to the genus Blastopirellula gen. nov. as Blastopirellula marina comb. nov. Int J Syst Evol Bacteriol 54:1567-1580

Hufnagel P, Schweiger-Hufnagel U, Behrens M, Macht M, Baessmann C, Suckau D, Schürenberg M, Rabus R (2004) Bakterium mit vorhergesagten ORFs – eine Herausforderung für die Proteomanalytik. Laborwelt 5 (4):31-34

Schweiger-Hufnagel U, Behrens M, Jürgens M, Baessmann C, Suckau D, Rabus R (2004) Neues
Werkzeug für die de-novo Sequenzierung von Proteinen. Biospektrum Sonderausgabe 10. Jahrgang:566-567


Research publications

Wilkes H*, Kühner S, Bolm C, Fischer Th, Classen A, Widdel F, Rabus R (2003) Formation of n-alkane and cycloalkane-derived organic acids during anaerobic growth of denitrifying bacteria with crude oil. Organ Geochem 34:1313-1323

Haveman SA, Brunelle V, Voordouw JK, Voordouw G*, Heidelberg JF, Rabus R (2003) Gene expression analysis of energy metabolism mutants of Desulfovibrio vulgaris Hildenborough indicates an important role for alcohol dehydrogenase. J Bacteriol 185:4345-4353

Gade D, Thiermann J, Markowsky D, Rabus R (2003) Evaluation of two-dimensional difference gel electrophoresis for protein profiling. Soluble proteins of the marine bacterium Pirellula sp. strain 1. J Mol Microbiol Biotechnol 5:240-251

Glöckner FO*, Kube M, Bauer M, Teeling H, Lombardot T, Ludwig W, Gade D, Beck A, Borzym K, Heitmann K, Rabus R, Schlesner H, Amann R, Reinhardt R (2003) Complete genome sequence of the marine planctomycete Pirellula sp. strain 1. Proc Natl Acad Sci 100:8298-8303

Reviews or book chapters

Widdel F*, Boetius A*, Rabus R (2003) Anaerobic biodegradation of hydrocarbons including methane.
In: Dworkin M, Falkow S, Rosenberg E, Schleifer K-H, Stackebrandt E (eds) The Prokaryotes 3rd
edition. Springer-Verlag Heidelberg



Research publications

Wilkes H*, Rabus R, Fischer T, Armstroff A, Behrends A, Widdel F (2002) Anaerobic degradation of n-hexane in a denitrifying bacterium: Further degradation of the initial intermediate (1-methylpentyl)succinate via C-skeleton rearrangement. Arch Microbiol 177:235-243

Llobet-Brossa E, Rabus R, Böttcher ME, Könneke M, Finke N, Schramm A, Meyer RL, Grötzschel S, Rosselló-Mora R, Amann R (2002) Community structure and activity of sulfate-reducing bacteria in an intertidal surface-sediment: a multi-methods approach. Aquatic Microbial Ecol 29:211-226

Rabus R, Kube M, Beck A, Widdel F, Reinhardt R (2002) Genes involved in the anaerobic degradation of ethylbenzene in a denitrifying bacterium, strain EbN1. Arch Microbiol 178:506-516

Rabus R, Brüchert V, Amann J, Könneke M (2002) Physiological response to temperature changes of the marine, sulfate-reducing bacterium Desulfobacterium autotrophicum. FEMS Microbiol Ecol 42:409-417

Rabus R, Gade D, Helbig R, Bauer M, Glöckner FO, Kube M, Schlesner H, Reinhardt R, Amann R (2002) Analysis of N-acetylglucosamine metabolism in the marine bacterium Pirellula sp. strain 1 by a proteomic approach. Proteomics 2:649-655

Reviews or book chapters

Widdel F*, Rabus R (2002) Anaerobic biodegradation of saturated and aromatic hydrocarbons. Curr
Opin Biotechnol 12:259-276



Research publications

Rabus R, Wilkes H, Behrends A, Armstroff A, Fischer Th, Pierik AJ, Widdel F (2001) Anaerobic initial reaction of n-alkanes in a denitrifying bacterium: Evidence for (1-methylpentyl)succinate as initial product and for involvement of an organic radical in n-hexane metabolism. J Bacteriol 183:1707-1715

Reviews or book chapters

Rabus R, Hansen T, Widdel F* (2001) Dissimilatory sulfate- and sulfur-reducing prokaryotes. In:
Dworkin M, Falkow S, Rosenberg E, Schleifer K-H, Stackebrandt E (eds) The Prokaryotes: an evolving
electronic resource for the microbiological community. Heidelberg, Springer Science Online



Research publications

Wilkes H*, Boreham C, Harms G, Zengler K, Rabus R (2000) Anaerobic degradation and carbon isotopic fractionation of alkylbenzenes in crude oil by sulphate-reducing bacteria. Organ Geochem 31:101-115

Paulsen IT*, Nguyen L, Sliwinski MK, Rabus R, Saier Jr MH (2000) Microbial genome analyses:
comparative transport capabilities in eighteen prokaryotes. J Mol Biol 301:75-100



Research publications

Champion KM, Zengler K, Rabus R (1999) Anaerobic degradation of ethylbenzene and toluene in denitrifying strain EbN1 proceeds via independent substrate-induced pathways. J Mol Microbiol Biotechnol 1:157-164

Harms G, Rabus R, Widdel F* (1999) Anaerobic oxidation of the aromatic plant hydrocarbon p-cymene by newly isolated denitrifying bacteria. Arch Microbiol 172:303-312

Harms G, Zengler K, Rabus R, Aeckersberg F, Minz D, Rosselló-Mora R, Widdel F* (1999) Anaerobic oxidation of o-xylene, m-xylene, and homologous alkylbenzenes by new types of sulfate-reducing bacteria. Appl Environ Microbiol 65:999-1004

Rabus R, Wilkes H, Schramm A, Harms G, Behrends A, Amann R, Widdel F (1999) Anaerobic utilization of alkylbenzenes and n-alkanes from crude oil in an enrichment culture of denitrifying bacteria affiliating with the b-subclass of Proteobacteria. Environ Microbiol 1:145-157

Rabus R, Jack DL, Kelly DJ, Saier Jr MH* (1999) TRAP transporters: an ancient family of extracytoplasmic solute-receptor-dependent secondary active transporters. Microbiology 145:3431-3445

Rabus R, Reizer J, Paulsen I, Saier Jr MH* (1999) Enzyme INtr from Escherichia coli. A novel enzyme of the phosphoenolpyruvate-dependent phosphotransferase system exhibiting strict specificity for its phosphoryl acceptor, NPr. J Biol Chem 274:26185-26191

Reviews or book chapters

Fukui M, Harms G, Rabus R, Schramm A, Wilkes H, Zengler K, Widdel F* (1999) Degradation of hydrocarbons from crude oil by anaerobic bacteria. In: Proceedings of the Seventh International Symposium on Microbial Ecology 1998, Halifax, USA. American Society for Microbiology, Washington DC

Rabus R (1999) Summer course on advanced bacterial genetics. Futura 14:82-84



Research publications

Rabus R, Heider J* (1998) Initial reactions of anaerobic metabolism of alkylbenzenes in denitrifying and sulfate-reducing bacteria. Arch Microbiol 170:377-384

Reizer J, Hoischen C, Titgemeyer F, Rivolta C, Rabus R, Stülke J, Karamata D, Saier Jr MH*, Hillen
W (1998) A novel protein kinase that controls carbon catabolite repression in bacteria.
Mol Microbiol 27:1157-1169



Reviews or book chapters

Aeckersberg F, Rueter P, Rabus R, Widdel F* (1997) Degradation of hydrocarbons by anaerobic bacteria.
In: Martins MT, Sato MIZ, Tiedje JM, Hagler LCN, Döbereiner J, Sanchez PS (eds) Progress in
microbial ecology, proceedings of the seventh international symposium on microbial ecology,
Brazilian Society for Microbiology, Sao Paulo, pp 69-75



Research publications

Rabus R, Widdel F (1996) Utilization of alkylbenzenes during anaerobic growth of pure cultures of denitrifying bacteria on crude oil. Appl Environ Microbiol 62:1238-1241

Rabus R, Fukui M, Wilkes H, Widdel F* (1996) Degradative capacities and 16S rRNA-targeted whole-cell
hybridization of sulfate-reducing bacteria in an anaerobic enrichment culture utilizing alkylbenzenes
from crude oil. Appl Environ Microbiol 62:3605-3613



Research publications

Rabus R, Widdel F* (1995) Anaerobic degradation of ethylbenzene and other aromatic hydrocarbons by new denitrifying bacteria. Arch Microbiol 163:96-103

Rabus R, Widdel F* (1995) Conversion studies with substrate analogues of toluene in a sulfate-reducing bacterium, strain Tol2. Arch Microbiol 164:448-451

Reviews or book chapters

Wilkes H*, Wilsch H, Rabus R, Aeckersberg F, Rueter P, Widdel F (1995) Compositional changes of
crude oils upon anaerobic degradation by sulphate-reducing bacteria. In: 17th International
Meeting on Organic Geochemistry, 1995. Donostia-San Sebastian, Spain



Research publications

Rueter P, Rabus R, Wilkes H, Aeckersberg F, Rainey FA, Jannasch HW, Widdel F* (1994)
Anaerobic oxidation of hydrocarbons in crude oil by new types of sulphate-reducing bacteria. Nature



Research publications

Rabus R, Nordhaus R, Ludwig W, Widdel F* (1993) Complete oxidation of toluene under strictly anoxic conditions by a new sulfate-reducing bacterium. Appl Environ Microbiol 59:1444-1451

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